BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 12477350)

  • 1. Metal-dependent inhibition of HIV-1 integrase.
    Neamati N; Lin Z; Karki RG; Orr A; Cowansage K; Strumberg D; Pais GC; Voigt JH; Nicklaus MC; Winslow HE; Zhao H; Turpin JA; Yi J; Skalka AM; Burke TR; Pommier Y
    J Med Chem; 2002 Dec; 45(26):5661-70. PubMed ID: 12477350
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
    Kawasuji T; Fuji M; Yoshinaga T; Sato A; Fujiwara T; Kiyama R
    Bioorg Med Chem; 2006 Dec; 14(24):8420-9. PubMed ID: 17005407
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.
    Billamboz M; Bailly F; Lion C; Touati N; Vezin H; Calmels C; Andréola ML; Christ F; Debyser Z; Cotelle P
    J Med Chem; 2011 Mar; 54(6):1812-24. PubMed ID: 21366258
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.
    Zhao XZ; Semenova EA; Vu BC; Maddali K; Marchand C; Hughes SH; Pommier Y; Burke TR
    J Med Chem; 2008 Jan; 51(2):251-9. PubMed ID: 18095643
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
    Neamati N; Hong H; Owen JM; Sunder S; Winslow HE; Christensen JL; Zhao H; Burke TR; Milne GW; Pommier Y
    J Med Chem; 1998 Aug; 41(17):3202-9. PubMed ID: 9703465
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
    Fan X; Zhang FH; Al-Safi RI; Zeng LF; Shabaik Y; Debnath B; Sanchez TW; Odde S; Neamati N; Long YQ
    Bioorg Med Chem; 2011 Aug; 19(16):4935-52. PubMed ID: 21778063
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
    Mazumder A; Wang S; Neamati N; Nicklaus M; Sunder S; Chen J; Milne GW; Rice WG; Burke TR; Pommier Y
    J Med Chem; 1996 Jun; 39(13):2472-81. PubMed ID: 8691444
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family.
    Molteni V; Rhodes D; Rubins K; Hansen M; Bushman FD; Siegel JS
    J Med Chem; 2000 May; 43(10):2031-9. PubMed ID: 10821715
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.
    Long YQ; Jiang XH; Dayam R; Sanchez T; Shoemaker R; Sei S; Neamati N
    J Med Chem; 2004 May; 47(10):2561-73. PubMed ID: 15115398
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.
    Li BW; Zhang FH; Serrao E; Chen H; Sanchez TW; Yang LM; Neamati N; Zheng YT; Wang H; Long YQ
    Bioorg Med Chem; 2014 Jun; 22(12):3146-58. PubMed ID: 24794743
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase.
    Robinson WE; Cordeiro M; Abdel-Malek S; Jia Q; Chow SA; Reinecke MG; Mitchell WM
    Mol Pharmacol; 1996 Oct; 50(4):846-55. PubMed ID: 8863829
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.
    Rogolino D; Carcelli M; Compari C; De Luca L; Ferro S; Fisicaro E; Rispoli G; Neamati N; Debyser Z; Christ F; Chimirri A
    Eur J Med Chem; 2014 May; 78():425-30. PubMed ID: 24704615
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Naphthoxazepine inhibitors of HIV-1 integrase: synthesis and biological evaluation.
    Garofalo A; Grande F; Brizzi A; Aiello F; Dayam R; Neamati N
    ChemMedChem; 2008 Jun; 3(6):986-90. PubMed ID: 18383063
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors.
    Bacchi A; Carcelli M; Compari C; Fisicaro E; Pala N; Rispoli G; Rogolino D; Sanchez TW; Sechi M; Sinisi V; Neamati N
    J Med Chem; 2011 Dec; 54(24):8407-20. PubMed ID: 22066494
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors.
    Carcelli M; Rogolino D; Sechi M; Rispoli G; Fisicaro E; Compari C; Grandi N; Corona A; Tramontano E; Pannecouque C; Naesens L
    Eur J Med Chem; 2014 Aug; 83():594-600. PubMed ID: 24996145
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hydrazide-containing inhibitors of HIV-1 integrase.
    Zhao H; Neamati N; Sunder S; Hong H; Wang S; Milne GW; Pommier Y; Burke TR
    J Med Chem; 1997 Mar; 40(6):937-41. PubMed ID: 9083482
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
    Le G; Vandegraaff N; Rhodes DI; Jones ED; Coates JA; Thienthong N; Winfield LJ; Lu L; Li X; Yu C; Feng X; Deadman JJ
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5909-12. PubMed ID: 20727753
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
    Kehlenbeck S; Betz U; Birkmann A; Fast B; Göller AH; Henninger K; Lowinger T; Marrero D; Paessens A; Paulsen D; Pevzner V; Schohe-Loop R; Tsujishita H; Welker R; Kreuter J; Rübsamen-Waigmann H; Dittmer F
    J Virol; 2006 Jul; 80(14):6883-94. PubMed ID: 16809294
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.
    Nair V; Uchil V; Chi G; Dams I; Cox A; Seo B
    Nucleosides Nucleotides Nucleic Acids; 2007; 26(6-7):665-8. PubMed ID: 18066876
    [TBL] [Abstract][Full Text] [Related]  

  • 20. From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.
    Sechi M; Bacchi A; Carcelli M; Compari C; Duce E; Fisicaro E; Rogolino D; Gates P; Derudas M; Al-Mawsawi LQ; Neamati N
    J Med Chem; 2006 Jul; 49(14):4248-60. PubMed ID: 16821784
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.