BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 12563278)

  • 1. In situ assembly of enzyme inhibitors using extended tethering.
    Erlanson DA; Lam JW; Wiesmann C; Luong TN; Simmons RL; DeLano WL; Choong IC; Burdett MT; Flanagan WM; Lee D; Gordon EM; O'Brien T
    Nat Biotechnol; 2003 Mar; 21(3):308-14. PubMed ID: 12563278
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
    Yang W; Fucini RV; Fahr BT; Randal M; Lind KE; Lam MB; Lu W; Lu Y; Cary DR; Romanowski MJ; Colussi D; Pietrak B; Allison TJ; Munshi SK; Penny DM; Pham P; Sun J; Thomas AE; Wilkinson JM; Jacobs JW; McDowell RS; Ballinger MD
    Biochemistry; 2009 Jun; 48(21):4488-96. PubMed ID: 19284778
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.
    Erlanson DA; McDowell RS; He MM; Randal M; Simmons RL; Kung J; Waight A; Hansen SK
    J Am Chem Soc; 2003 May; 125(19):5602-3. PubMed ID: 12733877
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7.
    Goode DR; Sharma AK; Hergenrother PJ
    Org Lett; 2005 Aug; 7(16):3529-32. PubMed ID: 16048334
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score.
    Yoshimori A; Takasawa R; Tanuma S
    BMC Pharmacol; 2004 May; 4():7. PubMed ID: 15154972
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.
    Cancilla MT; He MM; Viswanathan N; Simmons RL; Taylor M; Fung AD; Cao K; Erlanson DA
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3978-81. PubMed ID: 18579375
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
    Becker JW; Rotonda J; Soisson SM; Aspiotis R; Bayly C; Francoeur S; Gallant M; Garcia-Calvo M; Giroux A; Grimm E; Han Y; McKay D; Nicholson DW; Peterson E; Renaud J; Roy S; Thornberry N; Zamboni R
    J Med Chem; 2004 May; 47(10):2466-74. PubMed ID: 15115390
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural analysis of caspase-1 inhibitors derived from Tethering.
    O'Brien T; Fahr BT; Sopko MM; Lam JW; Waal ND; Raimundo BC; Purkey HE; Pham P; Romanowski MJ
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 May; 61(Pt 5):451-8. PubMed ID: 16511067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformationally restricted hydantoin-based peptidomimetics as inhibitors of caspase-3 with basic groups allowed at the S3 enzyme subsite.
    Vázquez J; García-Jareño A; Mondragón L; Rubio-Martinez J; Pérez-Payá E; Albericio F
    ChemMedChem; 2008 Jun; 3(6):979-85. PubMed ID: 18393268
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries.
    Dixon SM; Li P; Liu R; Wolosker H; Lam KS; Kurth MJ; Toney MD
    J Med Chem; 2006 Apr; 49(8):2388-97. PubMed ID: 16610782
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Reversible inhibition of caspase-3 activity by iron(III): potential role in physiological control of apoptosis.
    Sliskovic I; Mutus B
    FEBS Lett; 2006 Apr; 580(9):2233-7. PubMed ID: 16579993
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dynamic combinatorial self-assembly of cyclophilin hCyp-18 ligands through oxorhenium coordination.
    Clavaud C; Le Gal J; Thai R; Moutiez M; Dugave C
    Chembiochem; 2008 Jul; 9(11):1823-9. PubMed ID: 18604836
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.
    Kravchenko DV; Kuzovkova YA; Kysil VM; Tkachenko SE; Maliarchouk S; Okun IM; Balakin KV; Ivachtchenko AV
    J Med Chem; 2005 Jun; 48(11):3680-3. PubMed ID: 15916416
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformational restrictions in the active site of unliganded human caspase-3.
    Ni CZ; Li C; Wu JC; Spada AP; Ely KR
    J Mol Recognit; 2003; 16(3):121-4. PubMed ID: 12833566
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
    Berger AB; Witte MD; Denault JB; Sadaghiani AM; Sexton KM; Salvesen GS; Bogyo M
    Mol Cell; 2006 Aug; 23(4):509-21. PubMed ID: 16916639
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
    Mellon C; Aspiotis R; Black CW; Bayly CI; Grimm EL; Giroux A; Han Y; Isabel E; McKay DJ; Nicholson DW; Rasper DM; Roy S; Tam J; Thornberry NA; Vaillancourt JP; Xanthoudakis S; Zamboni R
    Bioorg Med Chem Lett; 2005 Sep; 15(17):3886-90. PubMed ID: 16023344
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pramanicin induces apoptosis in Jurkat leukemia cells: a role for JNK, p38 and caspase activation.
    Kutuk O; Pedrech A; Harrison P; Basaga H
    Apoptosis; 2005 May; 10(3):597-609. PubMed ID: 15909121
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
    Chen YH; Zhang YH; Zhang HJ; Liu DZ; Gu M; Li JY; Wu F; Zhu XZ; Li J; Nan FJ
    J Med Chem; 2006 Mar; 49(5):1613-23. PubMed ID: 16509578
    [TBL] [Abstract][Full Text] [Related]  

  • 19. "Click" synthesis of small-molecule inhibitors targeting caspases.
    Ng SL; Yang PY; Chen KY; Srinivasan R; Yao SQ
    Org Biomol Chem; 2008 Mar; 6(5):844-7. PubMed ID: 18292873
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Solid phase synthesis of selective caspase-3 peptide inhibitors.
    Grimm EL; Roy B; Aspiotis R; Bayly CI; Nicholson DW; Rasper DM; Renaud J; Roy S; Tam J; Tawa P; Vaillancourt JP; Xanthoudakis S; Zamboni RJ
    Bioorg Med Chem; 2004 Mar; 12(5):845-51. PubMed ID: 14980595
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.