BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 12384496)

  • 21. Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.
    McConnachie LA; Mohar I; Hudson FN; Ware CB; Ladiges WC; Fernandez C; Chatterton-Kirchmeier S; White CC; Pierce RH; Kavanagh TJ
    Toxicol Sci; 2007 Oct; 99(2):628-36. PubMed ID: 17584759
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.
    Krzywanski DM; Dickinson DA; Iles KE; Wigley AF; Franklin CC; Liu RM; Kavanagh TJ; Forman HJ
    Arch Biochem Biophys; 2004 Mar; 423(1):116-25. PubMed ID: 14871475
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.
    Inoue Y; Tomisawa M; Yamazaki H; Abe Y; Suemizu H; Tsukamoto H; Tomii Y; Kawamura M; Kijima H; Hatanaka H; Ueyama Y; Nakamura M; Kobayashi K
    Int J Oncol; 2003 Nov; 23(5):1333-9. PubMed ID: 14532974
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.
    Chen Y; Johansson E; Fan Y; Shertzer HG; Vasiliou V; Nebert DW; Dalton TP
    Free Radic Biol Med; 2009 Aug; 47(4):410-8. PubMed ID: 19427898
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits.
    Willis MN; Liu Y; Biterova EI; Simpson MA; Kim H; Lee J; Barycki JJ
    Biochemistry; 2011 Jul; 50(29):6508-17. PubMed ID: 21657237
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.
    Liang LP; Kavanagh TJ; Patel M
    Toxicol Sci; 2013 Aug; 134(2):366-73. PubMed ID: 23704229
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Glutathione defense mechanism in liver injury: insights from animal models.
    Chen Y; Dong H; Thompson DC; Shertzer HG; Nebert DW; Vasiliou V
    Food Chem Toxicol; 2013 Oct; 60():38-44. PubMed ID: 23856494
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo.
    Föller M; Harris IS; Elia A; John R; Lang F; Kavanagh TJ; Mak TW
    Cell Death Differ; 2013 Oct; 20(10):1350-8. PubMed ID: 23787995
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.
    Yamaguchi H; Kidachi Y; Kamiie K; Noshita T; Umetsu H; Fuke Y; Ryoyama K
    Biochem Pharmacol; 2013 Aug; 86(4):458-68. PubMed ID: 23791871
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.
    Kann S; Estes C; Reichard JF; Huang MY; Sartor MA; Schwemberger S; Chen Y; Dalton TP; Shertzer HG; Xia Y; Puga A
    Toxicol Sci; 2005 Oct; 87(2):365-84. PubMed ID: 16014739
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice.
    Weldy CS; Luttrell IP; White CC; Morgan-Stevenson V; Bammler TK; Beyer RP; Afsharinejad Z; Kim F; Chitaley K; Kavanagh TJ
    Free Radic Biol Med; 2012 Sep; 53(6):1264-78. PubMed ID: 22824862
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs.
    Dasgupta A; Das S; Sarkar PK
    Free Radic Biol Med; 2007 Mar; 42(5):617-26. PubMed ID: 17291985
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Expression of glutamate-cysteine ligase during mouse development.
    Díaz D; Krejsa CM; Kavanagh TJ
    Mol Reprod Dev; 2002 May; 62(1):83-91. PubMed ID: 11933164
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits.
    Sikalidis AK; Mazor KM; Lee JI; Roman HB; Hirschberger LL; Stipanuk MH
    Amino Acids; 2014 May; 46(5):1285-96. PubMed ID: 24557597
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice.
    Chen Y; Curran CP; Nebert DW; Patel KV; Williams MT; Vorhees CV
    Neurotoxicol Teratol; 2012 Jul; 34(4):450-7. PubMed ID: 22580179
    [TBL] [Abstract][Full Text] [Related]  

  • 36. In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective.
    Ortiz L; Nakamura B; Li X; Blumberg B; Luderer U
    Toxicol Lett; 2013 Nov; 223(2):260-7. PubMed ID: 24107266
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.
    Nakamura BN; Fielder TJ; Hoang YD; Lim J; McConnachie LA; Kavanagh TJ; Luderer U
    Endocrinology; 2011 Jul; 152(7):2806-15. PubMed ID: 21558310
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.
    Sánchez-Vallejo V; Benlloch-Navarro S; Trachsel-Moncho L; López-Pedrajas R; Almansa I; Romero FJ; Miranda M
    Free Radic Biol Med; 2016 Jul; 96():245-54. PubMed ID: 27140233
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.
    Fraser JA; Kansagra P; Kotecki C; Saunders RD; McLellan LI
    J Biol Chem; 2003 Nov; 278(47):46369-77. PubMed ID: 12954617
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific.
    Tsai-Turton M; Luderer U
    Am J Physiol Endocrinol Metab; 2005 Sep; 289(3):E391-402. PubMed ID: 15811874
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 17.