BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

332 related articles for article (PubMed ID: 12570378)

  • 1. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
    Kim MY; Duan W; Gleason-Guzman M; Hurley LH
    J Med Chem; 2003 Feb; 46(4):571-83. PubMed ID: 12570378
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
    Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
    J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.
    Vispé S; Vandenberghe I; Robin M; Annereau JP; Créancier L; Pique V; Galy JP; Kruczynski A; Barret JM; Bailly C
    Biochem Pharmacol; 2007 Jun; 73(12):1863-72. PubMed ID: 17391647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.
    Duan W; Rangan A; Vankayalapati H; Kim MY; Zeng Q; Sun D; Han H; Fedoroff OY; Nishioka D; Rha SY; Izbicka E; Von Hoff DD; Hurley LH
    Mol Cancer Ther; 2001 Dec; 1(2):103-20. PubMed ID: 12467228
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
    Kim MY; Na Y; Vankayalapati H; Gleason-Guzman M; Hurley LH
    J Med Chem; 2003 Jul; 46(14):2958-72. PubMed ID: 12825936
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design.
    Missailidis S; Stanslas J; Modi C; Ellis MJ; Robins RA; Laughton CA; Stevens MF
    Oncol Res; 2002; 13(3):175-89. PubMed ID: 12549627
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
    Guan J; Zhu XK; Tachibana Y; Bastow KF; Brossi A; Hamel E; Lee KH
    J Med Chem; 1998 May; 41(11):1956-61. PubMed ID: 9599244
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
    Martins C; Gunaratnam M; Stuart J; Makwana V; Greciano O; Reszka AP; Kelland LR; Neidle S
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2293-8. PubMed ID: 17276687
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
    Anizon F; Belin L; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Sevère D; Riou JF; Bailly C; Fabbro D; Meyer T
    J Med Chem; 1997 Oct; 40(21):3456-65. PubMed ID: 9341921
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
    Zhu XK; Guan J; Tachibana Y; Bastow KF; Cho SJ; Cheng HH; Cheng YC; Gurwith M; Lee KH
    J Med Chem; 1999 Jul; 42(13):2441-6. PubMed ID: 10395485
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
    Perry PJ; Reszka AP; Wood AA; Read MA; Gowan SM; Dosanjh HS; Trent JO; Jenkins TC; Kelland LR; Neidle S
    J Med Chem; 1998 Nov; 41(24):4873-84. PubMed ID: 9822556
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of rotenoid derivatives with cytotoxic and topoisomerase II inhibitory activities.
    Sangthong S; Krusong K; Ngamrojanavanich N; Vilaivan T; Puthong S; Chandchawan S; Muangsin N
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4813-8. PubMed ID: 21741833
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding affinity and topoisomerase II inhibition.
    Bielawska A; Bielawski K; Wołczyński S; Anchim T
    Arch Pharm (Weinheim); 2003 Aug; 336(6-7):293-9. PubMed ID: 12953217
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Methoxy- and methyl-, methoxy-5,6,11-trimethyl-6H-indolo [2,3-b]quinolinium derivatives as novel cytotoxic agents and DNA topoisomerase II inhibitors.
    Kaczmarek L; Peczyńska-Czoch W; Opolski A; Wietrzyk J; Marcinkowska E; Boratyński J; Osiadacz J
    Anticancer Res; 1998; 18(4C):3133-8. PubMed ID: 9713522
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Basnet A; Thapa P; Karki R; Na Y; Jahng Y; Jeong BS; Jeong TC; Lee CS; Lee ES
    Bioorg Med Chem; 2007 Jul; 15(13):4351-9. PubMed ID: 17493824
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.
    Rothenborg-Jensen L; Hansen HF; Wessel I; Nitiss JL; Schmidt G; Jensen PB; Sehested M; Jensen LH
    Anticancer Drug Des; 2001 Dec; 16(6):305-15. PubMed ID: 12375883
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
    Kim JS; Rhee HK; Park HJ; Lee IK; Lee SK; Suh ME; Lee HJ; Ryu CK; Choo HY
    Bioorg Med Chem; 2007 Jan; 15(1):451-7. PubMed ID: 17035025
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
    Perni RB; Wentland MP; Huang JI; Powles RG; Aldous S; Klingbeil KM; Peverly AD; Robinson RG; Corbett TH; Jones JL; Mattes KC; Rake JB; Coughlin SA
    J Med Chem; 1998 Sep; 41(19):3645-54. PubMed ID: 9733489
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.