875 related articles for article (PubMed ID: 12414725)
1. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Chen JK; Taipale J; Cooper MK; Beachy PA
Genes Dev; 2002 Nov; 16(21):2743-8. PubMed ID: 12414725
[TBL] [Abstract][Full Text] [Related]
2. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Taipale J; Chen JK; Cooper MK; Wang B; Mann RK; Milenkovic L; Scott MP; Beachy PA
Nature; 2000 Aug; 406(6799):1005-9. PubMed ID: 10984056
[TBL] [Abstract][Full Text] [Related]
3. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
Galimberti F; Busch AM; Chinyengetere F; Ma T; Sekula D; Memoli VA; Dragnev KH; Liu F; Johnson KC; Guo Y; Freemantle SJ; Andrew AS; Greninger P; Robbins DJ; Settleman J; Benes C; Dmitrovsky E
Int J Oncol; 2012 Nov; 41(5):1751-61. PubMed ID: 22923130
[TBL] [Abstract][Full Text] [Related]
4. Roughing up Smoothened: chemical modulators of hedgehog signaling.
King RW
J Biol; 2002 Nov; 1(2):8. PubMed ID: 12437769
[TBL] [Abstract][Full Text] [Related]
5. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
Peluso MO; Campbell VT; Harari JA; Tibbitts TT; Proctor JL; Whitebread N; Conley JM; White KF; Kutok JL; Read MA; McGovern K; Faia KL
PLoS One; 2014; 9(3):e90534. PubMed ID: 24608250
[TBL] [Abstract][Full Text] [Related]
6. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.
Jaskoll T; Leo T; Witcher D; Ormestad M; Astorga J; Bringas P; Carlsson P; Melnick M
Dev Dyn; 2004 Apr; 229(4):722-32. PubMed ID: 15042696
[TBL] [Abstract][Full Text] [Related]
7. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
Incardona JP; Gaffield W; Kapur RP; Roelink H
Development; 1998 Sep; 125(18):3553-62. PubMed ID: 9716521
[TBL] [Abstract][Full Text] [Related]
8. Small molecule modulation of Smoothened activity.
Chen JK; Taipale J; Young KE; Maiti T; Beachy PA
Proc Natl Acad Sci U S A; 2002 Oct; 99(22):14071-6. PubMed ID: 12391318
[TBL] [Abstract][Full Text] [Related]
9. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine.
Kozielewicz P; Bowin CF; Turku A; Schulte G
Mol Pharmacol; 2020 Jan; 97(1):23-34. PubMed ID: 31707356
[TBL] [Abstract][Full Text] [Related]
10. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Masdeu C; Faure H; Coulombe J; Schoenfelder A; Mann A; Brabet I; Pin JP; Traiffort E; Ruat M
Biochem Biophys Res Commun; 2006 Oct; 349(2):471-9. PubMed ID: 16945339
[TBL] [Abstract][Full Text] [Related]
11. Smoothened as a new therapeutic target for human osteosarcoma.
Hirotsu M; Setoguchi T; Sasaki H; Matsunoshita Y; Gao H; Nagao H; Kunigou O; Komiya S
Mol Cancer; 2010 Jan; 9():5. PubMed ID: 20067614
[TBL] [Abstract][Full Text] [Related]
12. Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).
Zhang X; Harrington N; Moraes RC; Wu MF; Hilsenbeck SG; Lewis MT
Breast Cancer Res Treat; 2009 Jun; 115(3):505-21. PubMed ID: 18563554
[TBL] [Abstract][Full Text] [Related]
13. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Chen W; Ren XR; Nelson CD; Barak LS; Chen JK; Beachy PA; de Sauvage F; Lefkowitz RJ
Science; 2004 Dec; 306(5705):2257-60. PubMed ID: 15618519
[TBL] [Abstract][Full Text] [Related]
14. Evaluation of cytotoxic properties of a cyclopamine glucuronide prodrug in rat glioblastoma cells and tumors.
Bensalma S; Chadeneau C; Legigan T; Renoux B; Gaillard A; de Boisvilliers M; Pinet-Charvet C; Papot S; Muller JM
J Mol Neurosci; 2015 Jan; 55(1):51-61. PubMed ID: 25280457
[TBL] [Abstract][Full Text] [Related]
15. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.
Chen JK
Nat Prod Rep; 2016 May; 33(5):595-601. PubMed ID: 26787175
[TBL] [Abstract][Full Text] [Related]
16. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Roudaut H; Traiffort E; Gorojankina T; Vincent L; Faure H; Schoenfelder A; Mann A; Manetti F; Solinas A; Taddei M; Ruat M
Mol Pharmacol; 2011 Mar; 79(3):453-60. PubMed ID: 21177415
[TBL] [Abstract][Full Text] [Related]
17. Expression of hedgehog signalling pathway in anaplastic thyroid cancer.
Hinterseher U; Wunderlich A; Roth S; Ramaswamy A; Bartsch DK; Hauptmann S; Greene BH; Fendrich V; Hoffmann S
Endocrine; 2014 Apr; 45(3):439-47. PubMed ID: 23860623
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis.
Athar M; Li C; Tang X; Chi S; Zhang X; Kim AL; Tyring SK; Kopelovich L; Hebert J; Epstein EH; Bickers DR; Xie J
Cancer Res; 2004 Oct; 64(20):7545-52. PubMed ID: 15492281
[TBL] [Abstract][Full Text] [Related]
19. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.
Wang Y; Zhou Z; Walsh CT; McMahon AP
Proc Natl Acad Sci U S A; 2009 Feb; 106(8):2623-8. PubMed ID: 19196978
[TBL] [Abstract][Full Text] [Related]
20. Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling.
Fan Q; Gu D; He M; Liu H; Sheng T; Xie G; Li CX; Zhang X; Wainwright B; Garrossian A; Garrossian M; Gardner D; Xie J
Chin J Cancer; 2011 Jul; 30(7):472-81. PubMed ID: 21718593
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
