141 related articles for article (PubMed ID: 12437577)
21. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF; Shah S; Li H; Yu C; Han W; Yu G
J Biol Chem; 2002 Nov; 277(47):45013-9. PubMed ID: 12297508
[TBL] [Abstract][Full Text] [Related]
22. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
Lopez-Perez E; Seidah NG; Checler F
J Neurochem; 1999 Nov; 73(5):2056-62. PubMed ID: 10537065
[TBL] [Abstract][Full Text] [Related]
23. Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.
Marambaud P; Ancolio K; Alves da Costa C; Checler F
Br J Pharmacol; 1999 Mar; 126(5):1186-90. PubMed ID: 10205007
[TBL] [Abstract][Full Text] [Related]
24. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
Beher D; Wrigley JD; Owens AP; Shearman MS
J Neurochem; 2002 Aug; 82(3):563-75. PubMed ID: 12153480
[TBL] [Abstract][Full Text] [Related]
25. Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Chami L; Buggia-Prévot V; Duplan E; Del Prete D; Chami M; Peyron JF; Checler F
J Biol Chem; 2012 Jul; 287(29):24573-84. PubMed ID: 22654105
[TBL] [Abstract][Full Text] [Related]
26. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
Okochi M; Steiner H; Fukumori A; Tanii H; Tomita T; Tanaka T; Iwatsubo T; Kudo T; Takeda M; Haass C
EMBO J; 2002 Oct; 21(20):5408-16. PubMed ID: 12374741
[TBL] [Abstract][Full Text] [Related]
27. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
[TBL] [Abstract][Full Text] [Related]
28. A non-amyloidogenic function of BACE-2 in the secretory pathway.
Fluhrer R; Capell A; Westmeyer G; Willem M; Hartung B; Condron MM; Teplow DB; Haass C; Walter J
J Neurochem; 2002 Jun; 81(5):1011-20. PubMed ID: 12065613
[TBL] [Abstract][Full Text] [Related]
29. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
[TBL] [Abstract][Full Text] [Related]
30. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
[TBL] [Abstract][Full Text] [Related]
31. Purification and characterization of the human gamma-secretase complex.
Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
[TBL] [Abstract][Full Text] [Related]
32. Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.
Stemmer N; Strekalova E; Djogo N; Plöger F; Loers G; Lutz D; Buck F; Michalak M; Schachner M; Kleene R
PLoS One; 2013; 8(4):e61299. PubMed ID: 23585889
[TBL] [Abstract][Full Text] [Related]
33. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
34. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
Lahiri DK; Farlow MR; Sambamurti K
Brain Res Mol Brain Res; 1998 Nov; 62(2):131-40. PubMed ID: 9813282
[TBL] [Abstract][Full Text] [Related]
35. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
Gu Y; Chen F; Sanjo N; Kawarai T; Hasegawa H; Duthie M; Li W; Ruan X; Luthra A; Mount HT; Tandon A; Fraser PE; St George-Hyslop P
J Biol Chem; 2003 Feb; 278(9):7374-80. PubMed ID: 12471034
[TBL] [Abstract][Full Text] [Related]
36. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
37. Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.
Meckler X; Roseman J; Das P; Cheng H; Pei S; Keat M; Kassarjian B; Golde TE; Parent AT; Thinakaran G
J Neurosci; 2010 Dec; 30(48):16160-9. PubMed ID: 21123562
[TBL] [Abstract][Full Text] [Related]
38. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.
Tomita T; Katayama R; Takikawa R; Iwatsubo T
FEBS Lett; 2002 Jun; 520(1-3):117-21. PubMed ID: 12044882
[TBL] [Abstract][Full Text] [Related]
39. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
40. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
King GD; Cherian K; Turner RS
J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
