149 related articles for article (PubMed ID: 12496269)
1. Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process.
Brufatto N; Nesheim ME
J Biol Chem; 2003 Feb; 278(9):6755-64. PubMed ID: 12496269
[TBL] [Abstract][Full Text] [Related]
2. A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.
Bukys MA; Kim PY; Nesheim ME; Kalafatis M
J Biol Chem; 2006 Dec; 281(51):39194-204. PubMed ID: 17020886
[TBL] [Abstract][Full Text] [Related]
3. Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa.
Bukys MA; Blum MA; Kim PY; Brufatto N; Nesheim ME; Kalafatis M
J Biol Chem; 2005 Jul; 280(29):27393-401. PubMed ID: 15897196
[TBL] [Abstract][Full Text] [Related]
4. Characterization of a stable form of human meizothrombin derived from recombinant prothrombin (R155A, R271A, and R284A).
Côté HC; Stevens WK; Bajzar L; Banfield DK; Nesheim ME; MacGillivray RT
J Biol Chem; 1994 Apr; 269(15):11374-80. PubMed ID: 8157669
[TBL] [Abstract][Full Text] [Related]
5. The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase.
Bukys MA; Orban T; Kim PY; Nesheim ME; Kalafatis M
Thromb Haemost; 2008 Mar; 99(3):511-22. PubMed ID: 18327399
[TBL] [Abstract][Full Text] [Related]
6. Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.
Hirbawi J; Bukys MA; Barhoover MA; Erdogan E; Kalafatis M
Biochemistry; 2008 Jul; 47(30):7963-74. PubMed ID: 18590276
[TBL] [Abstract][Full Text] [Related]
7. Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin.
Orcutt SJ; Krishnaswamy S
J Biol Chem; 2004 Dec; 279(52):54927-36. PubMed ID: 15494418
[TBL] [Abstract][Full Text] [Related]
8. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex.
Yegneswaran S; Mesters RM; Fernández JA; Griffin JH
J Biol Chem; 2004 Nov; 279(47):49019-25. PubMed ID: 15331602
[TBL] [Abstract][Full Text] [Related]
9. Further evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavages.
Kim PY; Nesheim ME
J Biol Chem; 2007 Nov; 282(45):32568-81. PubMed ID: 17726029
[TBL] [Abstract][Full Text] [Related]
10. The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.
Bukys MA; Orban T; Kim PY; Beck DO; Nesheim ME; Kalafatis M
J Biol Chem; 2006 Jul; 281(27):18569-80. PubMed ID: 16624813
[TBL] [Abstract][Full Text] [Related]
11. Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.
Krishnaswamy S; Church WR; Nesheim ME; Mann KG
J Biol Chem; 1987 Mar; 262(7):3291-9. PubMed ID: 3818642
[TBL] [Abstract][Full Text] [Related]
12. Calcium ion modulation of meizothrombin autolysis at Arg55-Asp56 and catalytic activity.
Stevens WK; Côté HF; MacGillivray RT; Nesheim ME
J Biol Chem; 1996 Apr; 271(14):8062-7. PubMed ID: 8626490
[TBL] [Abstract][Full Text] [Related]
13. The factor V activation paradox.
Orfeo T; Brufatto N; Nesheim ME; Xu H; Butenas S; Mann KG
J Biol Chem; 2004 May; 279(19):19580-91. PubMed ID: 14982929
[TBL] [Abstract][Full Text] [Related]
14. Contribution of amino acid region 659-663 of Factor Va heavy chain to the activity of factor Xa within prothrombinase .
Hirbawi J; Vaughn JL; Bukys MA; Vos HL; Kalafatis M
Biochemistry; 2010 Oct; 49(39):8520-34. PubMed ID: 20722419
[TBL] [Abstract][Full Text] [Related]
15. The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis.
Walker RK; Krishnaswamy S
J Biol Chem; 1994 Nov; 269(44):27441-50. PubMed ID: 7961657
[TBL] [Abstract][Full Text] [Related]
16. The use of prothrombin(S525C) labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation.
Brufatto N; Nesheim ME
J Biol Chem; 2001 May; 276(21):17663-71. PubMed ID: 11278943
[TBL] [Abstract][Full Text] [Related]
17. Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites.
Boskovic DS; Krishnaswamy S
J Biol Chem; 2000 Dec; 275(49):38561-70. PubMed ID: 10984491
[TBL] [Abstract][Full Text] [Related]
18. The second kringle domain of prothrombin promotes factor Va-mediated prothrombin activation by prothrombinase.
Kotkow KJ; Deitcher SR; Furie B; Furie BC
J Biol Chem; 1995 Mar; 270(9):4551-7. PubMed ID: 7876224
[TBL] [Abstract][Full Text] [Related]
19. Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid.
Boskovic DS; Giles AR; Nesheim ME
J Biol Chem; 1990 Jun; 265(18):10497-505. PubMed ID: 2355010
[TBL] [Abstract][Full Text] [Related]
20. Proexosite-1-dependent recognition and activation of prothrombin by taipan venom.
Chen L; Rezaie AR
J Biol Chem; 2004 Apr; 279(17):17869-74. PubMed ID: 14769787
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]