BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

286 related articles for article (PubMed ID: 12485949)

  • 1. Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity.
    Xie M; Yang D; Wu M; Xue B; Yan B
    Drug Metab Dispos; 2003 Jan; 31(1):21-7. PubMed ID: 12485949
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11).
    Potter PM; Pawlik CA; Morton CL; Naeve CW; Danks MK
    Cancer Res; 1998 Jun; 58(12):2646-51. PubMed ID: 9635592
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
    Sanghani SP; Quinney SK; Fredenburg TB; Davis WI; Murry DJ; Bosron WF
    Drug Metab Dispos; 2004 May; 32(5):505-11. PubMed ID: 15100172
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Enzyme-prodrug systems: carboxylesterase/CPT-11.
    Danks MK; Potter PM
    Methods Mol Med; 2004; 90():247-62. PubMed ID: 14657567
    [No Abstract]   [Full Text] [Related]  

  • 5. Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug.
    Senter PD; Beam KS; Mixan B; Wahl AF
    Bioconjug Chem; 2001; 12(6):1074-80. PubMed ID: 11716702
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.
    Danks MK; Morton CL; Krull EJ; Cheshire PJ; Richmond LB; Naeve CW; Pawlik CA; Houghton PJ; Potter PM
    Clin Cancer Res; 1999 Apr; 5(4):917-24. PubMed ID: 10213229
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.
    Wadkins RM; Morton CL; Weeks JK; Oliver L; Wierdl M; Danks MK; Potter PM
    Mol Pharmacol; 2001 Aug; 60(2):355-62. PubMed ID: 11455023
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proficient metabolism of irinotecan by a human intestinal carboxylesterase.
    Khanna R; Morton CL; Danks MK; Potter PM
    Cancer Res; 2000 Sep; 60(17):4725-8. PubMed ID: 10987276
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
    Humerickhouse R; Lohrbach K; Li L; Bosron WF; Dolan ME
    Cancer Res; 2000 Mar; 60(5):1189-92. PubMed ID: 10728672
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase.
    Guichard SM; Morton CL; Krull EJ; Stewart CF; Danks MK; Potter PM
    Clin Cancer Res; 1998 Dec; 4(12):3089-94. PubMed ID: 9865925
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines.
    Pavillard V; Agostini C; Richard S; Charasson V; Montaudon D; Robert J
    Cancer Chemother Pharmacol; 2002 Apr; 49(4):329-35. PubMed ID: 11914913
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11.
    Danks MK; Morton CL; Pawlik CA; Potter PM
    Cancer Res; 1998 Jan; 58(1):20-2. PubMed ID: 9426050
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into CPT-11 activation by mammalian carboxylesterases.
    Bencharit S; Morton CL; Howard-Williams EL; Danks MK; Potter PM; Redinbo MR
    Nat Struct Biol; 2002 May; 9(5):337-42. PubMed ID: 11967565
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.
    Hatfield MJ; Tsurkan L; Garrett M; Shaver TM; Hyatt JL; Edwards CC; Hicks LD; Potter PM
    Biochem Pharmacol; 2011 Jan; 81(1):24-31. PubMed ID: 20833148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs.
    Senter PD; Marquardt H; Thomas BA; Hammock BD; Frank IS; Svensson HP
    Cancer Res; 1996 Apr; 56(7):1471-4. PubMed ID: 8603386
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.
    Kojima A; Hackett NR; Ohwada A; Crystal RG
    J Clin Invest; 1998 Apr; 101(8):1789-96. PubMed ID: 9541511
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs.
    Xiao D; Shi D; Yang D; Barthel B; Koch TH; Yan B
    Biochem Pharmacol; 2013 Feb; 85(3):439-47. PubMed ID: 23228697
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
    Wu MH; Yan B; Humerickhouse R; Dolan ME
    Clin Cancer Res; 2002 Aug; 8(8):2696-700. PubMed ID: 12171903
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38.
    Charasson V; Bellott R; Meynard D; Longy M; Gorry P; Robert J
    Clin Pharmacol Ther; 2004 Dec; 76(6):528-35. PubMed ID: 15592324
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Modifications of human carboxylesterase for improved prodrug activation.
    Hatfield JM; Wierdl M; Wadkins RM; Potter PM
    Expert Opin Drug Metab Toxicol; 2008 Sep; 4(9):1153-65. PubMed ID: 18721110
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.