These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
24. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Hook V; Toneff T; Bogyo M; Greenbaum D; Medzihradszky KF; Neveu J; Lane W; Hook G; Reisine T Biol Chem; 2005 Sep; 386(9):931-40. PubMed ID: 16164418 [TBL] [Abstract][Full Text] [Related]
25. Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Silvestri R Med Res Rev; 2009 Mar; 29(2):295-338. PubMed ID: 18651582 [TBL] [Abstract][Full Text] [Related]
26. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein. Na CH; Jeon SH; Zhang G; Olson GL; Chae CB J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811 [TBL] [Abstract][Full Text] [Related]
27. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373 [TBL] [Abstract][Full Text] [Related]
29. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Yu WH; Kumar A; Peterhoff C; Shapiro Kulnane L; Uchiyama Y; Lamb BT; Cuervo AM; Nixon RA Int J Biochem Cell Biol; 2004 Dec; 36(12):2531-40. PubMed ID: 15325590 [TBL] [Abstract][Full Text] [Related]
30. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. Hook VY; Reisine TD J Neurosci Res; 2003 Nov; 74(3):393-405. PubMed ID: 14598316 [TBL] [Abstract][Full Text] [Related]
31. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Holsinger RM; McLean CA; Beyreuther K; Masters CL; Evin G Ann Neurol; 2002 Jun; 51(6):783-6. PubMed ID: 12112088 [TBL] [Abstract][Full Text] [Related]
32. Secretase inhibitors and modulators for Alzheimer's disease treatment. Tomita T Expert Rev Neurother; 2009 May; 9(5):661-79. PubMed ID: 19402777 [TBL] [Abstract][Full Text] [Related]
33. RNA interference in silencing of genes of Alzheimer's disease in cellular and rat brain models. Sierant M; Kubiak K; Kazmierczak-Baranska J; Paduszynska A; Kuwabara T; Warashina M; Nacmias B; Sorbi S; Nawrot B Nucleic Acids Symp Ser (Oxf); 2008; (52):41-2. PubMed ID: 18776243 [TBL] [Abstract][Full Text] [Related]
34. Design and development of BACE-1 inhibitors. Cumming JN; Iserloh U; Kennedy ME Curr Opin Drug Discov Devel; 2004 Jul; 7(4):536-56. PubMed ID: 15338962 [TBL] [Abstract][Full Text] [Related]
35. Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain. Stockley JH; Ravid R; O'Neill C FEBS Lett; 2006 Dec; 580(28-29):6550-60. PubMed ID: 17113083 [TBL] [Abstract][Full Text] [Related]
36. Alzheimer's disease. A firm base for drug development. De Strooper B; König G Nature; 1999 Dec; 402(6761):471-2. PubMed ID: 10591201 [No Abstract] [Full Text] [Related]
37. Recent advances in the development of gamma-secretase inhibitors. Josien H Curr Opin Drug Discov Devel; 2002 Jul; 5(4):513-25. PubMed ID: 12197309 [TBL] [Abstract][Full Text] [Related]
38. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets. Evin G; Zhu A; Holsinger RM; Masters CL; Li QX J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315 [TBL] [Abstract][Full Text] [Related]
39. Prediction of the tertiary structure of the beta-secretase zymogen. Chou KC; Howe WJ Biochem Biophys Res Commun; 2002 Apr; 292(3):702-8. PubMed ID: 11922623 [TBL] [Abstract][Full Text] [Related]
40. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Malamas MS; Barnes K; Hui Y; Johnson M; Lovering F; Condon J; Fobare W; Solvibile W; Turner J; Hu Y; Manas ES; Fan K; Olland A; Chopra R; Bard J; Pangalos MN; Reinhart P; Robichaud AJ Bioorg Med Chem Lett; 2010 Apr; 20(7):2068-73. PubMed ID: 20223661 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]