These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 12443784)

  • 1. Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group.
    Smith HK; Beckett RP; Clements JM; Doel S; East SP; Launchbury SB; Pratt LM; Spavold ZM; Thomas W; Todd RS; Whittaker M
    Bioorg Med Chem Lett; 2002 Dec; 12(24):3595-9. PubMed ID: 12443784
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
    Pratt LM; Beckett RP; Davies SJ; Launchbury SB; Miller A; Spavold ZM; Todd RS; Whittaker M
    Bioorg Med Chem Lett; 2001 Oct; 11(19):2585-8. PubMed ID: 11551755
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.
    Davies SJ; Ayscough AP; Beckett RP; Bragg RA; Clements JM; Doel S; Grew C; Launchbury SB; Perkins GM; Pratt LM; Smith HK; Spavold ZM; Thomas SW; Todd RS; Whittaker M
    Bioorg Med Chem Lett; 2003 Aug; 13(16):2709-13. PubMed ID: 12873499
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
    Clements JM; Beckett RP; Brown A; Catlin G; Lobell M; Palan S; Thomas W; Whittaker M; Wood S; Salama S; Baker PJ; Rodgers HF; Barynin V; Rice DW; Hunter MG
    Antimicrob Agents Chemother; 2001 Feb; 45(2):563-70. PubMed ID: 11158755
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains.
    Davies SJ; Ayscough AP; Beckett RP; Clements JM; Doel S; Pratt LM; Spavold ZM; Thomas SW; Whittaker M
    Bioorg Med Chem Lett; 2003 Aug; 13(16):2715-8. PubMed ID: 12873500
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Peptide deformylase inhibitors with non-peptide scaffold: synthesis and structure-activity relationships.
    Lee SK; Choi KH; Lee SJ; Lee JS; Park JY; Kim BM; Lee BJ
    Bioorg Med Chem Lett; 2011 Jan; 21(1):133-6. PubMed ID: 21146987
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition.
    Thorarensen A; Deibel MR; Rohrer DC; Vosters AF; Yem AW; Marshall VD; Lynn JC; Bohanon MJ; Tomich PK; Zurenko GE; Sweeney MT; Jensen RM; Nielsen JW; Seest EP; Dolak LA
    Bioorg Med Chem Lett; 2001 Jun; 11(11):1355-8. PubMed ID: 11378353
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.
    Apfel C; Banner DW; Bur D; Dietz M; Hirata T; Hubschwerlen C; Locher H; Page MG; Pirson W; Rossé G; Specklin JL
    J Med Chem; 2000 Jun; 43(12):2324-31. PubMed ID: 10882358
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydroxamic acids as potent inhibitors of Fe(II) and Mn(II) E. coli methionine aminopeptidase: biological activities and X-ray structures of oxazole hydroxamate-EcMetAP-Mn complexes.
    Huguet F; Melet A; Alves de Sousa R; Lieutaud A; Chevalier J; Maigre L; Deschamps P; Tomas A; Leulliot N; Pages JM; Artaud I
    ChemMedChem; 2012 Jun; 7(6):1020-30. PubMed ID: 22489069
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
    Hackbarth CJ; Chen DZ; Lewis JG; Clark K; Mangold JB; Cramer JA; Margolis PS; Wang W; Koehn J; Wu C; Lopez S; Withers G; Gu H; Dunn E; Kulathila R; Pan SH; Porter WL; Jacobs J; Trias J; Patel DV; Weidmann B; White RJ; Yuan Z
    Antimicrob Agents Chemother; 2002 Sep; 46(9):2752-64. PubMed ID: 12183225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.
    Chen DZ; Patel DV; Hackbarth CJ; Wang W; Dreyer G; Young DC; Margolis PS; Wu C; Ni ZJ; Trias J; White RJ; Yuan Z
    Biochemistry; 2000 Feb; 39(6):1256-62. PubMed ID: 10684604
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.
    Apfel C; Banner DW; Bur D; Dietz M; Hubschwerlen C; Locher H; Marlin F; Masciadri R; Pirson W; Stalder H
    J Med Chem; 2001 Jun; 44(12):1847-52. PubMed ID: 11384231
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 2D-QSAR in hydroxamic acid derivatives as peptide deformylase inhibitors and antibacterial agents.
    Gupta MK; Mishra P; Prathipati P; Saxena AK
    Bioorg Med Chem; 2002 Dec; 10(12):3713-6. PubMed ID: 12413827
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Peptide deformylase inhibitors with retro-amide scaffold: synthesis and structure-activity relationships.
    Lee SK; Choi KH; Lee SJ; Suh SW; Kim BM; Lee BJ
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4317-9. PubMed ID: 20615695
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and antibacterial activity of peptide deformylase inhibitors.
    Huntington KM; Yi T; Wei Y; Pei D
    Biochemistry; 2000 Apr; 39(15):4543-51. PubMed ID: 10758004
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alpha-substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents.
    Jain R; Sundram A; Lopez S; Neckermann G; Wu C; Hackbarth C; Chen D; Wang W; Ryder NS; Weidmann B; Patel D; Trias J; White R; Yuan Z
    Bioorg Med Chem Lett; 2003 Dec; 13(23):4223-8. PubMed ID: 14623006
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design of a macrocyclic inhibitor for peptide deformylase.
    Hu X; Nguyen KT; Verlinde CL; Hol WG; Pei D
    J Med Chem; 2003 Aug; 46(18):3771-4. PubMed ID: 12930137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, Synthesis, and Biological Evaluation of Vanillin Hydroxamic Acid Derivatives as Novel Peptide Deformylase Inhibitors.
    Gao J; Qiu S; Liang L; Hao Z; Zhou Q; Wang F; Mou J; Lin Q
    Curr Comput Aided Drug Des; 2018; 14(1):95-101. PubMed ID: 28606047
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition and structure-activity studies of methionine hydroxamic acid derivatives with bacterial peptide deformylase.
    Grant SK; Green BG; Kozarich JW
    Bioorg Chem; 2001 Aug; 29(4):211-22. PubMed ID: 16256693
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel approaches to antimicrobial therapy: peptide deformylase.
    Waller AS; Clements JM
    Curr Opin Drug Discov Devel; 2002 Sep; 5(5):785-92. PubMed ID: 12630299
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.