These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 12392761)

  • 1. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
    Tortorella MD; Liu RQ; Burn T; Newton RC; Arner E
    Matrix Biol; 2002 Oct; 21(6):499-511. PubMed ID: 12392761
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
    Tortorella MD; Malfait AM; Deccico C; Arner E
    Osteoarthritis Cartilage; 2001 Aug; 9(6):539-52. PubMed ID: 11520168
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
    Malfait AM; Liu RQ; Ijiri K; Komiya S; Tortorella MD
    J Biol Chem; 2002 Jun; 277(25):22201-8. PubMed ID: 11956193
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.
    Makihira S; Yan W; Murakami H; Furukawa M; Kawai T; Nikawa H; Yoshida E; Hamada T; Okada Y; Kato Y
    Endocrinology; 2003 Jun; 144(6):2480-8. PubMed ID: 12746310
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Variations in aggrecan structure modulate its susceptibility to aggrecanases.
    Roughley PJ; Barnett J; Zuo F; Mort JS
    Biochem J; 2003 Oct; 375(Pt 1):183-9. PubMed ID: 12859252
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
    Tortorella MD; Pratta M; Liu RQ; Austin J; Ross OH; Abbaszade I; Burn T; Arner E
    J Biol Chem; 2000 Jun; 275(24):18566-73. PubMed ID: 10751421
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C; Büttner FH; Kern C; Schmiedeknecht G; Bartnik E
    Matrix Biol; 2000 Nov; 19(6):533-43. PubMed ID: 11068207
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
    Bau B; Gebhard PM; Haag J; Knorr T; Bartnik E; Aigner T
    Arthritis Rheum; 2002 Oct; 46(10):2648-57. PubMed ID: 12384923
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein.
    Pratta MA; Scherle PA; Yang G; Liu RQ; Newton RC
    Arthritis Rheum; 2003 Jan; 48(1):119-33. PubMed ID: 12528112
    [TBL] [Abstract][Full Text] [Related]  

  • 10. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
    Kashiwagi M; Tortorella M; Nagase H; Brew K
    J Biol Chem; 2001 Apr; 276(16):12501-4. PubMed ID: 11278243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
    Tortorella M; Pratta M; Liu RQ; Abbaszade I; Ross H; Burn T; Arner E
    J Biol Chem; 2000 Aug; 275(33):25791-7. PubMed ID: 10827174
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
    Kashiwagi M; Enghild JJ; Gendron C; Hughes C; Caterson B; Itoh Y; Nagase H
    J Biol Chem; 2004 Mar; 279(11):10109-19. PubMed ID: 14662755
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.
    Little CB; Hughes CE; Curtis CL; Jones SA; Caterson B; Flannery CR
    Arthritis Rheum; 2002 Jan; 46(1):124-9. PubMed ID: 11817583
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
    De Savi C; Pape A; Sawyer Y; Milne D; Davies C; Cumming JG; Ting A; Lamont S; Smith PD; Tart J; Page K; Moore P
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3301-6. PubMed ID: 21536437
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An aggrecanase and osteoarthritis.
    Karsenty G
    N Engl J Med; 2005 Aug; 353(5):522-3. PubMed ID: 16079379
    [No Abstract]   [Full Text] [Related]  

  • 16. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD; Pratta MA; Fox JW; Arner EC
    J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Role of aggrecanase and MMP in cartilage degradation].
    Ishiguro N; Kojima T
    Clin Calcium; 2004 Jul; 14(7):38-44. PubMed ID: 15577074
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The cleavage of biglycan by aggrecanases.
    Melching LI; Fisher WD; Lee ER; Mort JS; Roughley PJ
    Osteoarthritis Cartilage; 2006 Nov; 14(11):1147-54. PubMed ID: 16806997
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
    Stanton H; Rogerson FM; East CJ; Golub SB; Lawlor KE; Meeker CT; Little CB; Last K; Farmer PJ; Campbell IK; Fourie AM; Fosang AJ
    Nature; 2005 Mar; 434(7033):648-52. PubMed ID: 15800625
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
    Tortorella MD; Burn TC; Pratta MA; Abbaszade I; Hollis JM; Liu R; Rosenfeld SA; Copeland RA; Decicco CP; Wynn R; Rockwell A; Yang F; Duke JL; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis DM; Ross H; Wiswall BH; Murphy K; Hillman MC; Hollis GF; Newton RC; Magolda RL; Trzaskos JM; Arner EC
    Science; 1999 Jun; 284(5420):1664-6. PubMed ID: 10356395
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.