413 related articles for article (PubMed ID: 12509506)
1. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
Goodwin B; Gauthier KC; Umetani M; Watson MA; Lochansky MI; Collins JL; Leitersdorf E; Mangelsdorf DJ; Kliewer SA; Repa JJ
Proc Natl Acad Sci U S A; 2003 Jan; 100(1):223-8. PubMed ID: 12509506
[TBL] [Abstract][Full Text] [Related]
2. Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.
Honda A; Salen G; Matsuzaki Y; Batta AK; Xu G; Leitersdorf E; Tint GS; Erickson SK; Tanaka N; Shefer S
J Biol Chem; 2001 Sep; 276(37):34579-85. PubMed ID: 11454857
[TBL] [Abstract][Full Text] [Related]
3. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
Dussault I; Yoo HD; Lin M; Wang E; Fan M; Batta AK; Salen G; Erickson SK; Forman BM
Proc Natl Acad Sci U S A; 2003 Feb; 100(3):833-8. PubMed ID: 12569201
[TBL] [Abstract][Full Text] [Related]
4. Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism.
Je YT; Sim WC; Kim DG; Jung BH; Shin HS; Lee BH
Arch Toxicol; 2015 Apr; 89(4):579-89. PubMed ID: 24853400
[TBL] [Abstract][Full Text] [Related]
5. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.
Griffiths WJ; Crick PJ; Meljon A; Theofilopoulos S; Abdel-Khalik J; Yutuc E; Parker JE; Kelly DE; Kelly SL; Arenas E; Wang Y
Biochim Biophys Acta Mol Cell Biol Lipids; 2019 Feb; 1864(2):191-211. PubMed ID: 30471425
[TBL] [Abstract][Full Text] [Related]
6. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Staudinger J; Liu Y; Madan A; Habeebu S; Klaassen CD
Drug Metab Dispos; 2001 Nov; 29(11):1467-72. PubMed ID: 11602523
[TBL] [Abstract][Full Text] [Related]
7. Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.
Honda A; Salen G; Matsuzaki Y; Batta AK; Xu G; Leitersdorf E; Tint GS; Erickson SK; Tanaka N; Shefer S
J Lipid Res; 2001 Feb; 42(2):291-300. PubMed ID: 11181760
[TBL] [Abstract][Full Text] [Related]
8. The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
Ourlin JC; Lasserre F; Pineau T; Fabre JM; Sa-Cunha A; Maurel P; Vilarem MJ; Pascussi JM
Mol Endocrinol; 2003 Sep; 17(9):1693-703. PubMed ID: 12805410
[TBL] [Abstract][Full Text] [Related]
9. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
Ricketts ML; Boekschoten MV; Kreeft AJ; Hooiveld GJ; Moen CJ; Müller M; Frants RR; Kasanmoentalib S; Post SM; Princen HM; Porter JG; Katan MB; Hofker MH; Moore DD
Mol Endocrinol; 2007 Jul; 21(7):1603-16. PubMed ID: 17456796
[TBL] [Abstract][Full Text] [Related]
10. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Jones SA; Moore LB; Shenk JL; Wisely GB; Hamilton GA; McKee DD; Tomkinson NC; LeCluyse EL; Lambert MH; Willson TM; Kliewer SA; Moore JT
Mol Endocrinol; 2000 Jan; 14(1):27-39. PubMed ID: 10628745
[TBL] [Abstract][Full Text] [Related]
11. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
Bhalla S; Ozalp C; Fang S; Xiang L; Kemper JK
J Biol Chem; 2004 Oct; 279(43):45139-47. PubMed ID: 15322103
[TBL] [Abstract][Full Text] [Related]
12. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
Stedman CA; Liddle C; Coulter SA; Sonoda J; Alvarez JG; Moore DD; Evans RM; Downes M
Proc Natl Acad Sci U S A; 2005 Feb; 102(6):2063-8. PubMed ID: 15684063
[TBL] [Abstract][Full Text] [Related]
13. Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression.
Zhao LY; Xu JY; Shi Z; Englert NA; Zhang SY
Biochem Pharmacol; 2017 Oct; 142():194-203. PubMed ID: 28756207
[TBL] [Abstract][Full Text] [Related]
14. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.
Zhang H; LeCulyse E; Liu L; Hu M; Matoney L; Zhu W; Yan B
Arch Biochem Biophys; 1999 Aug; 368(1):14-22. PubMed ID: 10415106
[TBL] [Abstract][Full Text] [Related]
15. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
LeCluyse EL
Chem Biol Interact; 2001 May; 134(3):283-9. PubMed ID: 11336976
[TBL] [Abstract][Full Text] [Related]
16. Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats.
Chen W; Suruga K; Nishimura N; Gouda T; Lam VN; Yokogoshi H
Life Sci; 2005 Jul; 77(7):746-57. PubMed ID: 15936349
[TBL] [Abstract][Full Text] [Related]
17. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.
Kliewer SA; Goodwin B; Willson TM
Endocr Rev; 2002 Oct; 23(5):687-702. PubMed ID: 12372848
[TBL] [Abstract][Full Text] [Related]
18. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Staudinger JL; Goodwin B; Jones SA; Hawkins-Brown D; MacKenzie KI; LaTour A; Liu Y; Klaassen CD; Brown KK; Reinhard J; Willson TM; Koller BH; Kliewer SA
Proc Natl Acad Sci U S A; 2001 Mar; 98(6):3369-74. PubMed ID: 11248085
[TBL] [Abstract][Full Text] [Related]
19. Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
Carazo A; Hyrsova L; Dusek J; Chodounska H; Horvatova A; Berka K; Bazgier V; Gan-Schreier H; Chamulitrat W; Kudova E; Pavek P
Toxicol Lett; 2017 Jan; 265():86-96. PubMed ID: 27871908
[TBL] [Abstract][Full Text] [Related]
20. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.
Gnerre C; Blättler S; Kaufmann MR; Looser R; Meyer UA
Pharmacogenetics; 2004 Oct; 14(10):635-45. PubMed ID: 15454728
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]