168 related articles for article (PubMed ID: 12496270)
1. A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking the calcium-dependent transforming growth factor-beta 1 signaling cascade.
Kobayashi H; Suzuki M; Tanaka Y; Kanayama N; Terao T
J Biol Chem; 2003 Mar; 278(10):7790-9. PubMed ID: 12496270
[TBL] [Abstract][Full Text] [Related]
2. Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells.
Hirashima Y; Kobayashi H; Suzuki M; Tanaka Y; Kanayama N; Terao T
J Biol Chem; 2003 Jul; 278(29):26793-802. PubMed ID: 12743121
[TBL] [Abstract][Full Text] [Related]
3. A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.
Kobayashi H; Suzuki M; Kanayama N; Terao T
Clin Exp Metastasis; 2004; 21(2):159-66. PubMed ID: 15168733
[TBL] [Abstract][Full Text] [Related]
4. Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.
Kobayashi H; Suzuki M; Kanayama N; Terao T
J Biol Chem; 2004 Feb; 279(8):6371-9. PubMed ID: 14597629
[TBL] [Abstract][Full Text] [Related]
5. Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated through inhibition of Src-dependent signaling pathways.
Inagaki K; Kobayashi H; Yoshida R; Kanada Y; Fukuda Y; Yagyu T; Kondo T; Kurita N; Kitanaka T; Yamada Y; Sakamoto Y; Suzuki M; Kanayama N; Terao T
J Biol Chem; 2005 Sep; 280(36):31428-37. PubMed ID: 16002410
[TBL] [Abstract][Full Text] [Related]
6. A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings.
Yagyu T; Kobayashi H; Wakahara K; Matsuzaki H; Kondo T; Kurita N; Sekino H; Inagaki K; Suzuki M; Kanayama N; Terao T
FEBS Lett; 2004 Oct; 576(3):408-16. PubMed ID: 15498571
[TBL] [Abstract][Full Text] [Related]
7. Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.
Tanaka Y; Kobayashi H; Suzuki M; Hirashima Y; Kanayama N; Terao T
Int J Cancer; 2004 Apr; 109(3):336-47. PubMed ID: 14961570
[TBL] [Abstract][Full Text] [Related]
8. Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.
Wakahara K; Kobayashi H; Yagyu T; Matsuzaki H; Kondo T; Kurita N; Sekino H; Inagaki K; Suzuki M; Kanayama N; Terao T
J Cell Biochem; 2004 Oct; 93(3):437-53. PubMed ID: 15372629
[TBL] [Abstract][Full Text] [Related]
9. Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin.
Suzuki M; Kobayashi H; Tanaka Y; Hirashima Y; Kanayama N; Takei Y; Saga Y; Suzuki M; Itoh H; Terao T
Int J Cancer; 2003 Apr; 104(3):289-302. PubMed ID: 12569552
[TBL] [Abstract][Full Text] [Related]
10. Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells.
Tanaka Y; Kobayashi H; Suzuki M; Kanayama N; Terao T
J Biol Chem; 2004 Mar; 279(10):8567-76. PubMed ID: 14676209
[TBL] [Abstract][Full Text] [Related]
11. Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.
Kobayashi H; Suzuki M; Kanayama N; Nishida T; Takigawa M; Terao T
Eur J Biochem; 2002 Aug; 269(16):3945-57. PubMed ID: 12180971
[TBL] [Abstract][Full Text] [Related]
12. Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
Albo D; Berger DH; Vogel J; Tuszynski GP
J Gastrointest Surg; 1999; 3(4):411-7. PubMed ID: 10482694
[TBL] [Abstract][Full Text] [Related]
13. Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.
Takei Y; Mizukami H; Saga Y; Kobayashi H; Suzuki M; Matsushita T; Ozawa K; Suzuki M
Int J Cancer; 2005 Jan; 113(1):54-8. PubMed ID: 15386422
[TBL] [Abstract][Full Text] [Related]
14. Bikunin target genes in ovarian cancer cells identified by microarray analysis.
Suzuki M; Kobayashi H; Tanaka Y; Hirashima Y; Kanayama N; Takei Y; Saga Y; Suzuki M; Itoh H; Terao T
J Biol Chem; 2003 Apr; 278(17):14640-6. PubMed ID: 12571229
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase.
Suzuki M; Kobayashi H; Kanayama N; Saga Y; Suzuki M; Lin CY; Dickson RB; Terao T
J Biol Chem; 2004 Apr; 279(15):14899-908. PubMed ID: 14747469
[TBL] [Abstract][Full Text] [Related]
16. Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cells.
Arnoletti JP; Albo D; Granick MS; Solomon MP; Castiglioni A; Rothman VL; Tuszynski GP
Cancer; 1995 Sep; 76(6):998-1005. PubMed ID: 8625226
[TBL] [Abstract][Full Text] [Related]
17. Transforming growth factor-beta1 inhibits tumor growth in a mouse melanoma model by down-regulating the plasminogen activation system.
Ramont L; Pasco S; Hornebeck W; Maquart FX; Monboisse JC
Exp Cell Res; 2003 Nov; 291(1):1-10. PubMed ID: 14597403
[TBL] [Abstract][Full Text] [Related]
18. Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta.
Shiou SR; Datta PK; Dhawan P; Law BK; Yingling JM; Dixon DA; Beauchamp RD
J Biol Chem; 2006 Nov; 281(45):33971-81. PubMed ID: 16959768
[TBL] [Abstract][Full Text] [Related]
19. Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer.
Kobayashi H; Yagyu T; Inagaki K; Kondo T; Suzuki M; Kanayama N; Terao T
Cancer; 2004 Feb; 100(4):869-77. PubMed ID: 14770446
[TBL] [Abstract][Full Text] [Related]
20. Osteoblast-derived TGF-beta1 modulates matrix degrading protease expression and activity in prostate cancer cells.
Festuccia C; Angelucci A; Gravina GL; Villanova I; Teti A; Albini A; Bologna M
Int J Cancer; 2000 Feb; 85(3):407-15. PubMed ID: 10652434
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]