410 related articles for article (PubMed ID: 12395425)
1. pKa, MM, and QM studies of mechanisms of beta-lactamases and penicillin-binding proteins: acylation step.
Massova I; Kollman PA
J Comput Chem; 2002 Dec; 23(16):1559-76. PubMed ID: 12395425
[TBL] [Abstract][Full Text] [Related]
2. Understanding the acylation mechanisms of active-site serine penicillin-recognizing proteins: a molecular dynamics simulation study.
Oliva M; Dideberg O; Field MJ
Proteins; 2003 Oct; 53(1):88-100. PubMed ID: 12945052
[TBL] [Abstract][Full Text] [Related]
3. Mixed quantum mechanical/molecular mechanical (QM/MM) study of the deacylation reaction in a penicillin binding protein (PBP) versus in a class C beta-lactamase.
Gherman BF; Goldberg SD; Cornish VW; Friesner RA
J Am Chem Soc; 2004 Jun; 126(24):7652-64. PubMed ID: 15198613
[TBL] [Abstract][Full Text] [Related]
4. The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.
Golemi-Kotra D; Meroueh SO; Kim C; Vakulenko SB; Bulychev A; Stemmler AJ; Stemmler TL; Mobashery S
J Biol Chem; 2004 Aug; 279(33):34665-73. PubMed ID: 15152012
[TBL] [Abstract][Full Text] [Related]
5. Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.
Meroueh SO; Minasov G; Lee W; Shoichet BK; Mobashery S
J Am Chem Soc; 2003 Aug; 125(32):9612-8. PubMed ID: 12904027
[TBL] [Abstract][Full Text] [Related]
6. Mechanisms of antibiotic resistance: QM/MM modeling of the acylation reaction of a class A beta-lactamase with benzylpenicillin.
Hermann JC; Hensen C; Ridder L; Mulholland AJ; Höltje HD
J Am Chem Soc; 2005 Mar; 127(12):4454-65. PubMed ID: 15783228
[TBL] [Abstract][Full Text] [Related]
7. Beta-secondary and solvent deuterium kinetic isotope effects on beta-lactamase catalysis.
Adediran SA; Deraniyagala SA; Xu Y; Pratt RF
Biochemistry; 1996 Mar; 35(11):3604-13. PubMed ID: 8639512
[TBL] [Abstract][Full Text] [Related]
8. Penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus: kinetic characterization of its interactions with beta-lactams using electrospray mass spectrometry.
Lu WP; Sun Y; Bauer MD; Paule S; Koenigs PM; Kraft WG
Biochemistry; 1999 May; 38(20):6537-46. PubMed ID: 10350472
[TBL] [Abstract][Full Text] [Related]
9. Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.
Strynadka NC; Adachi H; Jensen SE; Johns K; Sielecki A; Betzel C; Sutoh K; James MN
Nature; 1992 Oct; 359(6397):700-5. PubMed ID: 1436034
[TBL] [Abstract][Full Text] [Related]
10. Conformational analysis of bacterial cell wall peptides indicates how particular conformations have influenced the evolution of penicillin-binding proteins, beta-lactam antibiotics and antibiotic resistance mechanisms.
Grail BM; Payne JW
J Mol Recognit; 2002; 15(3):113-25. PubMed ID: 12203837
[TBL] [Abstract][Full Text] [Related]
11. Identification of Glu166 as the general base in the acylation reaction of class A beta-lactamases through QM/MM modeling.
Hermann JC; Ridder L; Mulholland AJ; Höltje HD
J Am Chem Soc; 2003 Aug; 125(32):9590-1. PubMed ID: 12904016
[TBL] [Abstract][Full Text] [Related]
12. Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities.
Stefanova ME; Tomberg J; Olesky M; Höltje JV; Gutheil WG; Nicholas RA
Biochemistry; 2003 Dec; 42(49):14614-25. PubMed ID: 14661974
[TBL] [Abstract][Full Text] [Related]
13. Selection of beta-lactamases and penicillin binding mutants from a library of phage displayed TEM-1 beta-lactamase randomly mutated in the active site omega-loop.
Vanwetswinkel S; Avalle B; Fastrez J
J Mol Biol; 2000 Jan; 295(3):527-40. PubMed ID: 10623544
[TBL] [Abstract][Full Text] [Related]
14. Beta-secondary and solvent deuterium kinetic isotope effects on catalysis by the Streptomyces R61 DD-peptidase: comparisons with a structurally similar class C beta-lactamase.
Adediran SA; Pratt RF
Biochemistry; 1999 Feb; 38(5):1469-77. PubMed ID: 9931012
[TBL] [Abstract][Full Text] [Related]
15. Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.
Meroueh SO; Fisher JF; Schlegel HB; Mobashery S
J Am Chem Soc; 2005 Nov; 127(44):15397-407. PubMed ID: 16262403
[TBL] [Abstract][Full Text] [Related]
16. High level QM/MM modeling of the formation of the tetrahedral intermediate in the acylation of wild type and K73A mutant TEM-1 class A beta-lactamase.
Hermann JC; Pradon J; Harvey JN; Mulholland AJ
J Phys Chem A; 2009 Oct; 113(43):11984-94. PubMed ID: 19791786
[TBL] [Abstract][Full Text] [Related]
17. Identification of the active site serine of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by electrospray mass spectrometry.
Sun Y; Bauer MD; Lu W
J Mass Spectrom; 1998 Oct; 33(10):1009-16. PubMed ID: 9821332
[TBL] [Abstract][Full Text] [Related]
18. Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution.
Davies C; White SW; Nicholas RA
J Biol Chem; 2001 Jan; 276(1):616-23. PubMed ID: 10967102
[TBL] [Abstract][Full Text] [Related]
19. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Lim D; Strynadka NC
Nat Struct Biol; 2002 Nov; 9(11):870-6. PubMed ID: 12389036
[TBL] [Abstract][Full Text] [Related]
20. Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Rhazi N; Charlier P; Dehareng D; Engher D; Vermeire M; Frère JM; Nguyen-Distèche M; Fonzé E
Biochemistry; 2003 Mar; 42(10):2895-906. PubMed ID: 12627955
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
