These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 12565952)

  • 1. p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.
    Hunt JA; Kallashi F; Ruzek RD; Sinclair PJ; Ita I; McCormick SX; Pivnichny JV; Hop CE; Kumar S; Wang Z; O'Keefe SJ; O'Neill EA; Porter G; Thompson JE; Woods A; Zaller DM; Doherty JB
    Bioorg Med Chem Lett; 2003 Feb; 13(3):467-70. PubMed ID: 12565952
    [TBL] [Abstract][Full Text] [Related]  

  • 2. p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
    Bao J; Hunt JA; Miao S; Rupprecht KM; Stelmach JE; Liu L; Ruzek RD; Sinclair PJ; Pivnichny JV; Hop CE; Kumar S; Zaller DM; Shoop WL; O'neill EA; O'keefe SJ; Thompson CM; Cubbon RM; Wang R; Zhang WX; Thompson JE; Doherty JB
    Bioorg Med Chem Lett; 2006 Jan; 16(1):64-8. PubMed ID: 16242322
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
    Stelmach JE; Liu L; Patel SB; Pivnichny JV; Scapin G; Singh S; Hop CE; Wang Z; Strauss JR; Cameron PM; Nichols EA; O'Keefe SJ; O'Neill EA; Schmatz DM; Schwartz CD; Thompson CM; Zaller DM; Doherty JB
    Bioorg Med Chem Lett; 2003 Jan; 13(2):277-80. PubMed ID: 12482439
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
    Angibaud P; Bourdrez X; End DW; Freyne E; Janicot M; Lezouret P; Ligny Y; Mannens G; Damsch S; Mevellec L; Meyer C; Muller P; Pilatte I; Poncelet V; Roux B; Smets G; Van Dun J; Van Remoortere P; Venet M; Wouters W
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4365-9. PubMed ID: 14643327
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis development of a naphthyridinone p38 kinase inhibitor.
    Chung JY; Cvetovich RJ
    Curr Opin Drug Discov Devel; 2006 Nov; 9(6):792-805. PubMed ID: 17117687
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
    Liverton NJ; Butcher JW; Claiborne CF; Claremon DA; Libby BE; Nguyen KT; Pitzenberger SM; Selnick HG; Smith GR; Tebben A; Vacca JP; Varga SL; Agarwal L; Dancheck K; Forsyth AJ; Fletcher DS; Frantz B; Hanlon WA; Harper CF; Hofsess SJ; Kostura M; Lin J; Luell S; O'Neill EA; O'Keefe SJ
    J Med Chem; 1999 Jun; 42(12):2180-90. PubMed ID: 10377223
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors.
    Schlapbach A; Heng R; Di Padova F
    Bioorg Med Chem Lett; 2004 Jan; 14(2):357-60. PubMed ID: 14698158
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
    Ferraris D; Ko YS; Pahutski T; Ficco RP; Serdyuk L; Alemu C; Bradford C; Chiou T; Hoover R; Huang S; Lautar S; Liang S; Lin Q; Lu MX; Mooney M; Morgan L; Qian Y; Tran S; Williams LR; Wu QY; Zhang J; Zou Y; Kalish V
    J Med Chem; 2003 Jul; 46(14):3138-51. PubMed ID: 12825952
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Imidazopyrimidines, potent inhibitors of p38 MAP kinase.
    Rupert KC; Henry JR; Dodd JH; Wadsworth SA; Cavender DE; Olini GC; Fahmy B; Siekierka JJ
    Bioorg Med Chem Lett; 2003 Feb; 13(3):347-50. PubMed ID: 12565927
    [TBL] [Abstract][Full Text] [Related]  

  • 10. SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
    Revesz L; Di Padova FE; Buhl T; Feifel R; Gram H; Hiestand P; Manning U; Wolf R; Zimmerlin AG
    Bioorg Med Chem Lett; 2002 Aug; 12(16):2109-12. PubMed ID: 12127515
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors.
    McKenna JM; Halley F; Souness JE; McLay IM; Pickett SD; Collis AJ; Page K; Ahmed I
    J Med Chem; 2002 May; 45(11):2173-84. PubMed ID: 12014955
    [TBL] [Abstract][Full Text] [Related]  

  • 12. p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.
    Natarajan SR; Wisnoski DD; Singh SB; Stelmach JE; O'Neill EA; Schwartz CD; Thompson CM; Fitzgerald CE; O'Keefe SJ; Kumar S; Hop CE; Zaller DM; Schmatz DM; Doherty JB
    Bioorg Med Chem Lett; 2003 Jan; 13(2):273-6. PubMed ID: 12482438
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents.
    Sakurai N; Sano M; Hirayama F; Kuroda T; Uemori S; Moriguchi A; Yamamoto K; Ikeda Y; Kawakita T
    Bioorg Med Chem Lett; 1998 Aug; 8(16):2185-90. PubMed ID: 9873510
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted derivatives.
    Remuzon P; Bouzard D; Cesare PD; Essiz M; Jacquet JP; Kiechel JR; Ledoussal B; Kessler RE; Fung-Tomc J
    J Med Chem; 1991 Jan; 34(1):29-37. PubMed ID: 1992128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.
    Revesz L; Di Padova FE; Buhl T; Feifel R; Gram H; Hiestand P; Manning U; Zimmerlin AG
    Bioorg Med Chem Lett; 2000 Jun; 10(11):1261-4. PubMed ID: 10866395
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel selective hindlimb vasodilators: synthesis and biological activity of 1-acyl-4-aminopiperidine derivatives.
    Teramoto S; Tanaka M; Shimizu H; Fujioka T; Tabusa F; Imaizumi T; Yoshida K; Fujiki H; Mori T; Sumida T; Tominaga M
    J Med Chem; 2003 Jul; 46(14):3033-44. PubMed ID: 12825942
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-activity relationships of non-peptide vasopressin V1a antagonists: 1-(1-multi-substituted benzoyl 4-piperidyl)-3,4-dihydro-2(1H)-quinolinones.
    Kondo K; Ogawa H; Nakaya K; Tominaga M; Yabuuchi Y
    Chem Pharm Bull (Tokyo); 1996 Apr; 44(4):725-33. PubMed ID: 8681404
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antitumor activity of some new substituted quinolin-4-one and 1,7-naphthyridin-4-one analogs.
    el-Subbagh HI; Abadi AH; al-Khawad IE; al-Rashood KA
    Arch Pharm (Weinheim); 1999 Jan; 332(1):19-24. PubMed ID: 10073140
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, antimicrobial evaluation, and docking studies of novel 4-substituted quinazoline derivatives as DNA-gyrase inhibitors.
    Boyapati S; Kulandaivelu U; Sangu S; Vanga MR
    Arch Pharm (Weinheim); 2010 Oct; 343(10):570-6. PubMed ID: 20941729
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.
    Jiang J; DeVita RJ; Goulet MT; Wyvratt MJ; Lo JL; Ren N; Yudkovitz JB; Cui J; Yang YT; Cheng K; Rohrer SP
    Bioorg Med Chem Lett; 2004 Apr; 14(7):1795-8. PubMed ID: 15026074
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.