206 related articles for article (PubMed ID: 12460547)
1. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Leem JY; Saura CA; Pietrzik C; Christianson J; Wanamaker C; King LT; Veselits ML; Tomita T; Gasparini L; Iwatsubo T; Xu H; Green WN; Koo EH; Thinakaran G
Neurobiol Dis; 2002 Oct; 11(1):64-82. PubMed ID: 12460547
[TBL] [Abstract][Full Text] [Related]
2. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T; Ma G; Cai H; Price DL; Wong PC
J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
[TBL] [Abstract][Full Text] [Related]
3. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
J Biol Chem; 2000 Nov; 275(47):36794-802. PubMed ID: 10962005
[TBL] [Abstract][Full Text] [Related]
4. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
5. Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Vetrivel KS; Cheng H; Kim SH; Chen Y; Barnes NY; Parent AT; Sisodia SS; Thinakaran G
J Biol Chem; 2005 Jul; 280(27):25892-900. PubMed ID: 15886206
[TBL] [Abstract][Full Text] [Related]
6. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
[TBL] [Abstract][Full Text] [Related]
7. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
Liu Y; Zhang YW; Wang X; Zhang H; You X; Liao FF; Xu H
J Biol Chem; 2009 May; 284(18):12145-52. PubMed ID: 19276086
[TBL] [Abstract][Full Text] [Related]
8. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Xia W
Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
[TBL] [Abstract][Full Text] [Related]
9. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
Kim SH; Leem JY; Lah JJ; Slunt HH; Levey AI; Thinakaran G; Sisodia SS
J Biol Chem; 2001 Nov; 276(46):43343-50. PubMed ID: 11564743
[TBL] [Abstract][Full Text] [Related]
10. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
Pitsi D; Kienlen-Campard P; Octave JN
J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
[TBL] [Abstract][Full Text] [Related]
11. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.
Herreman A; Van Gassen G; Bentahir M; Nyabi O; Craessaerts K; Mueller U; Annaert W; De Strooper B
J Cell Sci; 2003 Mar; 116(Pt 6):1127-36. PubMed ID: 12584255
[TBL] [Abstract][Full Text] [Related]
12. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
13. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
Zhang Z; Nadeau P; Song W; Donoviel D; Yuan M; Bernstein A; Yankner BA
Nat Cell Biol; 2000 Jul; 2(7):463-5. PubMed ID: 10878814
[No Abstract] [Full Text] [Related]
14. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
15. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
[TBL] [Abstract][Full Text] [Related]
16. Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.
Palacino JJ; Berechid BE; Alexander P; Eckman C; Younkin S; Nye JS; Wolozin B
J Biol Chem; 2000 Jan; 275(1):215-22. PubMed ID: 10617607
[TBL] [Abstract][Full Text] [Related]
17. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
[TBL] [Abstract][Full Text] [Related]
18. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleó A; Berezovska O; Ramdya P; Fukumoto H; Raju S; Shah T; Hyman BT
J Biol Chem; 2003 Nov; 278(48):47370-5. PubMed ID: 12960155
[TBL] [Abstract][Full Text] [Related]
19. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
20. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
Berezovska O; Ramdya P; Skoch J; Wolfe MS; Bacskai BJ; Hyman BT
J Neurosci; 2003 Jun; 23(11):4560-6. PubMed ID: 12805296
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]