BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

90 related articles for article (PubMed ID: 12559972)

  • 1. Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide.
    Wang R; Griffin PR; Small EC; Thompson JE
    Arch Biochem Biophys; 2003 Feb; 410(1):7-15. PubMed ID: 12559972
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
    Liu KD; Gaffen SL; Goldsmith MA; Greene WC
    Curr Biol; 1997 Nov; 7(11):817-26. PubMed ID: 9382798
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
    Witthuhn BA; Williams MD; Kerawalla H; Uckun FM
    Leuk Lymphoma; 1999 Jan; 32(3-4):289-97. PubMed ID: 10037026
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.
    Lin L; Czerwinski R; Kelleher K; Siegel MM; Wu P; Kriz R; Aulabaugh A; Stahl M
    Biochemistry; 2009 Mar; 48(9):2021-32. PubMed ID: 19206206
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determination of the transphosphorylation sites of Jak2 kinase.
    Matsuda T; Feng J; Witthuhn BA; Sekine Y; Ihle JN
    Biochem Biophys Res Commun; 2004 Dec; 325(2):586-94. PubMed ID: 15530433
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
    Miyazaki T; Kawahara A; Fujii H; Nakagawa Y; Minami Y; Liu ZJ; Oishi I; Silvennoinen O; Witthuhn BA; Ihle JN
    Science; 1994 Nov; 266(5187):1045-7. PubMed ID: 7973659
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
    Malabarba MG; Kirken RA; Rui H; Koettnitz K; Kawamura M; O'Shea JJ; Kalthoff FS; Farrar WL
    J Biol Chem; 1995 Apr; 270(16):9630-7. PubMed ID: 7721895
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail.
    Wang D; Huang XY; Cole PA
    Biochemistry; 2001 Feb; 40(7):2004-10. PubMed ID: 11329267
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.
    Keegan AD; Johnston JA; Tortolani PJ; McReynolds LJ; Kinzer C; O'Shea JJ; Paul WE
    Proc Natl Acad Sci U S A; 1995 Aug; 92(17):7681-5. PubMed ID: 7544000
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
    Zhou YJ; Hanson EP; Chen YQ; Magnuson K; Chen M; Swann PG; Wange RL; Changelian PS; O'Shea JJ
    Proc Natl Acad Sci U S A; 1997 Dec; 94(25):13850-5. PubMed ID: 9391116
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
    Russell SM; Johnston JA; Noguchi M; Kawamura M; Bacon CM; Friedmann M; Berg M; McVicar DW; Witthuhn BA; Silvennoinen O
    Science; 1994 Nov; 266(5187):1042-5. PubMed ID: 7973658
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.
    Nelson BH; McIntosh BC; Rosencrans LL; Greenberg PD
    Proc Natl Acad Sci U S A; 1997 Mar; 94(5):1878-83. PubMed ID: 9050873
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
    Schaper F; Gendo C; Eck M; Schmitz J; Grimm C; Anhuf D; Kerr IM; Heinrich PC
    Biochem J; 1998 Nov; 335 ( Pt 3)(Pt 3):557-65. PubMed ID: 9794795
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substrate specificity of the oncoprotein v-Fps: site-specific mutagenesis of the putative P+1 pocket.
    Konkol L; Hirai TJ; Adams JA
    Biochemistry; 2000 Jan; 39(1):255-62. PubMed ID: 10625501
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.
    Haan C; Is'harc H; Hermanns HM; Schmitz-Van De Leur H; Kerr IM; Heinrich PC; Grötzinger J; Behrmann I
    J Biol Chem; 2001 Oct; 276(40):37451-8. PubMed ID: 11468294
    [TBL] [Abstract][Full Text] [Related]  

  • 16. IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
    Murata T; Noguchi PD; Puri RK
    J Immunol; 1996 Apr; 156(8):2972-8. PubMed ID: 8609418
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
    Cacalano NA; Migone TS; Bazan F; Hanson EP; Chen M; Candotti F; O'Shea JJ; Johnston JA
    EMBO J; 1999 Mar; 18(6):1549-58. PubMed ID: 10075926
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
    Bacon CM; McVicar DW; Ortaldo JR; Rees RC; O'Shea JJ; Johnston JA
    J Exp Med; 1995 Jan; 181(1):399-404. PubMed ID: 7528775
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of IL-2 signaling.
    Higuchi M; Asao H; Tanaka N; Oda K; Takeshita T; Sugamura K
    Leukemia; 1997 Apr; 11 Suppl 3():416-7. PubMed ID: 9209410
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rate-determining steps for tyrosine phosphorylation by the kinase domain of v-fps.
    Wang C; Lee TR; Lawrence DS; Adams JA
    Biochemistry; 1996 Feb; 35(5):1533-9. PubMed ID: 8634284
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.