139 related articles for article (PubMed ID: 12556458)
1. gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.
Grimm HS; Beher D; Lichtenthaler SF; Shearman MS; Beyreuther K; Hartmann T
J Biol Chem; 2003 Apr; 278(15):13077-85. PubMed ID: 12556458
[TBL] [Abstract][Full Text] [Related]
2. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
[TBL] [Abstract][Full Text] [Related]
3. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
Beher D; Wrigley JD; Owens AP; Shearman MS
J Neurochem; 2002 Aug; 82(3):563-75. PubMed ID: 12153480
[TBL] [Abstract][Full Text] [Related]
4. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
[TBL] [Abstract][Full Text] [Related]
5. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
[TBL] [Abstract][Full Text] [Related]
6. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
Fluhrer R; Multhaup G; Schlicksupp A; Okochi M; Takeda M; Lammich S; Willem M; Westmeyer G; Bode W; Walter J; Haass C
J Biol Chem; 2003 Feb; 278(8):5531-8. PubMed ID: 12471021
[TBL] [Abstract][Full Text] [Related]
7. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
[TBL] [Abstract][Full Text] [Related]
8. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
J Biol Chem; 2000 Nov; 275(47):36794-802. PubMed ID: 10962005
[TBL] [Abstract][Full Text] [Related]
9. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
[TBL] [Abstract][Full Text] [Related]
10. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Pitsi D; Octave JN
J Biol Chem; 2004 Jun; 279(24):25333-8. PubMed ID: 15087467
[TBL] [Abstract][Full Text] [Related]
11. An empirical model of gamma-secretase activity.
Murphy MP; Wang R; Fraser PE; Fauq A; Golde TE
Ann N Y Acad Sci; 2000; 920():233-40. PubMed ID: 11193156
[TBL] [Abstract][Full Text] [Related]
12. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
13. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Lammich S; Kojro E; Postina R; Gilbert S; Pfeiffer R; Jasionowski M; Haass C; Fahrenholz F
Proc Natl Acad Sci U S A; 1999 Mar; 96(7):3922-7. PubMed ID: 10097139
[TBL] [Abstract][Full Text] [Related]
14. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
Pitsi D; Kienlen-Campard P; Octave JN
J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
[TBL] [Abstract][Full Text] [Related]
15. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
16. Gamma-secretase complex assembly within the early secretory pathway.
Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C
J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316
[TBL] [Abstract][Full Text] [Related]
17. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.
Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
J Biol Chem; 2004 Jun; 279(23):23925-32. PubMed ID: 15051718
[TBL] [Abstract][Full Text] [Related]
18. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Kim SH; Yin YI; Li YM; Sisodia SS
J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788
[TBL] [Abstract][Full Text] [Related]
19. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher D; Wrigley JD; Nadin A; Evin G; Masters CL; Harrison T; Castro JL; Shearman MS
J Biol Chem; 2001 Nov; 276(48):45394-402. PubMed ID: 11574530
[TBL] [Abstract][Full Text] [Related]
20. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.
Octave JN; Essalmani R; Tasiaux B; Menager J; Czech C; Mercken L
J Biol Chem; 2000 Jan; 275(3):1525-8. PubMed ID: 10636839
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
