BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

116 related articles for article (PubMed ID: 12406504)

  • 1. Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.
    Ray AS; Murakami E; Peterson CN; Shi J; Schinazi RF; Anderson KS
    Antiviral Res; 2002 Dec; 56(3):189-205. PubMed ID: 12406504
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.
    Hammond JL; Parikh UM; Koontz DL; Schlueter-Wirtz S; Chu CK; Bazmi HZ; Schinazi RF; Mellors JW
    Antimicrob Agents Chemother; 2005 Sep; 49(9):3930-2. PubMed ID: 16127074
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.
    Murakami E; Ray AS; Schinazi RF; Anderson KS
    Antiviral Res; 2004 Apr; 62(1):57-64. PubMed ID: 15026203
    [TBL] [Abstract][Full Text] [Related]  

  • 4. HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
    Geleziunas R; Gallagher K; Zhang H; Bacheler L; Garber S; Wu JT; Shi G; Otto MJ; Schinazi RF; Erickson-Viitanen S
    Antivir Chem Chemother; 2003 Jan; 14(1):49-59. PubMed ID: 12790516
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
    Shi J; McAtee JJ; Schlueter Wirtz S; Tharnish P; Juodawlkis A; Liotta DC; Schinazi RF
    J Med Chem; 1999 Mar; 42(5):859-67. PubMed ID: 10072683
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase.
    Anderson KS
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):296-9. PubMed ID: 12084471
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.
    Faraj A; Agrofoglio LA; Wakefield JK; McPherson S; Morrow CD; Gosselin G; Mathe C; Imbach JL; Schinazi RF; Sommadossi JP
    Antimicrob Agents Chemother; 1994 Oct; 38(10):2300-5. PubMed ID: 7530932
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.
    Ray AS; Schinazi RF; Murakami E; Basavapathruni A; Shi J; Zorca SM; Chu CK; Anderson KS
    Antivir Chem Chemother; 2003 May; 14(3):115-25. PubMed ID: 14521328
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
    Feng JY; Murakami E; Zorca SM; Johnson AA; Johnson KA; Schinazi RF; Furman PA; Anderson KS
    Antimicrob Agents Chemother; 2004 Apr; 48(4):1300-6. PubMed ID: 15047533
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Elucidating molecular interactions of
    Hung M; Tokarsky EJ; Lagpacan L; Zhang L; Suo Z; Lansdon EB
    Commun Biol; 2019; 2():469. PubMed ID: 31872074
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.
    Klarmann GJ; Smith RA; Schinazi RF; North TW; Preston BD
    J Biol Chem; 2000 Jan; 275(1):359-66. PubMed ID: 10617626
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
    Feng JY; Shi J; Schinazi RF; Anderson KS
    FASEB J; 1999 Sep; 13(12):1511-7. PubMed ID: 10463941
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
    Gao HQ; Boyer PL; Sarafianos SG; Arnold E; Hughes SH
    J Mol Biol; 2000 Jul; 300(2):403-18. PubMed ID: 10873473
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
    Maga G; Amacker M; Hübscher U; Gosselin G; Imbach JL; Mathé C; Faraj A; Sommadossi JP; Spadari S
    Nucleic Acids Res; 1999 Feb; 27(4):972-8. PubMed ID: 9927728
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase.
    Feng JY; Anderson KS
    Biochemistry; 1999 Jul; 38(29):9440-8. PubMed ID: 10413520
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.
    Jeffrey JL; Feng JY; Qi CC; Anderson KS; Furman PA
    J Biol Chem; 2003 May; 278(21):18971-9. PubMed ID: 12651859
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.
    Feng JY; Johnson AA; Johnson KA; Anderson KS
    J Biol Chem; 2001 Jun; 276(26):23832-7. PubMed ID: 11328813
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
    Nakajima S; Watashi K; Kato T; Muramatsu M; Wakita T; Tamura N; Hattori SI; Maeda K; Mitsuya H; Yasutake Y; Toyoda T
    J Virol; 2021 Jul; 95(16):e0240120. PubMed ID: 34076480
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
    Erickson-Viitanen S; Wu JT; Shi G; Unger S; King RW; Fish B; Klabe R; Geleziunas R; Gallagher K; Otto MJ; Schinazi RF
    Antivir Chem Chemother; 2003 Jan; 14(1):39-47. PubMed ID: 12790515
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine.
    Hernandez-Santiago BI; Mathew JS; Rapp KL; Grier JP; Schinazi RF
    Antimicrob Agents Chemother; 2007 Jun; 51(6):2130-5. PubMed ID: 17403996
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.