646 related articles for article (PubMed ID: 12374740)
1. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
Frödin M; Antal TL; Dümmler BA; Jensen CJ; Deak M; Gammeltoft S; Biondi RM
EMBO J; 2002 Oct; 21(20):5396-407. PubMed ID: 12374740
[TBL] [Abstract][Full Text] [Related]
2. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Collins BJ; Deak M; Murray-Tait V; Storey KG; Alessi DR
J Cell Sci; 2005 Nov; 118(Pt 21):5023-34. PubMed ID: 16219676
[TBL] [Abstract][Full Text] [Related]
3. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.
Biondi RM; Kieloch A; Currie RA; Deak M; Alessi DR
EMBO J; 2001 Aug; 20(16):4380-90. PubMed ID: 11500365
[TBL] [Abstract][Full Text] [Related]
4. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
Williams MR; Arthur JS; Balendran A; van der Kaay J; Poli V; Cohen P; Alessi DR
Curr Biol; 2000 Apr; 10(8):439-48. PubMed ID: 10801415
[TBL] [Abstract][Full Text] [Related]
5. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
Lizcano JM; Deak M; Morrice N; Kieloch A; Hastie CJ; Dong L; Schutkowski M; Reimer U; Alessi DR
J Biol Chem; 2002 Aug; 277(31):27839-49. PubMed ID: 12023960
[TBL] [Abstract][Full Text] [Related]
6. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Casamayor A; Torrance PD; Kobayashi T; Thorner J; Alessi DR
Curr Biol; 1999 Feb; 9(4):186-97. PubMed ID: 10074427
[TBL] [Abstract][Full Text] [Related]
7. A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
Frödin M; Jensen CJ; Merienne K; Gammeltoft S
EMBO J; 2000 Jun; 19(12):2924-34. PubMed ID: 10856237
[TBL] [Abstract][Full Text] [Related]
8. Phosphoinositide-dependent kinase-1 orthologues from five eukaryotes are activated by the hydrophobic motif in AGC kinases.
Silber J; Antal TL; Gammeltoft S; Rasmussen TE
Biochem Biophys Res Commun; 2004 Sep; 321(4):823-7. PubMed ID: 15358101
[TBL] [Abstract][Full Text] [Related]
9. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
García-Martínez JM; Alessi DR
Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
[TBL] [Abstract][Full Text] [Related]
10. Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.
Hauge C; Antal TL; Hirschberg D; Doehn U; Thorup K; Idrissova L; Hansen K; Jensen ON; Jørgensen TJ; Biondi RM; Frödin M
EMBO J; 2007 May; 26(9):2251-61. PubMed ID: 17446865
[TBL] [Abstract][Full Text] [Related]
11. Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Yang J; Cron P; Good VM; Thompson V; Hemmings BA; Barford D
Nat Struct Biol; 2002 Dec; 9(12):940-4. PubMed ID: 12434148
[TBL] [Abstract][Full Text] [Related]
12. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).
Keshwani MM; von Daake S; Newton AC; Harris TK; Taylor SS
J Biol Chem; 2011 Jul; 286(26):23552-8. PubMed ID: 21561857
[TBL] [Abstract][Full Text] [Related]
13. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Balendran A; Casamayor A; Deak M; Paterson A; Gaffney P; Currie R; Downes CP; Alessi DR
Curr Biol; 1999 Apr; 9(8):393-404. PubMed ID: 10226025
[TBL] [Abstract][Full Text] [Related]
14. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Scheid MP; Marignani PA; Woodgett JR
Mol Cell Biol; 2002 Sep; 22(17):6247-60. PubMed ID: 12167717
[TBL] [Abstract][Full Text] [Related]
15. A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.
Balendran A; Biondi RM; Cheung PC; Casamayor A; Deak M; Alessi DR
J Biol Chem; 2000 Jul; 275(27):20806-13. PubMed ID: 10764742
[TBL] [Abstract][Full Text] [Related]
16. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
Collins BJ; Deak M; Arthur JS; Armit LJ; Alessi DR
EMBO J; 2003 Aug; 22(16):4202-11. PubMed ID: 12912918
[TBL] [Abstract][Full Text] [Related]
17. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Kobayashi T; Cohen P
Biochem J; 1999 Apr; 339 ( Pt 2)(Pt 2):319-28. PubMed ID: 10191262
[TBL] [Abstract][Full Text] [Related]
18. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.
Biondi RM; Komander D; Thomas CC; Lizcano JM; Deak M; Alessi DR; van Aalten DM
EMBO J; 2002 Aug; 21(16):4219-28. PubMed ID: 12169624
[TBL] [Abstract][Full Text] [Related]
19. Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
Auld GC; Campbell DG; Morrice N; Cohen P
Biochem J; 2005 Aug; 389(Pt 3):775-83. PubMed ID: 15910284
[TBL] [Abstract][Full Text] [Related]
20. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Dong LQ; Liu F
Am J Physiol Endocrinol Metab; 2005 Aug; 289(2):E187-96. PubMed ID: 16014356
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
