121 related articles for article (PubMed ID: 12464250)
1. Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase.
Xue L; Zgoda VG; Arison B; Correia MA
Arch Biochem Biophys; 2003 Jan; 409(1):113-26. PubMed ID: 12464250
[TBL] [Abstract][Full Text] [Related]
2. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.
Wang H; Dick R; Yin H; Licad-Coles E; Kroetz DL; Szklarz G; Harlow G; Halpert JR; Correia MA
Biochemistry; 1998 Sep; 37(36):12536-45. PubMed ID: 9730826
[TBL] [Abstract][Full Text] [Related]
3. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
Domanski TL; Schultz KM; Roussel F; Stevens JC; Halpert JR
J Pharmacol Exp Ther; 1999 Sep; 290(3):1141-7. PubMed ID: 10454488
[TBL] [Abstract][Full Text] [Related]
4. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
[TBL] [Abstract][Full Text] [Related]
5. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli.
Wang H; Strobel HW
Arch Biochem Biophys; 1997 Aug; 344(2):365-72. PubMed ID: 9264551
[TBL] [Abstract][Full Text] [Related]
6. Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
Domanski TL; He YA; Khan KK; Roussel F; Wang Q; Halpert JR
Biochemistry; 2001 Aug; 40(34):10150-60. PubMed ID: 11513592
[TBL] [Abstract][Full Text] [Related]
7. Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2.
Kawai M; Bandiera SM; Chang TK; Bellward GD
Biochem Pharmacol; 2000 May; 59(10):1277-87. PubMed ID: 10736428
[TBL] [Abstract][Full Text] [Related]
8. Amino acid 305 determines catalytic center accessibility in CYP3A4.
Fowler SM; Riley RJ; Pritchard MP; Sutcliffe MJ; Friedberg T; Wolf CR
Biochemistry; 2000 Apr; 39(15):4406-14. PubMed ID: 10757990
[TBL] [Abstract][Full Text] [Related]
9. Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.
Fraser DJ; He YQ; Harlow GR; Halpert JR
Mol Pharmacol; 1999 Feb; 55(2):241-7. PubMed ID: 9927614
[TBL] [Abstract][Full Text] [Related]
10. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
Spatzenegger M; Liu H; Wang Q; Debarber A; Koop DR; Halpert JR
J Pharmacol Exp Ther; 2003 Jan; 304(1):477-87. PubMed ID: 12490624
[TBL] [Abstract][Full Text] [Related]
11. The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.
Roussel F; Khan KK; Halpert JR
Arch Biochem Biophys; 2000 Feb; 374(2):269-78. PubMed ID: 10666307
[TBL] [Abstract][Full Text] [Related]
12. Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37).
Ourlin JC; Baader M; Fraser D; Halpert JR; Meyer UA
Arch Biochem Biophys; 2000 Jan; 373(2):375-84. PubMed ID: 10620362
[TBL] [Abstract][Full Text] [Related]
13. Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells.
Ohmori S; Nakasa H; Asanome K; Kurose Y; Ishii I; Hosokawa M; Kitada M
Biochim Biophys Acta; 1998 May; 1380(3):297-304. PubMed ID: 9555064
[TBL] [Abstract][Full Text] [Related]
14. Theoretical and experimental evaluation of a CYP106A2 low homology model and production of mutants with changed activity and selectivity of hydroxylation.
Lisurek M; Simgen B; Antes I; Bernhardt R
Chembiochem; 2008 Jun; 9(9):1439-49. PubMed ID: 18481342
[TBL] [Abstract][Full Text] [Related]
15. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
He YA; He YQ; Szklarz GD; Halpert JR
Biochemistry; 1997 Jul; 36(29):8831-9. PubMed ID: 9220969
[TBL] [Abstract][Full Text] [Related]
16. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
He YQ; Roussel F; Halpert JR
Arch Biochem Biophys; 2001 May; 389(2):264-70. PubMed ID: 11339816
[TBL] [Abstract][Full Text] [Related]
17. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.
Jäger W; Correia MA; Bornheim LM; Mahnke A; Hanstein WG; Xue L; Benet LZ
Drug Metab Dispos; 1999 Dec; 27(12):1505-11. PubMed ID: 10570034
[TBL] [Abstract][Full Text] [Related]
18. Helices F-G are important for the substrate specificities of CYP3A7.
Torimoto N; Ishii I; Toyama K; Hata M; Tanaka K; Shimomura H; Nakamura H; Ariyoshi N; Ohmori S; Kitada M
Drug Metab Dispos; 2007 Mar; 35(3):484-92. PubMed ID: 17178770
[TBL] [Abstract][Full Text] [Related]
19. Modulation of hepatic CYP2A1, CYP2C11, and CYP3A9 expression in adult rats by neonatal administration of tamoxifen.
Kawai M; Bandiera SM; Chang TK; Poulet FM; Vancutsem PM; Bellward GD
Drug Metab Dispos; 1999 Dec; 27(12):1392-8. PubMed ID: 10570019
[TBL] [Abstract][Full Text] [Related]
20. Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.
Matsubara T; Kim HJ; Miyata M; Shimada M; Nagata K; Yamazoe Y
J Pharmacol Exp Ther; 2004 Jun; 309(3):1282-90. PubMed ID: 15004215
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
