BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 12386125)

  • 1. Effects of G169R and P34S substitutions produced by mutations of CYP2D6*14 on the functional properties of CYP2D6 expressed in V79 cells.
    Shiraishi T; Hosokawa M; Kobayashi K; Tainaka H; Yamaura Y; Taguchi M; Chiba K
    Drug Metab Dispos; 2002 Nov; 30(11):1201-5. PubMed ID: 12386125
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional evaluation of cytochrome P450 2D6 with Gly42Arg substitution expressed in Saccharomyces cerevisiae.
    Tsuzuki D; Takemi C; Yamamoto S; Tamagake K; Imaoka S; Funae Y; Kataoka H; Shinoda S; Narimatsu S
    Pharmacogenetics; 2001 Nov; 11(8):709-18. PubMed ID: 11692080
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B.
    Dong AN; Ahemad N; Pan Y; Palanisamy UD; Yiap BC; Ong CE
    Drug Metab Bioanal Lett; 2022; 15(1):51-63. PubMed ID: 35049443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese.
    Wang SL; Lai MD; Huang JD
    Drug Metab Dispos; 1999 Mar; 27(3):385-8. PubMed ID: 10064570
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C.
    Kim J; Lim YR; Han S; Han JS; Chun YJ; Yun CH; Lee CH; Kim D
    Arch Pharm Res; 2013 Dec; 36(12):1500-6. PubMed ID: 23897164
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.
    Oscarson M; Hidestrand M; Johansson I; Ingelman-Sundberg M
    Mol Pharmacol; 1997 Dec; 52(6):1034-40. PubMed ID: 9415713
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.
    Uehara S; Uno Y; Hagihira Y; Murayama N; Shimizu M; Inoue T; Sasaki E; Yamazaki H
    Xenobiotica; 2015; 45(9):766-72. PubMed ID: 25801057
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.
    Zhuge J; Yu YN; Wu XD
    World J Gastroenterol; 2004 Jan; 10(2):234-7. PubMed ID: 14716830
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comparison of cytochrome P450 2D6 and variants in terms of drug oxidation rates and substrate inhibition.
    Niwa T; Murayama N; Yamazaki H
    Curr Drug Metab; 2011 Jun; 12(5):412-35. PubMed ID: 21453270
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression, purification, and characterization of mouse CYP2d22.
    Yu AM; Haining RL
    Drug Metab Dispos; 2006 Jul; 34(7):1167-74. PubMed ID: 16595712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.
    Allorge D; Bréant D; Harlow J; Chowdry J; Lo-Guidice JM; Chevalier D; Cauffiez C; Lhermitte M; Blaney FE; Tucker GT; Broly F; Ellis SW
    Proteins; 2005 May; 59(2):339-46. PubMed ID: 15726636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.
    Uno Y; Uehara S; Kohara S; Murayama N; Yamazaki H
    Drug Metab Dispos; 2010 Sep; 38(9):1486-92. PubMed ID: 20501912
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.
    Niwa T; Hiroi T; Tsuzuki D; Yamamoto S; Narimatsu S; Fukuda T; Azuma J; Funae Y
    Brain Res Mol Brain Res; 2004 Oct; 129(1-2):117-23. PubMed ID: 15469888
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
    Deeni YY; Paine MJ; Ayrton AD; Clarke SE; Chenery R; Wolf CR
    Arch Biochem Biophys; 2001 Dec; 396(1):16-24. PubMed ID: 11716457
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
    Shen H; He MM; Liu H; Wrighton SA; Wang L; Guo B; Li C
    Drug Metab Dispos; 2007 Aug; 35(8):1292-300. PubMed ID: 17470523
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.
    Fukuda T; Nishida Y; Imaoka S; Hiroi T; Naohara M; Funae Y; Azuma J
    Arch Biochem Biophys; 2000 Aug; 380(2):303-8. PubMed ID: 10933885
    [TBL] [Abstract][Full Text] [Related]  

  • 17. V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.
    Krebsfaenger N; Mürdter TE; Zanger UM; Eichelbaum MF; Doehmer J
    ALTEX; 2003; 20(3):143-54. PubMed ID: 12947487
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
    Johansson I; Oscarson M; Yue QY; Bertilsson L; Sjöqvist F; Ingelman-Sundberg M
    Mol Pharmacol; 1994 Sep; 46(3):452-9. PubMed ID: 7935325
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.
    Geier M; Braun A; Fladischer P; Stepniak P; Rudroff F; Hametner C; Mihovilovic MD; Glieder A
    FEBS J; 2013 Jul; 280(13):3094-108. PubMed ID: 23552177
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.
    Bonifacio A; Keizers PH; Commandeur JN; Vermeulen NP; Robert B; Gooijer C; van der Zwan G
    Biochem Biophys Res Commun; 2006 May; 343(3):772-9. PubMed ID: 16563352
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.