BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

302 related articles for article (PubMed ID: 12542699)

  • 1. Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.
    Sernee MF; Evin G; Culvenor JG; Villadangos JA; Beyreuther K; Masters CL; Cappai R
    Eur J Biochem; 2003 Feb; 270(3):495-506. PubMed ID: 12542699
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
    Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
    J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
    Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
    Kim H; Ki H; Park HS; Kim K
    J Biol Chem; 2005 Jun; 280(23):22462-72. PubMed ID: 15797863
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D; Kienlen-Campard P; Octave JN
    J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
    Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
    J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
    Octave JN; Essalmani R; Tasiaux B; Menager J; Czech C; Mercken L
    J Biol Chem; 2000 Jan; 275(3):1525-8. PubMed ID: 10636839
    [TBL] [Abstract][Full Text] [Related]  

  • 10. gamma-Secretase inhibitors as molecular probes of presenilin function.
    Wolfe MS
    J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
    Lammich S; Okochi M; Takeda M; Kaether C; Capell A; Zimmer AK; Edbauer D; Walter J; Steiner H; Haass C
    J Biol Chem; 2002 Nov; 277(47):44754-9. PubMed ID: 12223485
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
    Evin G; Sharples RA; Weidemann A; Reinhard FB; Carbone V; Culvenor JG; Holsinger RM; Sernee MF; Beyreuther K; Masters CL
    Biochemistry; 2001 Jul; 40(28):8359-68. PubMed ID: 11444983
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease.
    Tomita T; Iwatsubo T
    Drug News Perspect; 2004 Jun; 17(5):321-5. PubMed ID: 15334182
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A portrait of Alzheimer secretases--new features and familiar faces.
    Esler WP; Wolfe MS
    Science; 2001 Aug; 293(5534):1449-54. PubMed ID: 11520976
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 16. APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.
    Wolfe MS
    Int Immunopharmacol; 2002 Dec; 2(13-14):1919-29. PubMed ID: 12489805
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Secretase as a target for Alzheimer's disease.
    Wolfe MS
    Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
    LaVoie MJ; Selkoe DJ
    J Biol Chem; 2003 Sep; 278(36):34427-37. PubMed ID: 12826675
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.