These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 12482427)

  • 21. Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.
    Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L; Giocanti N; Sadri R; Favaudon V
    Bioorg Med Chem; 1999 Jul; 7(7):1281-93. PubMed ID: 10465404
    [TBL] [Abstract][Full Text] [Related]  

  • 22. X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research.
    Furet P
    Curr Med Chem Anticancer Agents; 2003 Jan; 3(1):15-23. PubMed ID: 12678911
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
    De Azevedo WF; Leclerc S; Meijer L; Havlicek L; Strnad M; Kim SH
    Eur J Biochem; 1997 Jan; 243(1-2):518-26. PubMed ID: 9030780
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching.
    Furet P; Meyer T; Mittl P; Fretz H
    J Comput Aided Mol Des; 2001 May; 15(5):489-95. PubMed ID: 11394741
    [TBL] [Abstract][Full Text] [Related]  

  • 25. 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors.
    Ducrot P; Legraverend M; Grierson DS
    J Med Chem; 2000 Nov; 43(22):4098-108. PubMed ID: 11063606
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The design and synthesis of purine inhibitors of CDK2. III.
    Shum PW; Peet NP; Weintraub PM; Le TB; Zhao Z; Barbone F; Cashman B; Tsay J; Dwyer S; Loos PC; Powers EA; Kropp K; Wright PS; Bitonti A; Dumont J; Borcherding DR
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1067-78. PubMed ID: 11562960
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
    Nugiel DA; Vidwans A; Etzkorn AM; Rossi KA; Benfield PA; Burton CR; Cox S; Doleniak D; Seitz SP
    J Med Chem; 2002 Nov; 45(24):5224-32. PubMed ID: 12431050
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.
    Yamamoto H; Monden T; Miyoshi H; Izawa H; Ikeda K; Tsujie M; Ohnishi T; Sekimoto M; Tomita N; Monden M
    Int J Oncol; 1998 Aug; 13(2):233-9. PubMed ID: 9664116
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2.
    Marchetti F; Sayle KL; Bentley J; Clegg W; Curtin NJ; Endicott JA; Golding BT; Griffin RJ; Haggerty K; Harrington RW; Mesguiche V; Newell DR; Noble ME; Parsons RJ; Pratt DJ; Wang LZ; Hardcastle IR
    Org Biomol Chem; 2007 May; 5(10):1577-85. PubMed ID: 17571187
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.
    Evers DL; Breitenbach JM; Borysko KZ; Townsend LB; Drach JC
    Antimicrob Agents Chemother; 2002 Aug; 46(8):2470-6. PubMed ID: 12121920
    [TBL] [Abstract][Full Text] [Related]  

  • 31. 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
    Wang S; Meades C; Wood G; Osnowski A; Anderson S; Yuill R; Thomas M; Mezna M; Jackson W; Midgley C; Griffiths G; Fleming I; Green S; McNae I; Wu SY; McInnes C; Zheleva D; Walkinshaw MD; Fischer PM
    J Med Chem; 2004 Mar; 47(7):1662-75. PubMed ID: 15027857
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
    Schoepfer J; Fretz H; Chaudhuri B; Muller L; Seeber E; Meijer L; Lozach O; Vangrevelinghe E; Furet P
    J Med Chem; 2002 Apr; 45(9):1741-7. PubMed ID: 11960485
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.
    Marchetti F; Cano C; Curtin NJ; Golding BT; Griffin RJ; Haggerty K; Newell DR; Parsons RJ; Payne SL; Wang LZ; Hardcastle IR
    Org Biomol Chem; 2010 May; 8(10):2397-407. PubMed ID: 20448898
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
    Markwalder JA; Arnone MR; Benfield PA; Boisclair M; Burton CR; Chang CH; Cox SS; Czerniak PM; Dean CL; Doleniak D; Grafstrom R; Harrison BA; Kaltenbach RF; Nugiel DA; Rossi KA; Sherk SR; Sisk LM; Stouten P; Trainor GL; Worland P; Seitz SP
    J Med Chem; 2004 Nov; 47(24):5894-911. PubMed ID: 15537345
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure-based design of potent CDK1 inhibitors derived from olomoucine.
    Furet P; Zimmermann J; Capraro HG; Meyer T; Imbach P
    J Comput Aided Mol Des; 2000 Jul; 14(5):403-9. PubMed ID: 10896313
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.
    Schultz C; Link A; Leost M; Zaharevitz DW; Gussio R; Sausville EA; Meijer L; Kunick C
    J Med Chem; 1999 Jul; 42(15):2909-19. PubMed ID: 10425100
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors.
    Toledo LM; Lydon NB
    Structure; 1997 Dec; 5(12):1551-6. PubMed ID: 9438871
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
    De Azevedo WF; Mueller-Dieckmann HJ; Schulze-Gahmen U; Worland PJ; Sausville E; Kim SH
    Proc Natl Acad Sci U S A; 1996 Apr; 93(7):2735-40. PubMed ID: 8610110
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
    Russo AA; Jeffrey PD; Patten AK; Massagué J; Pavletich NP
    Nature; 1996 Jul; 382(6589):325-31. PubMed ID: 8684460
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases.
    Vermeulen K; Strnad M; Krystof V; Havlícek L; Van der Aa A; Lenjou M; Nijs G; Rodrigus I; Stockman B; van Onckelen H; Van Bockstaele DR; Berneman ZN
    Leukemia; 2002 Mar; 16(3):299-305. PubMed ID: 11896531
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.