175 related articles for article (PubMed ID: 12590540)
1. Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation.
Brands KM; Payack JF; Rosen JD; Nelson TD; Candelario A; Huffman MA; Zhao MM; Li J; Craig B; Song ZJ; Tschaen DM; Hansen K; Devine PN; Pye PJ; Rossen K; Dormer PG; Reamer RA; Welch CJ; Mathre DJ; Tsou NN; McNamara JM; Reider PJ
J Am Chem Soc; 2003 Feb; 125(8):2129-35. PubMed ID: 12590540
[TBL] [Abstract][Full Text] [Related]
2. Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist.
Hale JJ; Mills SG; MacCoss M; Finke PE; Cascieri MA; Sadowski S; Ber E; Chicchi GG; Kurtz M; Metzger J; Eiermann G; Tsou NN; Tattersall FD; Rupniak NM; Williams AR; Rycroft W; Hargreaves R; MacIntyre DE
J Med Chem; 1998 Nov; 41(23):4607-14. PubMed ID: 9804700
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of a tetrahydropyran NK1 receptor antagonist via asymmetric conjugate addition.
Huffman MA; Smitrovich JH; Rosen JD; Boice GN; Qu C; Nelson TD; McNamara JM
J Org Chem; 2005 May; 70(11):4409-13. PubMed ID: 15903319
[TBL] [Abstract][Full Text] [Related]
4. 2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
Hale JJ; Mills SG; MacCoss M; Shah SK; Qi H; Mathre DJ; Cascieri MA; Sadowski S; Strader CD; MacIntyre DE; Metzger JM
J Med Chem; 1996 Apr; 39(9):1760-2. PubMed ID: 8627597
[No Abstract] [Full Text] [Related]
5. Stereoselective preparation of a cyclopentane-based NK1 receptor antagonist bearing an unsymmetrically substituted sec-sec ether.
Kuethe JT; Marcoux JF; Wong A; Wu J; Hillier MC; Dormer PG; Davies IW; Hughes DL
J Org Chem; 2006 Sep; 71(19):7378-90. PubMed ID: 16958533
[TBL] [Abstract][Full Text] [Related]
6. Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.
Gerspacher M; Lewis C; Ball HA; Howes C; Subramanian N; Ryffel K; Fozard JR
J Med Chem; 2003 Jul; 46(16):3508-13. PubMed ID: 12877589
[TBL] [Abstract][Full Text] [Related]
7. Efficient, stereoselective synthesis of trans-2,5-disubstituted morpholines.
Lanman BA; Myers AG
Org Lett; 2004 Mar; 6(6):1045-7. PubMed ID: 15012096
[TBL] [Abstract][Full Text] [Related]
8. Highly efficient asymmetric synthesis of fluvirucinine A1 via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)-lipase-catalyzed acetylation tandem process.
Liang B; Negishi E
Org Lett; 2008 Jan; 10(2):193-5. PubMed ID: 18076181
[TBL] [Abstract][Full Text] [Related]
9. Fosaprepitant: a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
Navari RM
Expert Rev Anticancer Ther; 2008 Nov; 8(11):1733-42. PubMed ID: 18983233
[TBL] [Abstract][Full Text] [Related]
10. Assessment of the in-vivo stereochemical integrity of aprepitant based on the analysis of human plasma samples via high-performance liquid chromatography with mass spectrometric detection.
Kline WF; Woolf EJ; Matuszewski BK
Biomed Chromatogr; 2005 Sep; 19(7):513-7. PubMed ID: 15828059
[TBL] [Abstract][Full Text] [Related]
11. Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
Jiang J; Bunda JL; Doss GA; Chicchi GG; Kurtz MM; Tsao KL; Tong X; Zheng S; Upthagrove A; Samuel K; Tschirret-Guth R; Kumar S; Wheeldon A; Carlson EJ; Hargreaves R; Burns D; Hamill T; Ryan C; Krause SM; Eng W; DeVita RJ; Mills SG
J Med Chem; 2009 May; 52(9):3039-46. PubMed ID: 19354254
[TBL] [Abstract][Full Text] [Related]
12. Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds.
Sladojevich F; Trabocchi A; Guarna A
Org Biomol Chem; 2008 Sep; 6(18):3328-36. PubMed ID: 18802639
[TBL] [Abstract][Full Text] [Related]
13. Stereoselective synthesis of highly substituted gamma-lactams by the [3+2] annulation of alpha-siloxy allylic silanes with chlorosulfonyl isocyanate.
Romero A; Woerpel KA
Org Lett; 2006 May; 8(10):2127-30. PubMed ID: 16671798
[TBL] [Abstract][Full Text] [Related]
14. Chiral synthesis of (2S,3S)-2-(2-morpholin-2-yl-2-phenylmethoxy)phenol.
Prabhakaran J; Majo VJ; Mann JJ; Kumar JS
Chirality; 2004 Mar; 16(3):168-73. PubMed ID: 14770413
[TBL] [Abstract][Full Text] [Related]
15. The oral NK(1) antagonist, aprepitant, given with standard antiemetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: a combined analysis of two randomised, placebo-controlled phase III clinical trials.
de Wit R; Herrstedt J; Rapoport B; Carides AD; Guoguang-Ma J; Elmer M; Schmidt C; Evans JK; Horgan KJ
Eur J Cancer; 2004 Feb; 40(3):403-10. PubMed ID: 14746859
[TBL] [Abstract][Full Text] [Related]
16. Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist.
Zuev D; Michne JA; Huang H; Beno BR; Wu D; Gao Q; Torrente JR; Xu C; Conway CM; Macor JE; Dubowchik GM
Org Lett; 2005 Jun; 7(12):2465-8. PubMed ID: 15932224
[TBL] [Abstract][Full Text] [Related]
17. Stereoselective synthesis of a novel 2-aza-7-oxabicyclo[3.3.0]octane as neurokinin-1 receptor antagonist.
Shishido Y; Ito F; Morita H; Ikunaka M
Bioorg Med Chem Lett; 2007 Dec; 17(24):6887-90. PubMed ID: 17967540
[TBL] [Abstract][Full Text] [Related]
18. Asymmetric synthesis of (+)-(S,S)-reboxetine via a new (S)-2-(hydroxymethyl)morpholine preparation.
Brenner E; Baldwin RM; Tamagnan G
Org Lett; 2005 Mar; 7(5):937-9. PubMed ID: 15727479
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of (-)-quinocarcin by directed condensation of alpha-amino aldehydes.
Kwon S; Myers AG
J Am Chem Soc; 2005 Dec; 127(48):16796-7. PubMed ID: 16316220
[TBL] [Abstract][Full Text] [Related]
20. Ceric ammonium nitrate-catalyzed azidation of 1,2-anhydro sugars: application in the synthesis of structurally diverse sugar-derived morpholine 1,2,3-triazoles and 1,4-oxazin-2-ones.
Reddy YS; Pal AP; Gupta P; Ansari AA; Vankar YD
J Org Chem; 2011 Aug; 76(15):5972-84. PubMed ID: 21679000
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]