141 related articles for article (PubMed ID: 12437769)
1. Roughing up Smoothened: chemical modulators of hedgehog signaling.
King RW
J Biol; 2002 Nov; 1(2):8. PubMed ID: 12437769
[TBL] [Abstract][Full Text] [Related]
2. Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha S; Chen JK
Nat Chem Biol; 2006 Jan; 2(1):29-30. PubMed ID: 16408088
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
Chen JK; Taipale J; Cooper MK; Beachy PA
Genes Dev; 2002 Nov; 16(21):2743-8. PubMed ID: 12414725
[TBL] [Abstract][Full Text] [Related]
4. Cancer: a twist in a hedgehog's tale.
Scott MP
Nature; 2003 Oct; 425(6960):780-2. PubMed ID: 14574396
[No Abstract] [Full Text] [Related]
5. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.
Frank-Kamenetsky M; Zhang XM; Bottega S; Guicherit O; Wichterle H; Dudek H; Bumcrot D; Wang FY; Jones S; Shulok J; Rubin LL; Porter JA
J Biol; 2002 Nov; 1(2):10. PubMed ID: 12437772
[TBL] [Abstract][Full Text] [Related]
6. Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Stanton BZ; Peng LF
Mol Biosyst; 2010 Jan; 6(1):44-54. PubMed ID: 20024066
[TBL] [Abstract][Full Text] [Related]
7. Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.
van der Horst G; Farih-Sips H; Löwik CW; Karperien M
Bone; 2003 Dec; 33(6):899-910. PubMed ID: 14678849
[TBL] [Abstract][Full Text] [Related]
8. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.
Jaskoll T; Leo T; Witcher D; Ormestad M; Astorga J; Bringas P; Carlsson P; Melnick M
Dev Dyn; 2004 Apr; 229(4):722-32. PubMed ID: 15042696
[TBL] [Abstract][Full Text] [Related]
9. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
Taipale J; Chen JK; Cooper MK; Wang B; Mann RK; Milenkovic L; Scott MP; Beachy PA
Nature; 2000 Aug; 406(6799):1005-9. PubMed ID: 10984056
[TBL] [Abstract][Full Text] [Related]
10. Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling.
Detmer K; Walker AN; Jenkins TM; Steele TA; Dannawi H
Blood Cells Mol Dis; 2000 Aug; 26(4):360-72. PubMed ID: 11042037
[TBL] [Abstract][Full Text] [Related]
11. Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity.
Tabs S; Avci O
Eur J Dermatol; 2004; 14(2):96-102. PubMed ID: 15196999
[TBL] [Abstract][Full Text] [Related]
12. Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).
Zhang X; Harrington N; Moraes RC; Wu MF; Hilsenbeck SG; Lewis MT
Breast Cancer Res Treat; 2009 Jun; 115(3):505-21. PubMed ID: 18563554
[TBL] [Abstract][Full Text] [Related]
13. Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling.
Fan Q; Gu D; He M; Liu H; Sheng T; Xie G; Li CX; Zhang X; Wainwright B; Garrossian A; Garrossian M; Gardner D; Xie J
Chin J Cancer; 2011 Jul; 30(7):472-81. PubMed ID: 21718593
[TBL] [Abstract][Full Text] [Related]
14. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.
Chen JK
Nat Prod Rep; 2016 May; 33(5):595-601. PubMed ID: 26787175
[TBL] [Abstract][Full Text] [Related]
15. Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
Galperin I; Dempwolff L; Diederich WE; Lauth M
J Med Chem; 2019 Sep; 62(18):8392-8411. PubMed ID: 30986059
[TBL] [Abstract][Full Text] [Related]
16. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.
Dwyer JR; Sever N; Carlson M; Nelson SF; Beachy PA; Parhami F
J Biol Chem; 2007 Mar; 282(12):8959-68. PubMed ID: 17200122
[TBL] [Abstract][Full Text] [Related]
17. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Chen W; Ren XR; Nelson CD; Barak LS; Chen JK; Beachy PA; de Sauvage F; Lefkowitz RJ
Science; 2004 Dec; 306(5705):2257-60. PubMed ID: 15618519
[TBL] [Abstract][Full Text] [Related]
18. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Masdeu C; Faure H; Coulombe J; Schoenfelder A; Mann A; Brabet I; Pin JP; Traiffort E; Ruat M
Biochem Biophys Res Commun; 2006 Oct; 349(2):471-9. PubMed ID: 16945339
[TBL] [Abstract][Full Text] [Related]
19. Targeting the hedgehog signaling pathway with small molecules.
Kiselyov AS
Anticancer Agents Med Chem; 2006 Sep; 6(5):445-9. PubMed ID: 17017853
[TBL] [Abstract][Full Text] [Related]
20. Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chemotherapeutic effects.
Mozet C; Stoehr M; Dimitrova K; Dietz A; Wichmann G
Anticancer Res; 2013 Jun; 33(6):2415-24. PubMed ID: 23749890
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
