BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 12481416)

  • 21. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Friedman HS; Dolan ME; Moschel RC; Pegg AE; Felker GM; Rich J; Bigner DD; Schold SC
    J Natl Cancer Inst; 1992 Dec; 84(24):1926-31. PubMed ID: 1334154
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
    Liu L; Lee K; Wasan E; Gerson SL
    Cancer Res; 1996 Apr; 56(8):1880-5. PubMed ID: 8620508
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
    Phillips WP; Gerson SL
    Cancer Chemother Pharmacol; 1999; 44(4):319-26. PubMed ID: 10447580
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
    Hansen RJ; Nagasubramanian R; Delaney SM; Cherian MM; Lin S; Kogan SC; Dolan ME
    J Pharmacol Exp Ther; 2005 Dec; 315(3):1247-55. PubMed ID: 16126841
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
    Gerson SL; Zborowska E; Norton K; Gordon NH; Willson JK
    Biochem Pharmacol; 1993 Jan; 45(2):483-91. PubMed ID: 8435098
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
    Bibby MC; Thompson MJ; Rafferty JA; Margison GP; McElhinney RS
    Br J Cancer; 1999 Mar; 79(9-10):1332-9. PubMed ID: 10188873
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Mitchell RB; Dolan ME
    Cancer Chemother Pharmacol; 1993; 32(1):59-63. PubMed ID: 8462125
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM; Reese JS; Koç ON; Lee K; Schupp JE; Gerson SL
    Cancer Res; 1997 Nov; 57(22):5093-9. PubMed ID: 9371508
    [TBL] [Abstract][Full Text] [Related]  

  • 29. New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance.
    Spiro T; Liu L; Gerson S
    Forum (Genova); 2000; 10(3):274-85. PubMed ID: 11007934
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Dolan ME; Pegg AE; Moschel RC; Grindey GB
    Biochem Pharmacol; 1993 Jul; 46(2):285-90. PubMed ID: 8347150
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Kokkinakis DM; Moschel RC; Pegg AE; Schold SC
    Cancer Chemother Pharmacol; 2000; 45(1):69-77. PubMed ID: 10647505
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Mitchell RB; Moschel RC; Dolan ME
    Cancer Res; 1992 Mar; 52(5):1171-5. PubMed ID: 1737376
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK; Dolan ME; Erickson LC
    Cancer Res; 1994 Aug; 54(16):4371-5. PubMed ID: 8044784
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
    Bacolod MD; Johnson SP; Pegg AE; Dolan ME; Moschel RC; Bullock NS; Fang Q; Colvin OM; Modrich P; Bigner DD; Friedman HS
    Mol Cancer Ther; 2004 Sep; 3(9):1127-35. PubMed ID: 15367707
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
    Pegg AE; Swenn K; Chae MY; Dolan ME; Moschel RC
    Biochem Pharmacol; 1995 Oct; 50(8):1141-8. PubMed ID: 7488227
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Meehan WJ; Pegg AE
    Biochem Pharmacol; 1999 Oct; 58(8):1279-85. PubMed ID: 10487529
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors.
    Friedman HS; Keir ST; Houghton PJ
    Cancer; 2003 May; 97(9 Suppl):2359-62. PubMed ID: 12712457
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Gerson SL; Phillips W; Kastan M; Dumenco LL; Donovan C
    Blood; 1996 Sep; 88(5):1649-55. PubMed ID: 8781420
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Activity of temozolomide in the treatment of central nervous system tumor xenografts.
    Friedman HS; Dolan ME; Pegg AE; Marcelli S; Keir S; Catino JJ; Bigner DD; Schold SC
    Cancer Res; 1995 Jul; 55(13):2853-7. PubMed ID: 7796412
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
    Quinn JA; Jiang SX; Reardon DA; Desjardins A; Vredenburgh JJ; Gururangan S; Sampson JH; McLendon RE; Herndon JE; Friedman HS
    Cancer; 2009 Jul; 115(13):2964-70. PubMed ID: 19402172
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.