These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 12419216)

  • 1. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.
    Lax I; Wong A; Lamothe B; Lee A; Frost A; Hawes J; Schlessinger J
    Mol Cell; 2002 Oct; 10(4):709-19. PubMed ID: 12419216
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
    Ong SH; Hadari YR; Gotoh N; Guy GR; Schlessinger J; Lax I
    Proc Natl Acad Sci U S A; 2001 May; 98(11):6074-9. PubMed ID: 11353842
    [TBL] [Abstract][Full Text] [Related]  

  • 3. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
    Wu Y; Chen Z; Ullrich A
    Biol Chem; 2003 Aug; 384(8):1215-26. PubMed ID: 12974390
    [TBL] [Abstract][Full Text] [Related]  

  • 4. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
    Ong SH; Guy GR; Hadari YR; Laks S; Gotoh N; Schlessinger J; Lax I
    Mol Cell Biol; 2000 Feb; 20(3):979-89. PubMed ID: 10629055
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
    Hadari YR; Kouhara H; Lax I; Schlessinger J
    Mol Cell Biol; 1998 Jul; 18(7):3966-73. PubMed ID: 9632781
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
    Zhang Y; McKeehan K; Lin Y; Zhang J; Wang F
    Mol Endocrinol; 2008 Jan; 22(1):167-75. PubMed ID: 17901128
    [TBL] [Abstract][Full Text] [Related]  

  • 7. FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway.
    Zhou W; Feng X; Wu Y; Benge J; Zhang Z; Chen Z
    Cell Res; 2009 Oct; 19(10):1165-77. PubMed ID: 19652666
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
    Cross MJ; Lu L; Magnusson P; Nyqvist D; Holmqvist K; Welsh M; Claesson-Welsh L
    Mol Biol Cell; 2002 Aug; 13(8):2881-93. PubMed ID: 12181353
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR.
    Wang X; Weng LP; Yu Q
    Oncogene; 2000 May; 19(19):2346-53. PubMed ID: 10822386
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
    Hanafusa H; Torii S; Yasunaga T; Nishida E
    Nat Cell Biol; 2002 Nov; 4(11):850-8. PubMed ID: 12402043
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.
    Gotoh N; Ito M; Yamamoto S; Yoshino I; Song N; Wang Y; Lax I; Schlessinger J; Shibuya M; Lang RA
    Proc Natl Acad Sci U S A; 2004 Dec; 101(49):17144-9. PubMed ID: 15569927
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
    Kouhara H; Hadari YR; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J
    Cell; 1997 May; 89(5):693-702. PubMed ID: 9182757
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.
    Hadari YR; Gotoh N; Kouhara H; Lax I; Schlessinger J
    Proc Natl Acad Sci U S A; 2001 Jul; 98(15):8578-83. PubMed ID: 11447289
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression.
    Li Q; Alsaidan OA; Ma Y; Kim S; Liu J; Albers T; Liu K; Beharry Z; Zhao S; Wang F; Lebedyeva I; Cai H
    J Biol Chem; 2018 Apr; 293(17):6434-6448. PubMed ID: 29540482
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.
    Li H; Tao C; Cai Z; Hertzler-Schaefer K; Collins TN; Wang F; Feng GS; Gotoh N; Zhang X
    J Cell Sci; 2014 Feb; 127(Pt 3):571-82. PubMed ID: 24284065
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation.
    Klint P; Kanda S; Kloog Y; Claesson-Welsh L
    Oncogene; 1999 Jun; 18(22):3354-64. PubMed ID: 10362356
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.
    Haling JR; Wang F; Ginsberg MH
    Mol Biol Cell; 2010 Feb; 21(4):664-73. PubMed ID: 20032303
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
    Melillo RM; Santoro M; Ong SH; Billaud M; Fusco A; Hadari YR; Schlessinger J; Lax I
    Mol Cell Biol; 2001 Jul; 21(13):4177-87. PubMed ID: 11390647
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α.
    Barylko B; Chen YJ; Hennen J; Angert I; Chen Y; Mueller JD; Sun HQ; Taylor CA; Liou J; Yin H; Albanesi JP
    Biochemistry; 2019 Jun; 58(25):2809-2813. PubMed ID: 31184863
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation.
    Kovalenko D; Yang X; Nadeau RJ; Harkins LK; Friesel R
    J Biol Chem; 2003 Apr; 278(16):14087-91. PubMed ID: 12604616
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.