These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation. Song X; Xu CR; He HT; Siahaan TJ Bioorg Chem; 2002 Aug; 30(4):285-301. PubMed ID: 12392707 [TBL] [Abstract][Full Text] [Related]
5. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers. Wang B; Nimkar K; Wang W; Zhang H; Shan D; Gudmundsson O; Gangwar S; Siahaan T; Borchardt RT J Pept Res; 1999 Apr; 53(4):370-82. PubMed ID: 10406215 [TBL] [Abstract][Full Text] [Related]
6. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation. Gudmundsson OS; Nimkar K; Gangwar S; Siahaan T; Borchardt RT Pharm Res; 1999 Jan; 16(1):16-23. PubMed ID: 9950273 [TBL] [Abstract][Full Text] [Related]
7. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide. Pauletti GM; Gangwar S; Okumu FW; Siahaan TJ; Stella VJ; Borchardt RT Pharm Res; 1996 Nov; 13(11):1615-23. PubMed ID: 8956324 [TBL] [Abstract][Full Text] [Related]
8. A new acivicin prodrug designed for tumor-targeted delivery. Antczak C; Bauvois B; Monneret C; Florent JC Bioorg Med Chem; 2001 Nov; 9(11):2843-8. PubMed ID: 11597464 [TBL] [Abstract][Full Text] [Related]
9. Evaluating prodrug strategies for esterase-triggered release of alcohols. Perez C; Daniel KB; Cohen SM ChemMedChem; 2013 Oct; 8(10):1662-7. PubMed ID: 23929690 [TBL] [Abstract][Full Text] [Related]
10. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human. Liederer BM; Borchardt RT J Pharm Sci; 2005 Oct; 94(10):2198-206. PubMed ID: 16136552 [TBL] [Abstract][Full Text] [Related]
11. A prodrug system for hydroxylamines based on esterase catalysis. Conejo-Garcia A; Schofield CJ Bioorg Med Chem Lett; 2005 Sep; 15(18):4004-9. PubMed ID: 15990293 [TBL] [Abstract][Full Text] [Related]
12. Synthesis of haloperidol prodrugs and their hydrolysis by porcine liver esterase. Morris AP; Brain KR; Heard CM Drug Metab Lett; 2008 Dec; 2(4):275-9. PubMed ID: 19356105 [TBL] [Abstract][Full Text] [Related]
13. Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion. Ouyang H; Vander Velde DG; Borchardt RT; Siahaan TJ J Pept Res; 2002 Apr; 59(4):183-95. PubMed ID: 11972752 [TBL] [Abstract][Full Text] [Related]
14. Coumarin-based prodrugs. Part 3: Structural effects on the release kinetics of esterase-sensitive prodrugs of amines. Wang B; Zhang H; Zheng A; Wang W Bioorg Med Chem; 1998 Apr; 6(4):417-26. PubMed ID: 9597186 [TBL] [Abstract][Full Text] [Related]
15. Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates. Liao Y; Wang B Bioorg Med Chem Lett; 1999 Jul; 9(13):1795-800. PubMed ID: 10406644 [TBL] [Abstract][Full Text] [Related]
16. Stereospecific activity and nature of metabolizing esterases for propranolol prodrug in hairless mouse skin, liver and plasma. Ahmed S; Imai T; Yoshigae Y; Otagiri M Life Sci; 1997; 61(19):1879-87. PubMed ID: 9364192 [TBL] [Abstract][Full Text] [Related]
17. Amine prodrugs which utilize hydroxy amide lactonization. I. A potential redox-sensitive amide prodrug. Amsberry KL; Borchardt RT Pharm Res; 1991 Mar; 8(3):323-30. PubMed ID: 2052518 [TBL] [Abstract][Full Text] [Related]
18. Synthesis of cyclic prodrugs of Aggrastat and its analogue with a modified phenylpropionic acid linker. Song X; He HT; Siahaan TJ Org Lett; 2002 Feb; 4(4):549-52. PubMed ID: 11843588 [TBL] [Abstract][Full Text] [Related]
20. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs. Yang JZ; Chen W; Borchardt RT J Pharmacol Exp Ther; 2002 Nov; 303(2):840-8. PubMed ID: 12388671 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]