BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 12501179)

  • 1. Structural insights into the avian AICAR transformylase mechanism.
    Wolan DW; Greasley SE; Beardsley GP; Wilson IA
    Biochemistry; 2002 Dec; 41(52):15505-13. PubMed ID: 12501179
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
    Wolan DW; Cheong CG; Greasley SE; Wilson IA
    Biochemistry; 2004 Feb; 43(5):1171-83. PubMed ID: 14756553
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
    Wolan DW; Greasley SE; Wall MJ; Benkovic SJ; Wilson IA
    Biochemistry; 2003 Sep; 42(37):10904-14. PubMed ID: 12974624
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
    Greasley SE; Horton P; Ramcharan J; Beardsley GP; Benkovic SJ; Wilson IA
    Nat Struct Biol; 2001 May; 8(5):402-6. PubMed ID: 11323713
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis.
    Wall M; Shim JH; Benkovic SJ
    Biochemistry; 2000 Sep; 39(37):11303-11. PubMed ID: 10985775
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
    Cheong CG; Wolan DW; Greasley SE; Horton PA; Beardsley GP; Wilson IA
    J Biol Chem; 2004 Apr; 279(17):18034-45. PubMed ID: 14966129
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.
    Verma P; Kar B; Varshney R; Roy P; Sharma AK
    FEBS J; 2017 Dec; 284(24):4233-4261. PubMed ID: 29063699
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus.
    Lonare S; Rode S; Verma P; Verma S; Kaur H; Alam MS; Wangmo P; Kumar P; Roy P; Sharma AK
    Biochim Biophys Acta Proteins Proteom; 2024 Jul; 1872(4):141015. PubMed ID: 38615986
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase.
    Vergis JM; Beardsley GP
    Biochemistry; 2004 Feb; 43(5):1184-92. PubMed ID: 14756554
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.
    Vergis JM; Bulock KG; Fleming KG; Beardsley GP
    J Biol Chem; 2001 Mar; 276(11):7727-33. PubMed ID: 11096114
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution.
    Axelrod HL; McMullan D; Krishna SS; Miller MD; Elsliger MA; Abdubek P; Ambing E; Astakhova T; Carlton D; Chiu HJ; Clayton T; Duan L; Feuerhelm J; Grzechnik SK; Hale J; Han GW; Haugen J; Jaroszewski L; Jin KK; Klock HE; Knuth MW; Koesema E; Morse AT; Nigoghossian E; Okach L; Oommachen S; Paulsen J; Quijano K; Reyes R; Rife CL; van den Bedem H; Weekes D; White A; Wolf G; Xu Q; Hodgson KO; Wooley J; Deacon AM; Godzik A; Lesley SA; Wilson IA
    Proteins; 2008 May; 71(2):1042-9. PubMed ID: 18260100
    [No Abstract]   [Full Text] [Related]  

  • 12. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.
    Le Nours J; Bulloch EM; Zhang Z; Greenwood DR; Middleditch MJ; Dickson JM; Baker EN
    J Biol Chem; 2011 Nov; 286(47):40706-16. PubMed ID: 21956117
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations.
    Shim JH; Wall M; Benkovic SJ; Díaz N; Suárez D; Merz KM
    J Am Chem Soc; 2001 May; 123(20):4687-96. PubMed ID: 11457277
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relationship between the catalytic sites of human bifunctional IMP synthase.
    Szabados E; Christopherson RI
    Int J Biochem Cell Biol; 1998 Aug; 30(8):933-42. PubMed ID: 9744084
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.
    Reyes VM; Greasley SE; Stura EA; Beardsley GP; Wilson IA
    Acta Crystallogr D Biol Crystallogr; 2000 Aug; 56(Pt 8):1051-4. PubMed ID: 10944351
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
    Xu L; Li C; Olson AJ; Wilson IA
    J Biol Chem; 2004 Nov; 279(48):50555-65. PubMed ID: 15355974
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
    Zhang Y; Desharnais J; Greasley SE; Beardsley GP; Boger DL; Wilson IA
    Biochemistry; 2002 Dec; 41(48):14206-15. PubMed ID: 12450384
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
    Bulock KG; Beardsley GP; Anderson KS
    J Biol Chem; 2002 Jun; 277(25):22168-74. PubMed ID: 11948179
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH; Labroli MA; Hedrick MP; Jin Q; Desharnais J; Baker SJ; Gooljarsingh LT; Ramcharan J; Tavassoli A; Zhang Y; Wilson IA; Beardsley GP; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2002 Aug; 10(8):2739-49. PubMed ID: 12057663
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
    Li C; Xu L; Wolan DW; Wilson IA; Olson AJ
    J Med Chem; 2004 Dec; 47(27):6681-90. PubMed ID: 15615517
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.