BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 12527386)

  • 1. Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.
    Pérez-Cañadilllas JM; García-Mayoral MF; Laurents DV; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
    FEBS Lett; 2003 Jan; 534(1-3):197-201. PubMed ID: 12527386
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dissecting structural and electrostatic interactions of charged groups in alpha-sarcin. An NMR study of some mutants involving the catalytic residues.
    García-Mayoral MF; Pérez-Cañadillas JM; Santoro J; Ibarra-Molero B; Sanchez-Ruiz JM; Lacadena J; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
    Biochemistry; 2003 Nov; 42(45):13122-33. PubMed ID: 14609322
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of pKa values and titration shifts in the cytotoxic ribonuclease alpha-sarcin by NMR. Relationship between electrostatic interactions, structure, and catalytic function.
    Pérez-Cañadillas JM; Campos-Olivas R; Lacadena J; Martínez del Pozo A; Gavilanes JG; Santoro J; Rico M; Bruix M
    Biochemistry; 1998 Nov; 37(45):15865-76. PubMed ID: 9843392
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity.
    Pérez-Cañadillas JM; Santoro J; Campos-Olivas R; Lacadena J; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
    J Mol Biol; 2000 Jun; 299(4):1061-73. PubMed ID: 10843858
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin.
    Lacadena J; Martínez del Pozo A; Martínez-Ruiz A; Pérez-Cañadillas JM; Bruix M; Mancheño JM; Oñaderra M; Gavilanes JG
    Proteins; 1999 Nov; 37(3):474-84. PubMed ID: 10591106
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein.
    Masip M; García-Ortega L; Olmo N; García-Mayoral MF; Pérez-Cañadillas JM; Bruix M; Oñaderra M; Martínez del Pozo A; Gavilanes JG
    Protein Sci; 2003 Jan; 12(1):161-9. PubMed ID: 12493839
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A comprehensive analysis of the computed tautomer fractions of the imidazole ring of histidines in Loligo vulgaris.
    Vorobjev YN; Scheraga HA; Vila JA
    J Biomol Struct Dyn; 2018 Sep; 36(12):3094-3105. PubMed ID: 28884632
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of alpha-sarcin.
    Alvarez-García E; García-Ortega L; Verdún Y; Bruix M; Martínez del Pozo A; Gavilanes JG
    Biol Chem; 2006 May; 387(5):535-41. PubMed ID: 16740124
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Minimized natural versions of fungal ribotoxins show improved active site plasticity.
    Maestro-López M; Olombrada M; García-Ortega L; Serrano-González D; Lacadena J; Oñaderra M; Gavilanes JG; Martínez-Del-Pozo Á
    Arch Biochem Biophys; 2017 Apr; 619():45-53. PubMed ID: 28283321
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Involvement of the amino-terminal beta-hairpin of the Aspergillus ribotoxins on the interaction with membranes and nonspecific ribonuclease activity.
    García-Ortega L; Lacadena J; Mancheño JM; Oñaderra M; Kao R; Davies J; Olmo N; Pozo AM ; Gavilanes JG
    Protein Sci; 2001 Aug; 10(8):1658-68. PubMed ID: 11468362
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NMR structure of the noncytotoxic alpha-sarcin mutant Delta(7-22): the importance of the native conformation of peripheral loops for activity.
    García-Mayoral MF; García-Ortega L; Lillo MP; Santoro J; Martínez del Pozo A; Gavilanes JG; Rico M; Bruix M
    Protein Sci; 2004 Apr; 13(4):1000-11. PubMed ID: 15044731
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins.
    Herrero-Galán E; García-Ortega L; Lacadena J; Martínez-Del-Pozo A; Olmo N; Gavilanes JG; Oñaderra M
    Biochimie; 2012 Feb; 94(2):427-33. PubMed ID: 21871524
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
    Korennykh AV; Piccirilli JA; Correll CC
    Nat Struct Mol Biol; 2006 May; 13(5):436-43. PubMed ID: 16604082
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin.
    Lacadena J; Mancheño JM; Martinez-Ruiz A; Martínez del Pozo A; Gasset M; Oñaderra M; Gavilanes JG
    Biochem J; 1995 Jul; 309 ( Pt 2)(Pt 2):581-6. PubMed ID: 7626023
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.
    Siemer A; Masip M; Carreras N; García-Ortega L; Oñaderra M; Bruix M; Del Pozo AM; Gavilanes JG
    Biol Chem; 2004 Dec; 385(12):1165-70. PubMed ID: 15653429
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fungal ribotoxins: molecular dissection of a family of natural killers.
    Lacadena J; Alvarez-García E; Carreras-Sangrà N; Herrero-Galán E; Alegre-Cebollada J; García-Ortega L; Oñaderra M; Gavilanes JG; Martínez del Pozo A
    FEMS Microbiol Rev; 2007 Mar; 31(2):212-37. PubMed ID: 17253975
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin.
    Masip M; Lacadena J; Mancheño JM; Oñaderra M; Martínez-Ruiz A; Martínez del Pozo A; Gavilanes JG
    Eur J Biochem; 2001 Dec; 268(23):6190-6. PubMed ID: 11733014
    [TBL] [Abstract][Full Text] [Related]  

  • 18. pH-Dependent conformational stability of the ribotoxin alpha-sarcin and four active site charge substitution variants.
    García-Mayoral MF; del Pozo AM; Campos-Olivas R; Gavilanes JG; Santoro J; Rico M; Laurents DV; Bruix M
    Biochemistry; 2006 Nov; 45(46):13705-18. PubMed ID: 17105190
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The crystal structure of ribonuclease Rh from Rhizopus niveus at 2.0 A resolution.
    Kurihara H; Nonaka T; Mitsui Y; Ohgi K; Irie M; Nakamura KT
    J Mol Biol; 1996 Jan; 255(2):310-20. PubMed ID: 8551522
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Predictive study of the conformation of the cytotoxic protein alpha-sarcin: a structural model to explain alpha-sarcin-membrane interaction.
    Mancheño JM; Gasset M; Lacadena J; Martínez del Pozo A; Oñaderra M; Gavilanes JG
    J Theor Biol; 1995 Feb; 172(3):259-67. PubMed ID: 7715196
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.