188 related articles for article (PubMed ID: 12494404)
1. Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-HT6 receptor.
Purohit A; Herrick-Davis K; Teitler M
Synapse; 2003 Mar; 47(3):218-24. PubMed ID: 12494404
[TBL] [Abstract][Full Text] [Related]
2. Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.
Egan CT; Herrick-Davis K; Teitler M
J Pharmacol Exp Ther; 1998 Jul; 286(1):85-90. PubMed ID: 9655845
[TBL] [Abstract][Full Text] [Related]
3. Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: positioning of the third intracellular loop distal junction and its G(o)alpha protein interactions.
Pauwels PJ; Gouble A; Wurch T
Biochem J; 1999 Oct; 343 Pt 2(Pt 2):435-42. PubMed ID: 10510311
[TBL] [Abstract][Full Text] [Related]
4. Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations.
Brys R; Josson K; Castelli MP; Jurzak M; Lijnen P; Gommeren W; Leysen JE
Mol Pharmacol; 2000 Jun; 57(6):1132-41. PubMed ID: 10825383
[TBL] [Abstract][Full Text] [Related]
5. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
Monsma FJ; Shen Y; Ward RP; Hamblin MW; Sibley DR
Mol Pharmacol; 1993 Mar; 43(3):320-7. PubMed ID: 7680751
[TBL] [Abstract][Full Text] [Related]
6. Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors.
Xie J; Dernovici S; Ribeiro P
J Neurochem; 2005 Jan; 92(2):375-87. PubMed ID: 15663485
[TBL] [Abstract][Full Text] [Related]
7. Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Herrick-Davis K; Grinde E; Teitler M
J Pharmacol Exp Ther; 2000 Oct; 295(1):226-32. PubMed ID: 10991983
[TBL] [Abstract][Full Text] [Related]
8. Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus.
Almaula N; Ebersole BJ; Ballesteros JA; Weinstein H; Sealfon SC
Mol Pharmacol; 1996 Jul; 50(1):34-42. PubMed ID: 8700116
[TBL] [Abstract][Full Text] [Related]
9. Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
Egan C; Grinde E; Dupre A; Roth BL; Hake M; Teitler M; Herrick-Davis K
Synapse; 2000 Feb; 35(2):144-50. PubMed ID: 10611640
[TBL] [Abstract][Full Text] [Related]
10. Functional significance of the BBXXB motif reversed present in the cytoplasmic domains of the human follicle-stimulating hormone receptor.
Timossi C; Ortiz-Elizondo C; Pineda DB; Dias JA; Conn PM; Ulloa-Aguirre A
Mol Cell Endocrinol; 2004 Aug; 223(1-2):17-26. PubMed ID: 15279907
[TBL] [Abstract][Full Text] [Related]
11. Molecular analysis of the interaction between the intracellular loops of the human serotonin receptor type 6 (5-HT6) and the alpha subunit of GS protein.
Kang H; Lee WK; Choi YH; Vukoti KM; Bang WG; Yu YG
Biochem Biophys Res Commun; 2005 Apr; 329(2):684-92. PubMed ID: 15737640
[TBL] [Abstract][Full Text] [Related]
12. Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.
Purohit A; Smith C; Herrick-Davis K; Teitler M
Psychopharmacology (Berl); 2005 May; 179(2):461-9. PubMed ID: 15821958
[TBL] [Abstract][Full Text] [Related]
13. Mutagenesis of the human 5-HT1B receptor: differences from the closely related 5-HT1A receptor and the role of residue F331 in signal transduction.
Grånäs C; Nordvall G; Larhammar D
J Recept Signal Transduct Res; 1998; 18(4-6):225-41. PubMed ID: 9879059
[TBL] [Abstract][Full Text] [Related]
14. Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization.
Gray JA; Compton-Toth BA; Roth BL
Biochemistry; 2003 Sep; 42(36):10853-62. PubMed ID: 12962510
[TBL] [Abstract][Full Text] [Related]
15. Mutant 5-hydroxytryptamine 1A receptor D116A is a receptor activated solely by synthetic ligands with a rich pharmacology.
Cussac D; Palmier C; Finana F; De Vries L; Tardif S; Léger C; Bernois S; Heusler P
J Pharmacol Exp Ther; 2009 Oct; 331(1):222-33. PubMed ID: 19605522
[TBL] [Abstract][Full Text] [Related]
16. Whole spectrum analysis of ligand efficacy at constitutively active human wild-type and S267K 5-HT6 receptors in HEK-293F cells.
Romero G; Pujol M; Pérez P; Buschmann H; Pauwels PJ
J Pharmacol Toxicol Methods; 2007; 55(2):144-50. PubMed ID: 16769227
[TBL] [Abstract][Full Text] [Related]
17. Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor.
Brüss M; Kiel S; Bönisch H; Kostanian A; Göthert M
Neurochem Int; 2005 Aug; 47(3):196-203. PubMed ID: 15896881
[TBL] [Abstract][Full Text] [Related]
18. Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.
de la Fuente T; Martín-Fontecha M; Sallander J; Benhamú B; Campillo M; Medina RA; Pellissier LP; Claeysen S; Dumuis A; Pardo L; López-Rodríguez ML
J Med Chem; 2010 Feb; 53(3):1357-69. PubMed ID: 20078106
[TBL] [Abstract][Full Text] [Related]
19. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.
Kristiansen K; Kroeze WK; Willins DL; Gelber EI; Savage JE; Glennon RA; Roth BL
J Pharmacol Exp Ther; 2000 Jun; 293(3):735-46. PubMed ID: 10869371
[TBL] [Abstract][Full Text] [Related]
20. Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways.
Romero G; Sánchez E; Pujol M; Pérez P; Codony X; Holenz J; Buschmann H; Pauwels PJ
Br J Pharmacol; 2006 Aug; 148(8):1133-43. PubMed ID: 16865095
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
