165 related articles for article (PubMed ID: 12493839)
1. Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein.
Masip M; García-Ortega L; Olmo N; García-Mayoral MF; Pérez-Cañadillas JM; Bruix M; Oñaderra M; Martínez del Pozo A; Gavilanes JG
Protein Sci; 2003 Jan; 12(1):161-9. PubMed ID: 12493839
[TBL] [Abstract][Full Text] [Related]
2. Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin.
Masip M; Lacadena J; Mancheño JM; Oñaderra M; Martínez-Ruiz A; Martínez del Pozo A; Gavilanes JG
Eur J Biochem; 2001 Dec; 268(23):6190-6. PubMed ID: 11733014
[TBL] [Abstract][Full Text] [Related]
3. Deletion of the NH2-terminal beta-hairpin of the ribotoxin alpha-sarcin produces a nontoxic but active ribonuclease.
Garcia-Ortega L; Masip M; Mancheño JM; Oñaderra M; Lizarbe MA; García-Mayoral MF; Bruix M; Martínez del Pozo A; Gavilanes JG
J Biol Chem; 2002 May; 277(21):18632-9. PubMed ID: 11897788
[TBL] [Abstract][Full Text] [Related]
4. Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of alpha-sarcin.
Alvarez-García E; García-Ortega L; Verdún Y; Bruix M; Martínez del Pozo A; Gavilanes JG
Biol Chem; 2006 May; 387(5):535-41. PubMed ID: 16740124
[TBL] [Abstract][Full Text] [Related]
5. Dissecting structural and electrostatic interactions of charged groups in alpha-sarcin. An NMR study of some mutants involving the catalytic residues.
García-Mayoral MF; Pérez-Cañadillas JM; Santoro J; Ibarra-Molero B; Sanchez-Ruiz JM; Lacadena J; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
Biochemistry; 2003 Nov; 42(45):13122-33. PubMed ID: 14609322
[TBL] [Abstract][Full Text] [Related]
6. pH-Dependent conformational stability of the ribotoxin alpha-sarcin and four active site charge substitution variants.
García-Mayoral MF; del Pozo AM; Campos-Olivas R; Gavilanes JG; Santoro J; Rico M; Laurents DV; Bruix M
Biochemistry; 2006 Nov; 45(46):13705-18. PubMed ID: 17105190
[TBL] [Abstract][Full Text] [Related]
7. Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.
Siemer A; Masip M; Carreras N; García-Ortega L; Oñaderra M; Bruix M; Del Pozo AM; Gavilanes JG
Biol Chem; 2004 Dec; 385(12):1165-70. PubMed ID: 15653429
[TBL] [Abstract][Full Text] [Related]
8. Involvement of the amino-terminal beta-hairpin of the Aspergillus ribotoxins on the interaction with membranes and nonspecific ribonuclease activity.
García-Ortega L; Lacadena J; Mancheño JM; Oñaderra M; Kao R; Davies J; Olmo N; Pozo AM ; Gavilanes JG
Protein Sci; 2001 Aug; 10(8):1658-68. PubMed ID: 11468362
[TBL] [Abstract][Full Text] [Related]
9. Role of the basic character of alpha-sarcin's NH2-terminal beta-hairpin in ribosome recognition and phospholipid interaction.
Alvarez-García E; Martínez-del-Pozo A; Gavilanes JG
Arch Biochem Biophys; 2009 Jan; 481(1):37-44. PubMed ID: 18952045
[TBL] [Abstract][Full Text] [Related]
10. The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
Korennykh AV; Piccirilli JA; Correll CC
Nat Struct Mol Biol; 2006 May; 13(5):436-43. PubMed ID: 16604082
[TBL] [Abstract][Full Text] [Related]
11. Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins.
Herrero-Galán E; García-Ortega L; Lacadena J; Martínez-Del-Pozo A; Olmo N; Gavilanes JG; Oñaderra M
Biochimie; 2012 Feb; 94(2):427-33. PubMed ID: 21871524
[TBL] [Abstract][Full Text] [Related]
12. Cytotoxic mechanism of the ribotoxin alpha-sarcin. Induction of cell death via apoptosis.
Olmo N; Turnay J; González de Buitrago G; López de Silanes I; Gavilanes JG; Lizarbe MA
Eur J Biochem; 2001 Apr; 268(7):2113-23. PubMed ID: 11277935
[TBL] [Abstract][Full Text] [Related]
13. Minimized natural versions of fungal ribotoxins show improved active site plasticity.
Maestro-López M; Olombrada M; García-Ortega L; Serrano-González D; Lacadena J; Oñaderra M; Gavilanes JG; Martínez-Del-Pozo Á
Arch Biochem Biophys; 2017 Apr; 619():45-53. PubMed ID: 28283321
[TBL] [Abstract][Full Text] [Related]
14. The ribonucleolytic activity of the ribotoxin α-sarcin is not essential for in vitro protein biosynthesis inhibition.
Alvarez-García E; Diago-Navarro E; Herrero-Galán E; García-Ortega L; López-Villarejo J; Olmo N; Díaz-Orejas R; Gavilanes JG; Martínez-del-Pozo A
Biochim Biophys Acta; 2011 Oct; 1814(10):1377-82. PubMed ID: 21767671
[TBL] [Abstract][Full Text] [Related]
15. Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.
Pérez-Cañadilllas JM; García-Mayoral MF; Laurents DV; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
FEBS Lett; 2003 Jan; 534(1-3):197-201. PubMed ID: 12527386
[TBL] [Abstract][Full Text] [Related]
16. The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin.
Herrero-Galán E; Lacadena J; Martínez del Pozo A; Boucias DG; Olmo N; Oñaderra M; Gavilanes JG
Proteins; 2008 Jul; 72(1):217-28. PubMed ID: 18214983
[TBL] [Abstract][Full Text] [Related]
17. Secretion of recombinant pro- and mature fungal alpha-sarcin ribotoxin by the methylotrophic yeast Pichia pastoris: the Lys-Arg motif is required for maturation.
Martínez-Ruiz A; Martínez del Pozo A; Lacadena J; Mancheño JM; Oñaderra M; López-otín C; Gavilanes JG
Protein Expr Purif; 1998 Apr; 12(3):315-22. PubMed ID: 9535698
[TBL] [Abstract][Full Text] [Related]
18. Involvement of loops 2 and 3 of α-sarcin on its ribotoxic activity.
Castaño-Rodríguez C; Olombrada M; Partida-Hanon A; Lacadena J; Oñaderra M; Gavilanes JG; García-Ortega L; Martínez-Del-Pozo Á
Toxicon; 2015 Mar; 96():1-9. PubMed ID: 25598497
[TBL] [Abstract][Full Text] [Related]
19. Modeling the highly specific ribotoxin recognition of ribosomes.
García-Mayoral F; García-Ortega L; Alvarez-García E; Bruix M; Gavilanes JG; del Pozo AM
FEBS Lett; 2005 Dec; 579(30):6859-64. PubMed ID: 16337202
[TBL] [Abstract][Full Text] [Related]
20. Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin.
Lacadena J; Martínez del Pozo A; Martínez-Ruiz A; Pérez-Cañadillas JM; Bruix M; Mancheño JM; Oñaderra M; Gavilanes JG
Proteins; 1999 Nov; 37(3):474-84. PubMed ID: 10591106
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]