BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 12515494)

  • 1. Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues.
    Taylor RE; Chen Y; Beatty A; Myles DC; Zhou Y
    J Am Chem Soc; 2003 Jan; 125(1):26-7. PubMed ID: 12515494
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.
    Taylor RE; Chen Y; Galvin GM; Pabba PK
    Org Biomol Chem; 2004 Jan; 2(1):127-32. PubMed ID: 14737671
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization.
    Feyen F; Cachoux F; Gertsch J; Wartmann M; Altmann KH
    Acc Chem Res; 2008 Jan; 41(1):21-31. PubMed ID: 18159935
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, total synthesis, and evaluation of novel open-chain epothilone analogues.
    Alhamadsheh MM; Hudson RA; Viranga Tillekeratne LM
    Org Lett; 2006 Feb; 8(4):685-8. PubMed ID: 16468742
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Five new epothilone metabolites from Sorangium cellulosum strain So0157-2.
    Wang J; Zhang H; Ying L; Wang C; Jiang N; Zhou Y; Wang H; Bai H
    J Antibiot (Tokyo); 2009 Sep; 62(9):483-7. PubMed ID: 19575038
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
    Nettles JH; Li H; Cornett B; Krahn JM; Snyder JP; Downing KH
    Science; 2004 Aug; 305(5685):866-9. PubMed ID: 15297674
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations.
    Starks CM; Zhou Y; Liu F; Licari PJ
    J Nat Prod; 2003 Oct; 66(10):1313-7. PubMed ID: 14575429
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide.
    Terracciano S; Bruno I; Bifulco G; Copper JE; Smith CD; Gomez-Paloma L; Riccio R
    J Nat Prod; 2004 Aug; 67(8):1325-31. PubMed ID: 15332850
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.
    Dietrich SA; Lindauer R; Stierlin C; Gertsch J; Matesanz R; Notararigo S; Díaz JF; Altmann KH
    Chemistry; 2009 Oct; 15(39):10144-57. PubMed ID: 19697384
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.
    Carlomagno T; Blommers MJ; Meiler J; Jahnke W; Schupp T; Petersen F; Schinzer D; Altmann KH; Griesinger C
    Angew Chem Int Ed Engl; 2003 Jun; 42(22):2511-5. PubMed ID: 12800173
    [No Abstract]   [Full Text] [Related]  

  • 11. Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.
    Rivkin A; Yoshimura F; Gabarda AE; Chou TC; Dong H; Tong WP; Danishefsky SJ
    J Am Chem Soc; 2003 Mar; 125(10):2899-901. PubMed ID: 12617656
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents.
    Matsuya Y; Kobayashi Y; Kawaguchi T; Hori A; Watanabe Y; Ishihara K; Ahmed K; Wei ZL; Yu DY; Zhao QL; Kondo T; Nemoto H
    Chemistry; 2009 Jun; 15(23):5799-813. PubMed ID: 19370747
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities.
    Sang F; Feng P; Chen J; Ding Y; Duan X; Zhai J; Ma X; Zhang B; Zhang Q; Lin J; Chen Y
    Eur J Med Chem; 2013 Oct; 68():321-32. PubMed ID: 23994325
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.
    Cachoux F; Isarno T; Wartmann M; Altmann KH
    Chembiochem; 2006 Jan; 7(1):54-7. PubMed ID: 16345113
    [No Abstract]   [Full Text] [Related]  

  • 15. C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity.
    Hearn BR; Zhang D; Li Y; Myles DC
    Org Lett; 2006 Jul; 8(14):3057-9. PubMed ID: 16805551
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and biological properties of highly potent epothilone B analogues.
    Nicolaou KC; Sasmal PK; Rassias G; Reddy MV; Altmann KH; Wartmann M; O'Brate A; Giannakakou P
    Angew Chem Int Ed Engl; 2003 Aug; 42(30):3515-20. PubMed ID: 12900969
    [No Abstract]   [Full Text] [Related]  

  • 17. Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.
    Vlahov IR; Vite GD; Kleindl PJ; Wang Y; Santhapuram HK; You F; Howard SJ; Kim SH; Lee FF; Leamon CP
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4578-81. PubMed ID: 20594844
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.
    Chou TC; Dong H; Rivkin A; Yoshimura F; Gabarda AE; Cho YS; Tong WP; Danishefsky SJ
    Angew Chem Int Ed Engl; 2003 Oct; 42(39):4762-7. PubMed ID: 14562342
    [No Abstract]   [Full Text] [Related]  

  • 19. Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.
    Yoshimura F; Rivkin A; Gabarda AE; Chou TC; Dong H; Sukenick G; Morel FF; Taylor RE; Danishefsky SJ
    Angew Chem Int Ed Engl; 2003 Jun; 42(22):2518-21. PubMed ID: 12800175
    [No Abstract]   [Full Text] [Related]  

  • 20. Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues.
    Woods LM; Arico JW; Frein JD; Sackett DL; Taylor RE
    Int J Mol Sci; 2017 Mar; 18(3):. PubMed ID: 28304361
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.