BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 12362366)

  • 1. Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.
    Hendrix JA; Shimshock SJ; Shutske GM; Tomer JD; Kapples KJ; Palermo MG; Corbett TJ; Vargas HM; Kafka S; Brooks KM; Laws-Ricker L; Lee DK; de Lannoy I; Bordeleau M; Rizkalla G; Owolabi J; Kamboj RK
    Chembiochem; 2002 Oct; 3(10):999-1009. PubMed ID: 12362366
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
    Balle T; Perregaard J; Ramirez MT; Larsen AK; Søby KK; Liljefors T; Andersen K
    J Med Chem; 2003 Jan; 46(2):265-83. PubMed ID: 12519065
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
    Rowley M; Broughton HB; Collins I; Baker R; Emms F; Marwood R; Patel S; Patel S; Ragan CI; Freedman SB; Leeson PD
    J Med Chem; 1996 May; 39(10):1943-5. PubMed ID: 8642551
    [No Abstract]   [Full Text] [Related]  

  • 4. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.
    Carato P; Graulich A; Jensen N; Roth BL; Liégeois JF
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1570-4. PubMed ID: 17251022
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
    Carling RW; Moore KW; Moyes CR; Jones EA; Bonner K; Emms F; Marwood R; Patel S; Patel S; Fletcher AE; Beer M; Sohal B; Pike A; Leeson PD
    J Med Chem; 1999 Jul; 42(14):2706-15. PubMed ID: 10411491
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.
    Wang X; Bhatia PA; Daanen JF; Latsaw SP; Rohde J; Kolasa T; Hakeem AA; Matulenko MA; Nakane M; Uchic ME; Miller LN; Chang R; Moreland RB; Brioni JD; Stewart AO
    Bioorg Med Chem; 2005 Aug; 13(15):4667-78. PubMed ID: 15896964
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
    Campiani G; Butini S; Trotta F; Fattorusso C; Catalanotti B; Aiello F; Gemma S; Nacci V; Novellino E; Stark JA; Cagnotto A; Fumagalli E; Carnovali F; Cervo L; Mennini T
    J Med Chem; 2003 Aug; 46(18):3822-39. PubMed ID: 12930145
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor.
    Moreland RB; Terranova MA; Chang R; Uchic ME; Matulenko MA; Surber BW; Stewart AO; Brioni JD
    Eur J Pharmacol; 2004 Aug; 497(2):147-54. PubMed ID: 15306199
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
    Rowley M; Collins I; Broughton HB; Davey WB; Baker R; Emms F; Marwood R; Patel S; Patel S; Ragan CI; Freedman SB; Ball R; Leeson PD
    J Med Chem; 1997 Jul; 40(15):2374-85. PubMed ID: 9240352
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors.
    Depoortère R; Bardin L; Rodrigues M; Abrial E; Aliaga M; Newman-Tancredi A
    Behav Pharmacol; 2009 Jul; 20(4):303-11. PubMed ID: 19584712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
    Grundt P; Carlson EE; Cao J; Bennett CJ; McElveen E; Taylor M; Luedtke RR; Newman AH
    J Med Chem; 2005 Feb; 48(3):839-48. PubMed ID: 15689168
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
    Campiani G; Butini S; Fattorusso C; Catalanotti B; Gemma S; Nacci V; Morelli E; Cagnotto A; Mereghetti I; Mennini T; Carli M; Minetti P; Di Cesare MA; Mastroianni D; Scafetta N; Galletti B; Stasi MA; Castorina M; Pacifici L; Vertechy M; Di Serio S; Ghirardi O; Tinti O; Carminati P
    J Med Chem; 2004 Jan; 47(1):143-57. PubMed ID: 14695828
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist.
    Heinrich JN; Brennan J; Lai MH; Sullivan K; Hornby G; Popiolek M; Jiang LX; Pausch MH; Stack G; Marquis KL; Andree TH
    Eur J Pharmacol; 2006 Dec; 552(1-3):36-45. PubMed ID: 17056032
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
    Frølund B; Jensen LS; Guandalini L; Canillo C; Vestergaard HT; Kristiansen U; Nielsen B; Stensbøl TB; Madsen C; Krogsgaard-Larsen P; Liljefors T
    J Med Chem; 2005 Jan; 48(2):427-39. PubMed ID: 15658856
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.
    Hoefgen B; Decker M; Mohr P; Schramm AM; Rostom SA; El-Subbagh H; Schweikert PM; Rudolf DR; Kassack MU; Lehmann J
    J Med Chem; 2006 Jan; 49(2):760-9. PubMed ID: 16420061
    [TBL] [Abstract][Full Text] [Related]  

  • 16. S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: I. Cellular, electrophysiological, and neurochemical profile in comparison with ropinirole.
    Millan MJ; Cussac D; Gobert A; Lejeune F; Rivet JM; Mannoury La Cour C; Newman-Tancredi A; Peglion JL
    J Pharmacol Exp Ther; 2004 Jun; 309(3):903-20. PubMed ID: 14978194
    [TBL] [Abstract][Full Text] [Related]  

  • 17. KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia.
    Park WK; Jeong D; Cho H; Lee SJ; Cha MY; Pae AN; Choi KI; Koh HY; Kong JY
    Pharmacol Biochem Behav; 2005 Oct; 82(2):361-72. PubMed ID: 16216322
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands.
    Wu X; Chen J; Ji M; Varady J; Levant B; Wang S
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5813-6. PubMed ID: 15501046
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists.
    Egle I; Barriault N; Bordeleau M; Drage J; Dube L; Peragine J; Mazzocco L; Arora J; Jarvie K; Tehim A
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4847-50. PubMed ID: 15341937
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
    Carato P; Graulich A; Jensen N; Roth BL; Liégeois JF
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1565-9. PubMed ID: 17254782
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.