These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 12423165)

  • 1. S-homoadenosyl-L-cysteine and S-homoadenosyl-L-homocysteine. Synthesis and binding studies of hon-hydrolyzed substrate analogues with S-adenosyl-L-homocysteine hydrolase.
    Miles RW; Nielsen LP; Ewing GJ; Yin D; Borchardt RT; Robins MJ
    J Org Chem; 2002 Nov; 67(23):8258-60. PubMed ID: 12423165
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).
    Robins MJ; Wnuk SF; Yang X; Yuan CS; Borchardt RT; Balzarini J; De Clercq E
    J Med Chem; 1998 Sep; 41(20):3857-64. PubMed ID: 9748360
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of homologated halovinyl derivatives from aristeromycin and their inhibition of human placental S-adenosyl-L-homocysteine hydrolase.
    Wnuk SF; Yuan CS; Borchardt RT; Robins MJ
    Nucleosides Nucleotides; 1998; 17(1-3):99-113. PubMed ID: 9708344
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of inactivation of S-adenosyl-L-homocysteine hydrolase by 5'-deoxy-5'-S-allenylthioadenosine and 5'-deoxy-5'-S-propynylthioadenosine.
    Guillerm G; Guillerm D; Witkowski-Vandenplas C
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):685-8. PubMed ID: 11563092
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.
    Wnuk SF; Valdez CA; Khan J; Moutinho P; Robins MJ; Yang X; Borchardt RT; Balzarini J; De Clercq E
    J Med Chem; 2000 Mar; 43(6):1180-6. PubMed ID: 10737751
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine.
    Wnuk SF; Mao Y; Yuan CS; Borchardt RT; Andrei G; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1998 Jul; 41(16):3078-83. PubMed ID: 9685247
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inactivation of S-adenosyl-L-homocysteine hydrolase with fluorinated analogs of 2'- and 3'-deoxy-5'-methylthioadenosine.
    Guillerm D; Guillerm G; Witkowski-Vandenplas C
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):689-93. PubMed ID: 11563093
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substrate specificity of S-adenosylhomocysteinase. Cysteine is a substrate of the plant and mammalian enzymes.
    Guranowski A; Jakubowski H
    Biochim Biophys Acta; 1983 Jan; 742(1):250-6. PubMed ID: 6824685
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.
    Wnuk SF
    Mini Rev Med Chem; 2001 Sep; 1(3):307-16. PubMed ID: 12369977
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
    Wnuk SF; Yuan CS; Borchardt RT; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1994 Oct; 37(21):3579-87. PubMed ID: 7932585
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
    Wnuk SF; Yuan CS; Borchardt RT; Balzarini J; De Clercq E; Robins MJ
    J Med Chem; 1997 May; 40(11):1608-18. PubMed ID: 9171871
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Purification and properties of S-adenosyl-L-homocysteine hydrolase from leaves of spinach beet.
    Poulton JE; Butt VS
    Arch Biochem Biophys; 1976 Jan; 172(1):135-42. PubMed ID: 3135
    [No Abstract]   [Full Text] [Related]  

  • 13. S-Inosyl-L-Homocysteine Hydrolase, a Novel Enzyme Involved in S-Adenosyl-L-Methionine Recycling.
    Miller D; Xu H; White RH
    J Bacteriol; 2015 Jul; 197(14):2284-91. PubMed ID: 25917907
    [TBL] [Abstract][Full Text] [Related]  

  • 14. S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors.
    Chiang PK; Richards HH; Cantoni GL
    Mol Pharmacol; 1977 Sep; 13(5):939-47. PubMed ID: 895724
    [No Abstract]   [Full Text] [Related]  

  • 15. Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogues that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase.
    Robins MJ; Samano V; Zhang W; Balzarini J; De Clercq E; Borchardt RT; Lee Y; Yuan CS
    J Med Chem; 1992 Jun; 35(12):2283-93. PubMed ID: 1613752
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
    Steere JA; Sampson PB; Honek JF
    Bioorg Med Chem Lett; 2002 Feb; 12(3):457-60. PubMed ID: 11814819
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.
    Kitade Y; Kozaki A; Gotoh T; Miwa T; Nakanishi M; Yatome C
    Nucleic Acids Symp Ser; 1999; (42):25-6. PubMed ID: 10780361
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine.
    Houston DM; Matuszewska B; Borchardt RT
    J Med Chem; 1985 Apr; 28(4):478-82. PubMed ID: 3981540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inactivation of S-adenosyl-L-homocysteine hydrolase by cAMP results from dissociation of enzyme-bound NAD+.
    Hohman RJ; Guitton MC; Veron M
    Proc Natl Acad Sci U S A; 1985 Jul; 82(14):4578-81. PubMed ID: 2991881
    [TBL] [Abstract][Full Text] [Related]  

  • 20. An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
    Manszewski T; Singh K; Imiolczyk B; Jaskolski M
    Acta Crystallogr D Biol Crystallogr; 2015 Dec; 71(Pt 12):2422-32. PubMed ID: 26627650
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.