These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 12501201)

  • 1. The catalytic power of ketosteroid isomerase investigated by computer simulation.
    Feierberg I; Aqvist J
    Biochemistry; 2002 Dec; 41(52):15728-35. PubMed ID: 12501201
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pseudoreversion of the catalytic activity of Y14F by the additional substitution(s) of tyrosine with phenylalanine in the hydrogen bond network of delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
    Choi G; Ha NC; Kim MS; Hong BH; Oh BH; Choi KY
    Biochemistry; 2001 Jun; 40(23):6828-35. PubMed ID: 11389596
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Water in the active site of ketosteroid isomerase.
    Hanoian P; Hammes-Schiffer S
    Biochemistry; 2011 Aug; 50(31):6689-700. PubMed ID: 21710970
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase.
    Jang DS; Choi G; Cha HJ; Shin S; Hong BH; Lee HJ; Lee HC; Choi KY
    Mol Cells; 2015 May; 38(5):409-15. PubMed ID: 25947291
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High-resolution crystal structures of delta5-3-ketosteroid isomerase with and without a reaction intermediate analogue.
    Kim SW; Cha SS; Cho HS; Kim JS; Ha NC; Cho MJ; Joo S; Kim KK; Choi KY; Oh BH
    Biochemistry; 1997 Nov; 36(46):14030-6. PubMed ID: 9369474
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Contribution of the hydrogen-bond network involving a tyrosine triad in the active site to the structure and function of a highly proficient ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim DH; Jang DS; Nam GH; Choi G; Kim JS; Ha NC; Kim MS; Oh BH; Choi KY
    Biochemistry; 2000 Apr; 39(16):4581-9. PubMed ID: 10769113
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural double-mutant cycle analysis of a hydrogen bond network in ketosteroid isomerase from Pseudomonas putida biotype B.
    Jang DS; Cha HJ; Cha SS; Hong BH; Ha NC; Lee JY; Oh BH; Lee HS; Choi KY
    Biochem J; 2004 Sep; 382(Pt 3):967-73. PubMed ID: 15228388
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Computational study of ketosteroid isomerase: insights from molecular dynamics simulation of enzyme bound substrate and intermediate.
    Mazumder D; Kahn K; Bruice TC
    J Am Chem Soc; 2003 Jun; 125(25):7553-61. PubMed ID: 12812495
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.
    Schwans JP; Kraut DA; Herschlag D
    Proc Natl Acad Sci U S A; 2009 Aug; 106(34):14271-5. PubMed ID: 19706511
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutational analysis of the three cysteines and active-site aspartic acid 103 of ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim SW; Joo S; Choi G; Cho HS; Oh BH; Choi KY
    J Bacteriol; 1997 Dec; 179(24):7742-7. PubMed ID: 9401033
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamics and quantum chemical studies on the catalytic mechanism of Delta5-3-ketosteroid isomerase: the catalytic diad versus the cooperative hydrogen bond mechanism.
    Park H; Merz KM
    J Am Chem Soc; 2003 Jan; 125(4):901-11. PubMed ID: 12537487
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulations.
    Chakravorty DK; Hammes-Schiffer S
    J Am Chem Soc; 2010 Jun; 132(21):7549-55. PubMed ID: 20450180
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure and enzyme mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas testosteroni.
    Cho HS; Choi G; Choi KY; Oh BH
    Biochemistry; 1998 Jun; 37(23):8325-30. PubMed ID: 9622484
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Contribution of conserved amino acids at the dimeric interface to the conformational stability and the structural integrity of the active site in ketosteroid isomerase from Pseudomonas putida biotype B.
    Nam GH; Kim DH; Ha NC; Jang DS; Yun YS; Hong BH; Oh BH; Choi KY
    J Biochem; 2003 Jul; 134(1):101-10. PubMed ID: 12944376
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly in the catalytic mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
    Choi G; Ha NC; Kim SW; Kim DH; Park S; Oh BH; Choi KY
    Biochemistry; 2000 Feb; 39(5):903-9. PubMed ID: 10653633
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Proton affinity of the oxyanion hole in the active site of ketosteroid isomerase.
    Childs W; Boxer SG
    Biochemistry; 2010 Mar; 49(12):2725-31. PubMed ID: 20143849
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The conserved cis-Pro39 residue plays a crucial role in the proper positioning of the catalytic base Asp38 in ketosteroid isomerase from Comamonas testosteroni.
    Nam GH; Cha SS; Yun YS; Oh YH; Hong BH; Lee HS; Choi KY
    Biochem J; 2003 Oct; 375(Pt 2):297-305. PubMed ID: 12852789
    [TBL] [Abstract][Full Text] [Related]  

  • 18. QM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis.
    van der Kamp MW; Chaudret R; Mulholland AJ
    FEBS J; 2013 Jul; 280(13):3120-31. PubMed ID: 23356661
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of conserved Met112 residue in the catalytic activity and stability of ketosteroid isomerase.
    Cha HJ; Jang do S; Jeong JH; Hong BH; Yun YS; Shin EJ; Choi KY
    Biochim Biophys Acta; 2016 Oct; 1864(10):1322-7. PubMed ID: 27375051
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Maintenance of alpha-helical structures by phenyl rings in the active-site tyrosine triad contributes to catalysis and stability of ketosteroid isomerase from Pseudomonas putida biotype B.
    Nam GH; Jang DS; Cha SS; Lee TH; Kim DH; Hong BH; Yun YS; Oh BH; Choi KY
    Biochemistry; 2001 Nov; 40(45):13529-37. PubMed ID: 11695900
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.