132 related articles for article (PubMed ID: 12485952)
41. The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein.
Lin HL; Hollenberg PF
J Pharmacol Exp Ther; 2007 Apr; 321(1):276-87. PubMed ID: 17251390
[TBL] [Abstract][Full Text] [Related]
42. The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.
Jang HH; Davydov DR; Lee GY; Yun CH; Halpert JR
Arch Biochem Biophys; 2014 Mar; 545():100-7. PubMed ID: 24445070
[TBL] [Abstract][Full Text] [Related]
43. Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
Blobaum AL; Kent UM; Alworth WL; Hollenberg PF
Chem Res Toxicol; 2002 Dec; 15(12):1561-71. PubMed ID: 12482238
[TBL] [Abstract][Full Text] [Related]
44. Inhibitory monoclonal antibody to human cytochrome P450 2B6.
Yang TJ; Krausz KW; Shou M; Yang SK; Buters JT; Gonzalez FJ; Gelboin HV
Biochem Pharmacol; 1998 May; 55(10):1633-40. PubMed ID: 9633999
[TBL] [Abstract][Full Text] [Related]
45. Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5.
Reed JR; Hollenberg PF
J Inorg Biochem; 2003 Jan; 93(3-4):152-60. PubMed ID: 12576277
[TBL] [Abstract][Full Text] [Related]
46. Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.
Bae SH; Kwon MJ; Choi EJ; Zheng YF; Yoon KD; Liu KH; Bae SK
Chem Biol Interact; 2013 Sep; 205(1):11-9. PubMed ID: 23777987
[TBL] [Abstract][Full Text] [Related]
47. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.
O'Donnell JP; Dalvie DK; Kalgutkar AS; Obach RS
Drug Metab Dispos; 2003 Nov; 31(11):1369-77. PubMed ID: 14570769
[TBL] [Abstract][Full Text] [Related]
48. Phencyclidine iminium ion. NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P-450.
Hoag MK; Trevor AJ; Kalir A; Castagnoli N
Drug Metab Dispos; 1987; 15(4):485-90. PubMed ID: 2888621
[TBL] [Abstract][Full Text] [Related]
49. Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based.
Richter T; Schwab M; Eichelbaum M; Zanger UM
Biochem Pharmacol; 2005 Feb; 69(3):517-24. PubMed ID: 15652242
[TBL] [Abstract][Full Text] [Related]
50. Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.
Shah MB; Wilderman PR; Pascual J; Zhang Q; Stout CD; Halpert JR
Biochemistry; 2012 Sep; 51(37):7225-38. PubMed ID: 22909231
[TBL] [Abstract][Full Text] [Related]
51. Mechanism-based inactivation of cytochrome P450 2B1 by N-benzyl-1-aminobenzotriazole.
Kent UM; Bend JR; Chamberlin BA; Gage DA; Hollenberg PF
Chem Res Toxicol; 1997 May; 10(5):600-8. PubMed ID: 9168259
[TBL] [Abstract][Full Text] [Related]
52. tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance.
Zhang H; Lin HL; Walker VJ; Hamdane D; Hollenberg PF
Mol Pharmacol; 2009 Nov; 76(5):1011-8. PubMed ID: 19720728
[TBL] [Abstract][Full Text] [Related]
53. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4.
Casabar RC; Wallace AD; Hodgson E; Rose RL
Drug Metab Dispos; 2006 Oct; 34(10):1779-85. PubMed ID: 16855053
[TBL] [Abstract][Full Text] [Related]
54. Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.
Richter T; Mürdter TE; Heinkele G; Pleiss J; Tatzel S; Schwab M; Eichelbaum M; Zanger UM
J Pharmacol Exp Ther; 2004 Jan; 308(1):189-97. PubMed ID: 14563790
[TBL] [Abstract][Full Text] [Related]
55. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism.
Rae JM; Soukhova NV; Flockhart DA; Desta Z
Drug Metab Dispos; 2002 May; 30(5):525-30. PubMed ID: 11950782
[TBL] [Abstract][Full Text] [Related]
56. Metabolism-dependent inactivation of liver microsomal enzymes by phencyclidine.
Hoag MK; Trevor AJ; Asscher Y; Weissman J; Castagnoli N
Drug Metab Dispos; 1984; 12(3):371-5. PubMed ID: 6145566
[TBL] [Abstract][Full Text] [Related]
57. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
Sridar C; Goosen TC; Kent UM; Williams JA; Hollenberg PF
Drug Metab Dispos; 2004 Jun; 32(6):587-94. PubMed ID: 15155549
[TBL] [Abstract][Full Text] [Related]
58. Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.
Kent UM; Lin HL; Noon KR; Harris DL; Hollenberg PF
J Pharmacol Exp Ther; 2006 Sep; 318(3):992-1005. PubMed ID: 16785317
[TBL] [Abstract][Full Text] [Related]
59. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
Heyn H; White RB; Stevens JC
Drug Metab Dispos; 1996 Sep; 24(9):948-54. PubMed ID: 8886603
[TBL] [Abstract][Full Text] [Related]
60. Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver.
Hanna IH; Reed JR; Guengerich FP; Hollenberg PF
Arch Biochem Biophys; 2000 Apr; 376(1):206-16. PubMed ID: 10729207
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
