353 related articles for article (PubMed ID: 12476961)
1. Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.
Liu G; Trevillyan JM
Curr Opin Investig Drugs; 2002 Nov; 3(11):1608-16. PubMed ID: 12476961
[TBL] [Abstract][Full Text] [Related]
2. Protein tyrosine phosphatase 1B inhibitors for diabetes.
Johnson TO; Ermolieff J; Jirousek MR
Nat Rev Drug Discov; 2002 Sep; 1(9):696-709. PubMed ID: 12209150
[TBL] [Abstract][Full Text] [Related]
3. Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances.
Harley EA; Levens N
Curr Opin Investig Drugs; 2003 Oct; 4(10):1179-89. PubMed ID: 14649209
[TBL] [Abstract][Full Text] [Related]
4. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
Rao GS; Ramachandran MV; Bajaj JS
J Biomol Struct Dyn; 2006 Feb; 23(4):377-84. PubMed ID: 16363874
[TBL] [Abstract][Full Text] [Related]
5. Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes.
Tobin JF; Tam S
Curr Opin Drug Discov Devel; 2002 Jul; 5(4):500-12. PubMed ID: 12197308
[TBL] [Abstract][Full Text] [Related]
6. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.
Zhang S; Zhang ZY
Drug Discov Today; 2007 May; 12(9-10):373-81. PubMed ID: 17467573
[TBL] [Abstract][Full Text] [Related]
7. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B.
Wu Y; Ou-Yang JP; Wu K; Wang Y; Zhou YF; Wen CY
Acta Pharmacol Sin; 2005 Mar; 26(3):345-52. PubMed ID: 15715932
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.
Koren S; Fantus IG
Best Pract Res Clin Endocrinol Metab; 2007 Dec; 21(4):621-40. PubMed ID: 18054739
[TBL] [Abstract][Full Text] [Related]
9. Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control.
Popov D
Biochem Biophys Res Commun; 2011 Jul; 410(3):377-81. PubMed ID: 21683066
[TBL] [Abstract][Full Text] [Related]
10. Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.
Goldstein BJ
Curr Drug Targets Immune Endocr Metabol Disord; 2001 Nov; 1(3):265-75. PubMed ID: 12477292
[TBL] [Abstract][Full Text] [Related]
11. Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.
Stuible M; Zhao L; Aubry I; Schmidt-Arras D; Böhmer FD; Li CJ; Tremblay ML
Chembiochem; 2007 Jan; 8(2):179-86. PubMed ID: 17191286
[TBL] [Abstract][Full Text] [Related]
12. Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling.
Sun T; Wang Q; Yu Z; Zhang Y; Guo Y; Chen K; Shen X; Jiang H
Chembiochem; 2007 Jan; 8(2):187-93. PubMed ID: 17183521
[TBL] [Abstract][Full Text] [Related]
13. CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors.
Nair PC; Sobhia ME
J Mol Graph Model; 2007 Jul; 26(1):117-23. PubMed ID: 17140831
[TBL] [Abstract][Full Text] [Related]
14. Establishment of a cell-based drug screening model for identifying down-regulators of Protein Tyrosine Phosphatase 1B expression.
Lian JH; Guo L; Hu WR; Wu GL; Ji W; Gong BQ
Exp Clin Endocrinol Diabetes; 2007 Jan; 115(1):24-8. PubMed ID: 17286230
[TBL] [Abstract][Full Text] [Related]
15. Development of a robust scintillation proximity assay for protein tyrosine phosphatase 1B using the catalytically inactive (C215S) mutant.
Skorey KI; Kennedy BP; Friesen RW; Ramachandran C
Anal Biochem; 2001 Apr; 291(2):269-78. PubMed ID: 11401301
[TBL] [Abstract][Full Text] [Related]
16. [Does inhibition of tyrosine phosphatase 1B protect from obesity and type 2 diabetes?].
Ukkola O; Santaniemi M
Duodecim; 2002; 118(18):1857-62. PubMed ID: 12422667
[No Abstract] [Full Text] [Related]
17. Effects of small interference RNA against PTP1B and TCPTP on insulin signaling pathway in mouse liver: evidence for non-synergetic cooperation.
Xu J; Li L; Hong J; Huang W
Cell Biol Int; 2007 Jan; 31(1):88-91. PubMed ID: 17088077
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.
Szczepankiewicz BG; Liu G; Hajduk PJ; Abad-Zapatero C; Pei Z; Xin Z; Lubben TH; Trevillyan JM; Stashko MA; Ballaron SJ; Liang H; Huang F; Hutchins CW; Fesik SW; Jirousek MR
J Am Chem Soc; 2003 Apr; 125(14):4087-96. PubMed ID: 12670229
[TBL] [Abstract][Full Text] [Related]
19. Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.
Liu G
Curr Med Chem; 2003 Aug; 10(15):1407-21. PubMed ID: 12871138
[TBL] [Abstract][Full Text] [Related]
20. Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
Xu JQ; Shen Q; Li J; Hu LH
Bioorg Med Chem; 2010 Jun; 18(11):3934-9. PubMed ID: 20472439
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
