These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 12413835)

  • 1. Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity.
    Bojarski AJ; Kowalski P; Kowalska T; Duszyńska B; Charakchieva-Minol S; Tatarczyńska E; Kłodzińska A; Chojnacka-Wójcik E
    Bioorg Med Chem; 2002 Dec; 10(12):3817-27. PubMed ID: 12413835
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S; Kołaczkowski M; Maryniak E; Zajdel P; Pawłowski M; Tatarczyńska E; Kłodzińska A; Chojnacka-Wójcik E; Bojarski AJ; Charakchieva-Minol S; Duszyńska B; Nowak G; Maciag D
    J Med Chem; 2004 May; 47(10):2659-66. PubMed ID: 15115407
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
    Zajdel P; Subra G; Bojarski AJ; Duszyńska B; Tatarczyńska E; Nikiforuk A; Chojnacka-Wójcik E; Pawłowski M; Martinez J
    Bioorg Med Chem; 2007 Apr; 15(8):2907-19. PubMed ID: 17321139
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and 5-HT(1A), 5-HT(2A) receptor activity of new beta-tetralonohydantoins.
    Byrtus H; Pawłowski M; Czopek A; Bojarski AJ; Duszyńska B; Nowak G; Kłodzińska A; Tatarczyńska E; Wesołowska A; Chojnacka-Wójcik E
    Eur J Med Chem; 2005 Aug; 40(8):820-9. PubMed ID: 16122584
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.
    López-Rodríguez ML; Morcillo MJ; Fernández E; Porras E; Orensanz L; Beneytez ME; Manzanares J; Fuentes JA
    J Med Chem; 2001 Jan; 44(2):186-97. PubMed ID: 11170628
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Active conformation of some arylpiperazine postsynaptic 5-HT(1A) receptor antagonists.
    Paluchowska MH; Bojarski AJ; Charakchieva-Minol S; Wesołowska A
    Eur J Med Chem; 2002 Apr; 37(4):273-83. PubMed ID: 11960662
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Modification of the structure of 4, 6-disubstituted 2-(4-alkyl-1-piperazinyl)pyridines: synthesis and their 5-HT2A receptor activity.
    Paluchowska MH; Bojarski AJ; Bugno R; Charakchieva-Minol S; Wesołowska A
    Arch Pharm (Weinheim); 2003 Apr; 336(2):104-10. PubMed ID: 12761763
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents.
    Dekeyne A; Brocco M; Adhumeau A; Gobert A; Millan MJ
    Psychopharmacology (Berl); 2000 Sep; 152(1):55-66. PubMed ID: 11041316
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
    Asproni B; Pau A; Bitti M; Melosu M; Cerri R; Dazzi L; Seu E; Maciocco E; Sanna E; Busonero F; Talani G; Pusceddu L; Altomare C; Trapani G; Biggio G
    J Med Chem; 2002 Oct; 45(21):4655-68. PubMed ID: 12361392
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
    Peglion JL; Goument B; Despaux N; Charlot V; Giraud H; Nisole C; Newman-Tancredi A; Dekeyne A; Bertrand M; Genissel P; Millan MJ
    J Med Chem; 2002 Jan; 45(1):165-76. PubMed ID: 11754589
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity.
    Bojarski AJ; Paluchowska MH; Duszyńska B; Bugno R; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
    Bioorg Med Chem; 2006 Mar; 14(5):1391-402. PubMed ID: 16266808
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
    Chłoń-Rzepa G; Zmudzki P; Zajdel P; Bojarski AJ; Duszyńska B; Nikiforuk A; Tatarczyńska E; Pawłowski M
    Bioorg Med Chem; 2007 Aug; 15(15):5239-50. PubMed ID: 17517514
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis by microwave irradiation and binding properties of novel 5-HT(1A) receptor ligands.
    Caliendo G; Fiorino F; Perissutti E; Severino B; Gessi S; Cattabriga E; Borea PA; Santagada V
    Eur J Med Chem; 2001; 36(11-12):873-86. PubMed ID: 11755230
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of several 5-hydroxytryptamine(1A) receptor ligands on the micturition reflex in rats: comparison with WAY 100635.
    Testa R; Guarneri L; Poggesi E; Angelico P; Velasco C; Ibba M; Cilia A; Motta G; Riva C; Leonardi A
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1258-69. PubMed ID: 10454502
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
    Campiani G; Morelli E; Gemma S; Nacci V; Butini S; Hamon M; Novellino E; Greco G; Cagnotto A; Goegan M; Cervo L; Dalla Valle F; Fracasso C; Caccia S; Mennini T
    J Med Chem; 1999 Oct; 42(21):4362-79. PubMed ID: 10543880
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione.
    Chloń G; Pawłowski M; Duszyńska B; Szaro A; Tatarczńska E; Kłodzińska AL; Chojnacka-Wójcik E
    Pol J Pharmacol; 2001; 53(4):359-68. PubMed ID: 11990082
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ; Paluchowska MH; Duszyńska B; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
    Bioorg Med Chem; 2005 Mar; 13(6):2293-303. PubMed ID: 15727878
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Arylpiperazine derivatives acting at 5-HT(1A) receptors.
    López-Rodríguez ML; Ayala D; Benhamú B; Morcillo MJ; Viso A
    Curr Med Chem; 2002 Feb; 9(4):443-69. PubMed ID: 11945120
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.
    López-Rodríguez ML; Morcillo MJ; Fernández E; Benhamú B; Tejada I; Ayala D; Viso A; Olivella M; Pardo L; Delgado M; Manzanares J; Fuentes JA
    Bioorg Med Chem Lett; 2003 Apr; 13(8):1429-32. PubMed ID: 12668005
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.
    López-Rodríguez ML; Morcillo MJ; Fernández E; Rosado ML; Pardo L; Schaper K
    J Med Chem; 2001 Jan; 44(2):198-207. PubMed ID: 11170629
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.