262 related articles for article (PubMed ID: 12446594)
1. Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.
Arlt W; Martens JW; Song M; Wang JT; Auchus RJ; Miller WL
Endocrinology; 2002 Dec; 143(12):4665-72. PubMed ID: 12446594
[TBL] [Abstract][Full Text] [Related]
2. Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis.
Cloutier M; Fleury A; Courtemanche J; Ducharme L; Mason JI; Lehoux JG
DNA Cell Biol; 1997 Mar; 16(3):357-68. PubMed ID: 9115645
[TBL] [Abstract][Full Text] [Related]
3. Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17).
Swart AC; Kolar NW; Lombard N; Mason JI; Swart P
Eur J Biochem; 2002 Nov; 269(22):5608-16. PubMed ID: 12423360
[TBL] [Abstract][Full Text] [Related]
4. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
[TBL] [Abstract][Full Text] [Related]
5. Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme.
Tremblay Y; Fleury A; Beaudoin C; Vallée M; Bélanger A
DNA Cell Biol; 1994 Dec; 13(12):1199-212. PubMed ID: 7811386
[TBL] [Abstract][Full Text] [Related]
6. Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis.
Beaudoin C; Lavallée B; Tremblay Y; Hum DW; Breton R; de Launoit Y; Bélanger A
DNA Cell Biol; 1998 Aug; 17(8):707-15. PubMed ID: 9726253
[TBL] [Abstract][Full Text] [Related]
7. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.
Lin D; Black SM; Nagahama Y; Miller WL
Endocrinology; 1993 Jun; 132(6):2498-506. PubMed ID: 8504753
[TBL] [Abstract][Full Text] [Related]
8. Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency.
Gupta MK; Geller DH; Auchus RJ
J Clin Endocrinol Metab; 2001 Sep; 86(9):4416-23. PubMed ID: 11549685
[TBL] [Abstract][Full Text] [Related]
9. Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of functional zonation.
Mesiano S; Coulter CL; Jaffe RB
J Clin Endocrinol Metab; 1993 Nov; 77(5):1184-9. PubMed ID: 8077311
[TBL] [Abstract][Full Text] [Related]
10. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
Geller DH; Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jan; 13(1):167-75. PubMed ID: 9892022
[TBL] [Abstract][Full Text] [Related]
11. The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques.
Nguyen AD; Corbin CJ; Pattison JC; Bird IM; Conley AJ
Endocrinology; 2009 Apr; 150(4):1748-56. PubMed ID: 19036885
[TBL] [Abstract][Full Text] [Related]
12. Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling.
Mathieu AP; Auchus RJ; LeHoux JG
J Steroid Biochem Mol Biol; 2002 Jan; 80(1):99-107. PubMed ID: 11867269
[TBL] [Abstract][Full Text] [Related]
13. A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase.
Swart AC; Storbeck KH; Swart P
J Steroid Biochem Mol Biol; 2010 Apr; 119(3-5):112-20. PubMed ID: 20043997
[TBL] [Abstract][Full Text] [Related]
14. Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity.
Souter I; Munir I; Mallick P; Weitsman SR; Geller DH; Magoffin DA
Fertil Steril; 2006 Apr; 85 Suppl 1():1290-9. PubMed ID: 16616104
[TBL] [Abstract][Full Text] [Related]
15. The molecular basis of isolated 17,20 lyase deficiency.
Miller WL; Geller DH; Auchus RJ
Endocr Res; 1998; 24(3-4):817-25. PubMed ID: 9888582
[TBL] [Abstract][Full Text] [Related]
16. The regulation of 17,20 lyase activity.
Miller WL; Auchus RJ; Geller DH
Steroids; 1997 Jan; 62(1):133-42. PubMed ID: 9029728
[TBL] [Abstract][Full Text] [Related]
17. Novel mutation of the CYP17 gene in two unrelated patients with combined 17alpha-hydroxylase/17,20-lyase deficiency: demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling.
Patocs A; Liko I; Varga I; Gergics P; Boros A; Futo L; Kun I; Bertalan R; Toth S; Pazmany T; Toth M; Szücs N; Horanyi J; Glaz E; Racz K
J Steroid Biochem Mol Biol; 2005 Nov; 97(3):257-65. PubMed ID: 16176874
[TBL] [Abstract][Full Text] [Related]
18. Characterization and expression of cDNAs encoding P450c17-II (cyp17a2) in Japanese eel during induced ovarian development.
Su T; Ijiri S; Kanbara H; Hagihara S; Wang DS; Adachi S
Gen Comp Endocrinol; 2015 Sep; 221():134-43. PubMed ID: 25701739
[TBL] [Abstract][Full Text] [Related]
19. Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
Chung BC; Picado-Leonard J; Haniu M; Bienkowski M; Hall PF; Shively JE; Miller WL
Proc Natl Acad Sci U S A; 1987 Jan; 84(2):407-11. PubMed ID: 3025870
[TBL] [Abstract][Full Text] [Related]
20. Androgen synthesis in adrenarche.
Miller WL
Rev Endocr Metab Disord; 2009 Mar; 10(1):3-17. PubMed ID: 18821018
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
