195 related articles for article (PubMed ID: 12588191)
1. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
Singh R; Silva Elipe MV; Pearson PG; Arison BH; Wong BK; White R; Yu X; Burgey CS; Lin JH; Baillie TA
Chem Res Toxicol; 2003 Feb; 16(2):198-207. PubMed ID: 12588191
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR.
Subramanian R; Lin CC; Ho JZ; Pitzenberger SM; Silva-Elipe MV; Gibson CR; Braun MP; Yu X; Yergey JL; Singh R
Drug Metab Dispos; 2003 Nov; 31(11):1437-47. PubMed ID: 14570777
[TBL] [Abstract][Full Text] [Related]
3. Comparative biotransformation of pyrazinone-containing corticotropin-releasing factor receptor-1 antagonists: minimizing the reactive metabolite formation.
Zhuo X; Hartz RA; Bronson JJ; Wong H; Ahuja VT; Vrudhula VM; Leet JE; Huang S; Macor JE; Shu YZ
Drug Metab Dispos; 2010 Jan; 38(1):5-15. PubMed ID: 19833844
[TBL] [Abstract][Full Text] [Related]
4. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
5. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
6. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
[TBL] [Abstract][Full Text] [Related]
7. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
[TBL] [Abstract][Full Text] [Related]
8. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
Masubuchi N; Makino C; Murayama N
Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
[TBL] [Abstract][Full Text] [Related]
9. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
[TBL] [Abstract][Full Text] [Related]
10. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
[TBL] [Abstract][Full Text] [Related]
11. Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.
Kalgutkar AS; Henne KR; Lame ME; Vaz AD; Collin C; Soglia JR; Zhao SX; Hop CE
Chem Biol Interact; 2005 Jun; 155(1-2):10-20. PubMed ID: 15978881
[TBL] [Abstract][Full Text] [Related]
12. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
Ruan Q; Zhu M
Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
[TBL] [Abstract][Full Text] [Related]
13. Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.
Xu S; Zhu B; Teffera Y; Pan DE; Caldwell CG; Doss G; Stearns RA; Evans DC; Beconi MG
Drug Metab Dispos; 2005 Jan; 33(1):121-30. PubMed ID: 15486074
[TBL] [Abstract][Full Text] [Related]
14. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
15. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Lim HK; Chen J; Cook K; Sensenhauser C; Silva J; Evans DC
Rapid Commun Mass Spectrom; 2008 Apr; 22(8):1295-311. PubMed ID: 18383206
[TBL] [Abstract][Full Text] [Related]
16. Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Samuel K; Yin W; Stearns RA; Tang YS; Chaudhary AG; Jewell JP; Lanza T; Lin LS; Hagmann WK; Evans DC; Kumar S
J Mass Spectrom; 2003 Feb; 38(2):211-21. PubMed ID: 12577288
[TBL] [Abstract][Full Text] [Related]
17. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
Erve JC; Vashishtha SC; DeMaio W; Talaat RE
Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
[TBL] [Abstract][Full Text] [Related]
18. In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.
Lin CC; Wong BK; Burgey CS; Gibson CR; Singh R
J Pharm Biomed Anal; 2005 Oct; 39(5):1014-20. PubMed ID: 16023819
[TBL] [Abstract][Full Text] [Related]
19. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
Subramanian R; Lee MR; Allen JG; Bourbeau MP; Fotsch C; Hong FT; Tadesse S; Yao G; Yuan CC; Surapaneni S; Skiles GL; Wang X; Wohlhieter GE; Zeng Q; Zhou Y; Zhu X; Li C
Chem Res Toxicol; 2010 Mar; 23(3):653-63. PubMed ID: 20095585
[TBL] [Abstract][Full Text] [Related]
20. Delineating novel metabolic pathways of DPC 963, a non-nucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC/MS and LC/NMR.
Chen H; Shockcor J; Chen W; Espina R; Gan LS; Mutlib AE
Chem Res Toxicol; 2002 Mar; 15(3):388-99. PubMed ID: 11896687
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
