These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

107 related articles for article (PubMed ID: 12419379)

  • 21. Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.
    Singh R; Kumar V; Bharate SS; Vishwakarma RA
    Bioorg Med Chem; 2017 Oct; 25(20):5513-5521. PubMed ID: 28843845
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
    Liederer BM; Phan KT; Ouyang H; Borchardt RT
    J Pharm Sci; 2005 Dec; 94(12):2676-87. PubMed ID: 16258984
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and evaluation of novel coumarin-based esterase-sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability.
    Wang B; Wang W; Camenisch GP; Elmo J; Zhang H; Borchardt RT
    Chem Pharm Bull (Tokyo); 1999 Jan; 47(1):90-5. PubMed ID: 9987829
    [TBL] [Abstract][Full Text] [Related]  

  • 24. DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors.
    D'Arienzo CJ; Ji QC; Discenza L; Cornelius G; Hynes J; Cornelius L; Santella JB; Olah T
    Bioanalysis; 2010 Aug; 2(8):1415-22. PubMed ID: 21083342
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Specificity of esterases and structures of prodrug esters. III. Activity of rat tissue homogenates, rat plasma and porcine liver esterase for the hydrolysis of 3',5'-bis-dicarboxylic acid hemiesters of 5-fluoro-2'-deoxyuridine.
    Kawaguchi T; Suzuki Y; Nambu N; Nagai T
    Chem Pharm Bull (Tokyo); 1985 Jul; 33(7):2956-61. PubMed ID: 2935265
    [No Abstract]   [Full Text] [Related]  

  • 26. Neighboring group catalysis in the design of nucleotide prodrugs.
    Khamnei S; Torrence PF
    J Med Chem; 1996 Sep; 39(20):4109-15. PubMed ID: 8831776
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins.
    He X; Lu W; Jiang X; Cai J; Zhang X; Ding J
    Bioorg Med Chem; 2004 Aug; 12(15):4003-8. PubMed ID: 15246077
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Esterase inhibition attribute of grapefruit juice leading to a new drug interaction.
    Li P; Callery PS; Gan LS; Balani SK
    Drug Metab Dispos; 2007 Jul; 35(7):1023-31. PubMed ID: 17392396
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.
    Bak A; Siahaan TJ; Gudmundsson OS; Gangwar S; Friis GJ; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):393-402. PubMed ID: 10406217
    [TBL] [Abstract][Full Text] [Related]  

  • 30. N-hydroxybenzenecarboximidic acid derivatives: a new class of nitroxyl-generating prodrugs.
    Lee MJ; Shoeman DW; Goon DJ; Nagasawa HT
    Nitric Oxide; 2001 Jun; 5(3):278-87. PubMed ID: 11384201
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.
    Simões MF; Valente E; Gómez MJ; Anes E; Constantino L
    Eur J Pharm Sci; 2009 Jun; 37(3-4):257-63. PubMed ID: 19491013
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity.
    Redden PR; Melanson RL; Douglas JA; Dick AJ
    Int J Pharm; 1999 Apr; 180(2):151-60. PubMed ID: 10370185
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.
    Ohura K; Nakada Y; Kotani S; Imai T
    J Pharm Sci; 2015 Sep; 104(9):3076-83. PubMed ID: 25953731
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A; Gudmundsson OS; Friis GJ; Siahaan TJ; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Simultaneous determination of curcumin diethyl disuccinate and its active metabolite curcumin in rat plasma by LC-MS/MS: Application of esterase inhibitors in the stabilization of an ester-containing prodrug.
    Ratnatilaka Na Bhuket P; Niwattisaiwong N; Limpikirati P; Khemawoot P; Towiwat P; Ongpipattanakul B; Rojsitthisak P
    J Chromatogr B Analyt Technol Biomed Life Sci; 2016 Oct; 1033-1034():301-310. PubMed ID: 27595650
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation.
    Park JH; Chang JS; El-Gamal MI; Choi WK; Lee WS; Chung HJ; Kim HI; Cho YJ; Lee BS; Jeon HR; Lee YS; Choi YW; Lee J; Oh CH
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5895-9. PubMed ID: 20728357
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Detoxification of organophosphates by A-esterases in human serum.
    Sams C; Mason HJ
    Hum Exp Toxicol; 1999 Nov; 18(11):653-8. PubMed ID: 10602389
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Vitamin K prodrugs: 1. Synthesis of amino acid esters of menahydroquinone-4 and enzymatic reconversion to an active form.
    Takata J; Karube Y; Hanada M; Matsunaga K; Matsushima Y; Sendo T; Aoyama T
    Pharm Res; 1995 Jan; 12(1):18-23. PubMed ID: 7724483
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril.
    Eichenbaum G; Skibbe J; Parkinson A; Johnson MD; Baumgardner D; Ogilvie B; Usuki E; Tonelli F; Holsapple J; Schmitt-Hoffmann A
    J Pharm Sci; 2012 Mar; 101(3):1242-52. PubMed ID: 22095741
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.
    Gudmundsson OS; Pauletti GM; Wang W; Shan D; Zhang H; Wang B; Borchardt RT
    Pharm Res; 1999 Jan; 16(1):7-15. PubMed ID: 9950272
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.