BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 12527309)

  • 1. Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).
    Laurents DV; Huyghues-Despointes BM; Bruix M; Thurlkill RL; Schell D; Newsom S; Grimsley GR; Shaw KL; Treviño S; Rico M; Briggs JM; Antosiewicz JM; Scholtz JM; Pace CN
    J Mol Biol; 2003 Jan; 325(5):1077-92. PubMed ID: 12527309
    [TBL] [Abstract][Full Text] [Related]  

  • 2. pK values of histidine residues in ribonuclease Sa: effect of salt and net charge.
    Huyghues-Despointes BM; Thurlkill RL; Daily MD; Schell D; Briggs JM; Antosiewicz JM; Pace CN; Scholtz JM
    J Mol Biol; 2003 Jan; 325(5):1093-105. PubMed ID: 12527310
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.
    Trevino SR; Gokulan K; Newsom S; Thurlkill RL; Shaw KL; Mitkevich VA; Makarov AA; Sacchettini JC; Scholtz JM; Pace CN
    J Mol Biol; 2005 Dec; 354(4):967-78. PubMed ID: 16288913
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The effect of net charge on the solubility, activity, and stability of ribonuclease Sa.
    Shaw KL; Grimsley GR; Yakovlev GI; Makarov AA; Pace CN
    Protein Sci; 2001 Jun; 10(6):1206-15. PubMed ID: 11369859
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hydrogen bonding markedly reduces the pK of buried carboxyl groups in proteins.
    Thurlkill RL; Grimsley GR; Scholtz JM; Pace CN
    J Mol Biol; 2006 Sep; 362(3):594-604. PubMed ID: 16934292
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Charge-charge interactions are the primary determinants of the pK values of the ionizable groups in Ribonuclease T1.
    Pace CN; Huyghues-Despointes BM; Briggs JM; Grimsley GR; Scholtz JM
    Biophys Chem; 2002 Dec; 101-102():211-9. PubMed ID: 12488002
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tyrosine hydrogen bonds make a large contribution to protein stability.
    Pace CN; Horn G; Hebert EJ; Bechert J; Shaw K; Urbanikova L; Scholtz JM; Sevcik J
    J Mol Biol; 2001 Sep; 312(2):393-404. PubMed ID: 11554795
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1.
    Hebert EJ; Giletto A; Sevcik J; Urbanikova L; Wilson KS; Dauter Z; Pace CN
    Biochemistry; 1998 Nov; 37(46):16192-200. PubMed ID: 9819211
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Empirical relationships between protein structure and carboxyl pKa values in proteins.
    Forsyth WR; Antosiewicz JM; Robertson AD
    Proteins; 2002 Aug; 48(2):388-403. PubMed ID: 12112705
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ribonuclease Sa conformational stability studied by NMR-monitored hydrogen exchange.
    Laurents DV; Scholtz JM; Rico M; Pace CN; Bruix M
    Biochemistry; 2005 May; 44(21):7644-55. PubMed ID: 15909979
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic.
    Ilinskaya ON; Dreyer F; Mitkevich VA; Shaw KL; Pace CN; Makarov AA
    Protein Sci; 2002 Oct; 11(10):2522-5. PubMed ID: 12237473
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Determination of the dipole moments of RNAse SA wild type and a basic mutant.
    Chari R; Singh SN; Yadav S; Brems DN; Kalonia DS
    Proteins; 2012 Apr; 80(4):1041-52. PubMed ID: 22213585
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dissecting structural and electrostatic interactions of charged groups in alpha-sarcin. An NMR study of some mutants involving the catalytic residues.
    García-Mayoral MF; Pérez-Cañadillas JM; Santoro J; Ibarra-Molero B; Sanchez-Ruiz JM; Lacadena J; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
    Biochemistry; 2003 Nov; 42(45):13122-33. PubMed ID: 14609322
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Charge-charge interactions in the denatured state influence the folding kinetics of ribonuclease Sa.
    Trefethen JM; Pace CN; Scholtz JM; Brems DN
    Protein Sci; 2005 Jul; 14(7):1934-8. PubMed ID: 15937282
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Contribution of active site residues to the activity and thermal stability of ribonuclease Sa.
    Yakovlev GI; Mitkevich VA; Shaw KL; Trevino S; Newsom S; Pace CN; Makarov AA
    Protein Sci; 2003 Oct; 12(10):2367-73. PubMed ID: 14500895
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
    Joshi MD; Sidhu G; Nielsen JE; Brayer GD; Withers SG; McIntosh LP
    Biochemistry; 2001 Aug; 40(34):10115-39. PubMed ID: 11513590
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Contribution of single tryptophan residues to the fluorescence and stability of ribonuclease Sa.
    Alston RW; Urbanikova L; Sevcik J; Lasagna M; Reinhart GD; Scholtz JM; Pace CN
    Biophys J; 2004 Dec; 87(6):4036-47. PubMed ID: 15377518
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A statistical approach to the prediction of pK(a) values in proteins.
    He Y; Xu J; Pan XM
    Proteins; 2007 Oct; 69(1):75-82. PubMed ID: 17588227
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recognition of RNase Sa by the inhibitor barstar: structure of the complex at 1.7 A resolution.
    Sevcík J; Urbanikova L; Dauter Z; Wilson KS
    Acta Crystallogr D Biol Crystallogr; 1998 Sep; 54(Pt 5):954-63. PubMed ID: 9757110
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Charge-charge interactions influence the denatured state ensemble and contribute to protein stability.
    Pace CN; Alston RW; Shaw KL
    Protein Sci; 2000 Jul; 9(7):1395-8. PubMed ID: 10933506
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.