192 related articles for article (PubMed ID: 12578364)
1. Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach.
Ewert S; Honegger A; Plückthun A
Biochemistry; 2003 Feb; 42(6):1517-28. PubMed ID: 12578364
[TBL] [Abstract][Full Text] [Related]
2. The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains.
Jung S; Spinelli S; Schimmele B; Honegger A; Pugliese L; Cambillau C; Plückthun A
J Mol Biol; 2001 Jun; 309(3):701-16. PubMed ID: 11397090
[TBL] [Abstract][Full Text] [Related]
3. The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains.
Honegger A; Malebranche AD; Röthlisberger D; Plückthun A
Protein Eng Des Sel; 2009 Mar; 22(3):121-34. PubMed ID: 19136675
[TBL] [Abstract][Full Text] [Related]
4. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.
Knappik A; Ge L; Honegger A; Pack P; Fischer M; Wellnhofer G; Hoess A; Wölle J; Plückthun A; Virnekäs B
J Mol Biol; 2000 Feb; 296(1):57-86. PubMed ID: 10656818
[TBL] [Abstract][Full Text] [Related]
5. Improving solubility and refolding efficiency of human V(H)s by a novel mutational approach.
Tanha J; Nguyen TD; Ng A; Ryan S; Ni F; Mackenzie R
Protein Eng Des Sel; 2006 Nov; 19(11):503-9. PubMed ID: 16971398
[TBL] [Abstract][Full Text] [Related]
6. Contributions of a highly conserved VH/VL hydrogen bonding interaction to scFv folding stability and refolding efficiency.
Tan PH; Sandmaier BM; Stayton PS
Biophys J; 1998 Sep; 75(3):1473-82. PubMed ID: 9726949
[TBL] [Abstract][Full Text] [Related]
7. Analysis of the horse V(H) repertoire and comparison with the human IGHV germline genes, and sheep, cattle and pig V(H) sequences.
Almagro JC; Martinez L; Smith SL; Alagon A; Estevez J; Paniagua J
Mol Immunol; 2006 Apr; 43(11):1836-45. PubMed ID: 16337682
[TBL] [Abstract][Full Text] [Related]
8. Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold.
Jespers L; Schon O; James LC; Veprintsev D; Winter G
J Mol Biol; 2004 Apr; 337(4):893-903. PubMed ID: 15033359
[TBL] [Abstract][Full Text] [Related]
9. Biophysical properties of human antibody variable domains.
Ewert S; Huber T; Honegger A; Plückthun A
J Mol Biol; 2003 Jan; 325(3):531-53. PubMed ID: 12498801
[TBL] [Abstract][Full Text] [Related]
10. Energy-based analysis and prediction of the orientation between light- and heavy-chain antibody variable domains.
Narayanan A; Sellers BD; Jacobson MP
J Mol Biol; 2009 May; 388(5):941-53. PubMed ID: 19324053
[TBL] [Abstract][Full Text] [Related]
11. Functional mapping of conserved residues located at the VL and VH domain interface of a Fab.
Chatellier J; Van Regenmortel MH; Vernet T; Altschuh D
J Mol Biol; 1996 Nov; 264(1):1-6. PubMed ID: 8950262
[TBL] [Abstract][Full Text] [Related]
12. Conformations of the third hypervariable region in the VH domain of immunoglobulins.
Morea V; Tramontano A; Rustici M; Chothia C; Lesk AM
J Mol Biol; 1998 Jan; 275(2):269-94. PubMed ID: 9466909
[TBL] [Abstract][Full Text] [Related]
13. Exploring local and non-local interactions for protein stability by structural motif engineering.
Niggemann M; Steipe B
J Mol Biol; 2000 Feb; 296(1):181-95. PubMed ID: 10656826
[TBL] [Abstract][Full Text] [Related]
14. The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains.
Honegger A; Plückthun A
J Mol Biol; 2001 Jun; 309(3):687-99. PubMed ID: 11397089
[TBL] [Abstract][Full Text] [Related]
15. Intrabody construction and expression III: engineering hyperstable V(H) domains.
Wirtz P; Steipe B
Protein Sci; 1999 Nov; 8(11):2245-50. PubMed ID: 10595527
[TBL] [Abstract][Full Text] [Related]
16. Humanization of a highly stable single-chain antibody by structure-based antigen-binding site grafting.
Villani ME; Morea V; Consalvi V; Chiaraluce R; Desiderio A; Benvenuto E; Donini M
Mol Immunol; 2008 May; 45(9):2474-85. PubMed ID: 18313757
[TBL] [Abstract][Full Text] [Related]
17. Structure, diversity, and repertoire of VH families in the Mexican axolotl.
Golub R; Charlemagne J
J Immunol; 1998 Feb; 160(3):1233-9. PubMed ID: 9570539
[TBL] [Abstract][Full Text] [Related]
18. Design and validation of a synthetic VH repertoire with tailored diversity for protein recognition.
Almagro JC; Quintero-Hernández V; Ortiz-León M; Velandia A; Smith SL; Becerril B
J Mol Recognit; 2006; 19(5):413-22. PubMed ID: 16881059
[TBL] [Abstract][Full Text] [Related]
19. Functional mapping of conserved, surface-exposed charges of antibody variable domains.
Weidenhaupt M; Khalifa MB; Hugo N; Choulier L; Altschuh D; Vernet T
J Mol Recognit; 2002; 15(2):94-103. PubMed ID: 11954054
[TBL] [Abstract][Full Text] [Related]
20. Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.
Kügler M; Stein C; Schwenkert M; Saul D; Vockentanz L; Huber T; Wetzel SK; Scholz O; Plückthun A; Honegger A; Fey GH
Protein Eng Des Sel; 2009 Mar; 22(3):135-47. PubMed ID: 19188138
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
