BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

733 related articles for article (PubMed ID: 12437574)

  • 1. Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis.
    Urushitani M; Kurisu J; Tsukita K; Takahashi R
    J Neurochem; 2002 Dec; 83(5):1030-42. PubMed ID: 12437574
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.
    Turner BJ; Lopes EC; Cheema SS
    J Cell Biochem; 2004 Apr; 91(5):1074-84. PubMed ID: 15034941
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.
    Urushitani M; Kurisu J; Tateno M; Hatakeyama S; Nakayama K; Kato S; Takahashi R
    J Neurochem; 2004 Jul; 90(1):231-44. PubMed ID: 15198682
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.
    Jaarsma D; Haasdijk ED; Grashorn JA; Hawkins R; van Duijn W; Verspaget HW; London J; Holstege JC
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):623-43. PubMed ID: 11114261
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.
    Watanabe M; Dykes-Hoberg M; Culotta VC; Price DL; Wong PC; Rothstein JD
    Neurobiol Dis; 2001 Dec; 8(6):933-41. PubMed ID: 11741389
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes.
    Puttaparthi K; Wojcik C; Rajendran B; DeMartino GN; Elliott JL
    J Neurochem; 2003 Nov; 87(4):851-60. PubMed ID: 14622116
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis.
    Cheroni C; Marino M; Tortarolo M; Veglianese P; De Biasi S; Fontana E; Zuccarello LV; Maynard CJ; Dantuma NP; Bendotti C
    Hum Mol Genet; 2009 Jan; 18(1):82-96. PubMed ID: 18826962
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.
    Turner BJ; Atkin JD; Farg MA; Zang DW; Rembach A; Lopes EC; Patch JD; Hill AF; Cheema SS
    J Neurosci; 2005 Jan; 25(1):108-17. PubMed ID: 15634772
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes.
    Choi JS; Cho S; Park SG; Park BC; Lee DH
    Biochem Biophys Res Commun; 2004 Aug; 321(3):574-83. PubMed ID: 15358145
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
    Crippa V; Sau D; Rusmini P; Boncoraglio A; Onesto E; Bolzoni E; Galbiati M; Fontana E; Marino M; Carra S; Bendotti C; De Biasi S; Poletti A
    Hum Mol Genet; 2010 Sep; 19(17):3440-56. PubMed ID: 20570967
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells.
    Oh YK; Shin KS; Yuan J; Kang SJ
    J Neurochem; 2008 Feb; 104(4):993-1005. PubMed ID: 18233996
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.
    Urushitani M; Sik A; Sakurai T; Nukina N; Takahashi R; Julien JP
    Nat Neurosci; 2006 Jan; 9(1):108-18. PubMed ID: 16369483
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival.
    Liu R; Li B; Flanagan SW; Oberley LW; Gozal D; Qiu M
    J Neurochem; 2002 Feb; 80(3):488-500. PubMed ID: 11905995
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme.
    Prudencio M; Durazo A; Whitelegge JP; Borchelt DR
    J Neurochem; 2009 Feb; 108(4):1009-18. PubMed ID: 19077113
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation.
    Ezzi SA; Urushitani M; Julien JP
    J Neurochem; 2007 Jul; 102(1):170-8. PubMed ID: 17394546
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.
    Menzies FM; Cookson MR; Taylor RW; Turnbull DM; Chrzanowska-Lightowlers ZM; Dong L; Figlewicz DA; Shaw PJ
    Brain; 2002 Jul; 125(Pt 7):1522-33. PubMed ID: 12077002
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amyotrophic lateral sclerosis-related mutant superoxide dismutase 1 aggregates inhibit 14-3-3-mediated cell survival by sequestration into the JUNQ compartment.
    Park JH; Jang HR; Lee IY; Oh HK; Choi EJ; Rhim H; Kang S
    Hum Mol Genet; 2017 Sep; 26(18):3615-3629. PubMed ID: 28666328
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.
    Niwa J; Yamada S; Ishigaki S; Sone J; Takahashi M; Katsuno M; Tanaka F; Doyu M; Sobue G
    J Biol Chem; 2007 Sep; 282(38):28087-95. PubMed ID: 17666395
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Overexpressed wild-type superoxide dismutase 1 exhibits amyotrophic lateral sclerosis-related misfolded conformation in induced pluripotent stem cell-derived spinal motor neurons.
    Komatsu K; Imamura K; Yamashita H; Julien JP; Takahashi R; Inoue H
    Neuroreport; 2018 Jan; 29(1):25-29. PubMed ID: 29140847
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome.
    Cheroni C; Peviani M; Cascio P; Debiasi S; Monti C; Bendotti C
    Neurobiol Dis; 2005 Apr; 18(3):509-22. PubMed ID: 15755678
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 37.