114 related articles for article (PubMed ID: 12392745)
1. Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.
Ruchelman AL; Singh SK; Wu X; Ray A; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem Lett; 2002 Nov; 12(22):3333-6. PubMed ID: 12392745
[TBL] [Abstract][Full Text] [Related]
2. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
Ruchelman AL; Singh SK; Ray A; Wu XH; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2003 May; 11(9):2061-73. PubMed ID: 12670657
[TBL] [Abstract][Full Text] [Related]
3. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
[TBL] [Abstract][Full Text] [Related]
4. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
[TBL] [Abstract][Full Text] [Related]
5. Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Vicker N; Burgess L; Chuckowree IS; Dodd R; Folkes AJ; Hardick DJ; Hancox TC; Miller W; Milton J; Sohal S; Wang S; Wren SP; Charlton PA; Dangerfield W; Liddle C; Mistry P; Stewart AJ; Denny WA
J Med Chem; 2002 Jan; 45(3):721-39. PubMed ID: 11806724
[TBL] [Abstract][Full Text] [Related]
6. Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.
Yu Y; Singh SK; Liu A; Li TK; Liu LF; LaVoie EJ
Bioorg Med Chem; 2003 Apr; 11(7):1475-91. PubMed ID: 12628673
[TBL] [Abstract][Full Text] [Related]
7. Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Gamage SA; Spicer JA; Finlay GJ; Stewart AJ; Charlton P; Baguley BC; Denny WA
J Med Chem; 2001 Apr; 44(9):1407-15. PubMed ID: 11311063
[TBL] [Abstract][Full Text] [Related]
8. The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine.
Marshall KM; Matsumoto SS; Holden JA; Concepción GP; Tasdemir D; Ireland CM; Barrows LR
Biochem Pharmacol; 2003 Aug; 66(3):447-58. PubMed ID: 12907244
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues.
Sugimori M; Ejima A; Ohsuki S; Uoto K; Mitsui I; Kawato Y; Hirota Y; Sato K; Terasawa H
J Med Chem; 1998 Jun; 41(13):2308-18. PubMed ID: 9632364
[TBL] [Abstract][Full Text] [Related]
10. Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Uehling DE; Nanthakumar SS; Croom D; Emerson DL; Leitner PP; Luzzio MJ; McIntyre G; Morton B; Profeta S; Sisco J
J Med Chem; 1995 Mar; 38(7):1106-18. PubMed ID: 7707314
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives.
Ferlin MG; Marzano C; Chiarelotto G; Baccichetti F; Bordin F
Eur J Med Chem; 2000 Sep; 35(9):827-37. PubMed ID: 11006484
[TBL] [Abstract][Full Text] [Related]
12. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents.
Li D; Zhao B; Sim SP; Li TK; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2003 Feb; 11(4):521-8. PubMed ID: 12538017
[TBL] [Abstract][Full Text] [Related]
13. 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Klutchko SR; Hamby JM; Boschelli DH; Wu Z; Kraker AJ; Amar AM; Hartl BG; Shen C; Klohs WD; Steinkampf RW; Driscoll DL; Nelson JM; Elliott WL; Roberts BJ; Stoner CL; Vincent PW; Dykes DJ; Panek RL; Lu GH; Major TC; Dahring TK; Hallak H; Bradford LA; Showalter HD; Doherty AM
J Med Chem; 1998 Aug; 41(17):3276-92. PubMed ID: 9703473
[TBL] [Abstract][Full Text] [Related]
14. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Ruchelman AL; Houghton PJ; Zhou N; Liu A; Liu LF; LaVoie EJ
J Med Chem; 2005 Feb; 48(3):792-804. PubMed ID: 15689163
[TBL] [Abstract][Full Text] [Related]
15. Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.
Chaniyara R; Tala S; Chen CW; Zang X; Kakadiya R; Lin LF; Chen CH; Chien SI; Chou TC; Tsai TH; Lee TC; Shah A; Su TL
J Med Chem; 2013 Feb; 56(4):1544-63. PubMed ID: 23360284
[TBL] [Abstract][Full Text] [Related]
16. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Li TK; Houghton PJ; Desai SD; Daroui P; Liu AA; Hars ES; Ruchelman AL; LaVoie EJ; Liu LF
Cancer Res; 2003 Dec; 63(23):8400-7. PubMed ID: 14679002
[TBL] [Abstract][Full Text] [Related]
17. Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs.
Spicer JA; Gamage SA; Rewcastle GW; Finlay GJ; Bridewell DJ; Baguley BC; Denny WA
J Med Chem; 2000 Apr; 43(7):1350-8. PubMed ID: 10753472
[TBL] [Abstract][Full Text] [Related]
18. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents.
Chen W; Shen Y; Li Z; Zhang M; Lu C; Shen Y
Eur J Med Chem; 2014 Oct; 86():782-96. PubMed ID: 25240702
[TBL] [Abstract][Full Text] [Related]
19. New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents.
Zhu HY; Desai J; Cooper AB; Wang J; Rane DF; Kirschmeier P; Strickland C; Liu M; Nomeir AA; Girijavallabhan VM
Bioorg Med Chem Lett; 2014 Feb; 24(4):1228-31. PubMed ID: 24462667
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Kim DK; Ryu DH; Lee JY; Lee N; Kim YW; Kim JS; Chang K; Im GJ; Kim TK; Choi WS
J Med Chem; 2001 May; 44(10):1594-602. PubMed ID: 11334569
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]