BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

313 related articles for article (PubMed ID: 12578355)

  • 1. 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.
    Watkins RE; Maglich JM; Moore LB; Wisely GB; Noble SM; Davis-Searles PR; Lambert MH; Kliewer SA; Redinbo MR
    Biochemistry; 2003 Feb; 42(6):1430-8. PubMed ID: 12578355
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.
    Zhou C; Tabb MM; Sadatrafiei A; Grün F; Sun A; Blumberg B
    J Clin Immunol; 2004 Nov; 24(6):623-36. PubMed ID: 15622447
    [TBL] [Abstract][Full Text] [Related]  

  • 3. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
    Moore LB; Goodwin B; Jones SA; Wisely GB; Serabjit-Singh CJ; Willson TM; Collins JL; Kliewer SA
    Proc Natl Acad Sci U S A; 2000 Jun; 97(13):7500-2. PubMed ID: 10852961
    [TBL] [Abstract][Full Text] [Related]  

  • 4. St John's wort, a herbal antidepressant, activates the steroid X receptor.
    Wentworth JM; Agostini M; Love J; Schwabe JW; Chatterjee VK
    J Endocrinol; 2000 Sep; 166(3):R11-6. PubMed ID: 10974665
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.
    Komoroski BJ; Parise RA; Egorin MJ; Strom SC; Venkataramanan R
    Clin Cancer Res; 2005 Oct; 11(19 Pt 1):6972-9. PubMed ID: 16203790
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
    Tian R; Koyabu N; Morimoto S; Shoyama Y; Ohtani H; Sawada Y
    Drug Metab Dispos; 2005 Apr; 33(4):547-54. PubMed ID: 15640377
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
    Gödtel-Armbrust U; Metzger A; Kroll U; Kelber O; Wojnowski L
    Naunyn Schmiedebergs Arch Pharmacol; 2007 Aug; 375(6):377-82. PubMed ID: 17593354
    [TBL] [Abstract][Full Text] [Related]  

  • 8. No activation of human pregnane X receptor by hyperforin-related phloroglucinols.
    Kandel BA; Ekins S; Leuner K; Thasler WE; Harteneck C; Zanger UM
    J Pharmacol Exp Ther; 2014 Mar; 348(3):393-400. PubMed ID: 24259679
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of hyperforin in the pharmacological activities of St. John's Wort.
    Zanoli P
    CNS Drug Rev; 2004; 10(3):203-18. PubMed ID: 15492771
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Current St John's wort research from mode of action to clinical efficacy.
    Müller WE
    Pharmacol Res; 2003 Feb; 47(2):101-9. PubMed ID: 12543057
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.
    Wang EJ; Barecki-Roach M; Johnson WW
    J Pharm Pharmacol; 2004 Jan; 56(1):123-8. PubMed ID: 14980009
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats.
    Butterweck V; Winterhoff H; Herkenham M
    Neuropsychopharmacology; 2003 Dec; 28(12):2160-8. PubMed ID: 12865894
    [TBL] [Abstract][Full Text] [Related]  

  • 13. St. John's wort.
    Lawvere S; Mahoney MC
    Am Fam Physician; 2005 Dec; 72(11):2249-54. PubMed ID: 16342849
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort.
    Choudhuri S; Valerio LG
    J Biochem Mol Toxicol; 2005; 19(1):1-11. PubMed ID: 15736155
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
    Laggner H; Schreier S; Hermann M; Exner M; Mühl A; Gmeiner BM; Kapiotis S
    Free Radic Res; 2007 Feb; 41(2):234-41. PubMed ID: 17364950
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Antidepressant activity of hyperforin conjugates of the St. John's wort, Hypericum perforatum Linn.: an experimental study.
    Muruganandam AV; Bhattacharya SK; Ghosal S
    Indian J Exp Biol; 2001 Dec; 39(12):1302-4. PubMed ID: 12018529
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
    Komoroski BJ; Zhang S; Cai H; Hutzler JM; Frye R; Tracy TS; Strom SC; Lehmann T; Ang CY; Cui YY; Venkataramanan R
    Drug Metab Dispos; 2004 May; 32(5):512-8. PubMed ID: 15100173
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
    Xue Y; Moore LB; Orans J; Peng L; Bencharit S; Kliewer SA; Redinbo MR
    Mol Endocrinol; 2007 May; 21(5):1028-38. PubMed ID: 17327420
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.
    Kliewer SA; Goodwin B; Willson TM
    Endocr Rev; 2002 Oct; 23(5):687-702. PubMed ID: 12372848
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Modulation of P-glycoprotein function by St John's wort extract and its major constituents.
    Weber CC; Kressmann S; Fricker G; Müller WE
    Pharmacopsychiatry; 2004 Nov; 37(6):292-8. PubMed ID: 15551196
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.