BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 12593654)

  • 1. Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
    Nöteberg D; Hamelink E; Hultén J; Wahlgren M; Vrang L; Samuelsson B; Hallberg A
    J Med Chem; 2003 Feb; 46(5):734-46. PubMed ID: 12593654
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.
    Muthas D; Nöteberg D; Sabnis YA; Hamelink E; Vrang L; Samuelsson B; Karlén A; Hallberg A
    Bioorg Med Chem; 2005 Sep; 13(18):5371-90. PubMed ID: 16054370
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.
    Nöteberg D; Schaal W; Hamelink E; Vrang L; Larhed M
    J Comb Chem; 2003; 5(4):456-64. PubMed ID: 12857114
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
    Ersmark K; Feierberg I; Bjelic S; Hamelink E; Hackett F; Blackman MJ; Hultén J; Samuelsson B; Aqvist J; Hallberg A
    J Med Chem; 2004 Jan; 47(1):110-22. PubMed ID: 14695825
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV.
    Ersmark K; Nervall M; Gutiérrez-de-Terán H; Hamelink E; Janka LK; Clemente JC; Dunn BM; Gogoll A; Samuelsson B; Qvist J; Hallberg A
    Bioorg Med Chem; 2006 Apr; 14(7):2197-208. PubMed ID: 16307884
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.
    Gupta D; Yedidi RS; Varghese S; Kovari LC; Woster PM
    J Med Chem; 2010 May; 53(10):4234-47. PubMed ID: 20438064
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.
    Romeo S; Dell'Agli M; Parapini S; Rizzi L; Galli G; Mondani M; Sparatore A; Taramelli D; Bosisio E
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2931-4. PubMed ID: 15125962
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
    Hidaka K; Kimura T; Tsuchiya Y; Kamiya M; Ruben AJ; Freire E; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3048-52. PubMed ID: 17400453
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum.
    Gutiérrez-de-Terán H; Nervall M; Ersmark K; Liu P; Janka LK; Dunn B; Hallberg A; Aqvist J
    Biochemistry; 2006 Sep; 45(35):10529-41. PubMed ID: 16939205
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
    Johansson PO; Chen Y; Belfrage AK; Blackman MJ; Kvarnström I; Jansson K; Vrang L; Hamelink E; Hallberg A; Rosenquist A; Samuelsson B
    J Med Chem; 2004 Jun; 47(13):3353-66. PubMed ID: 15189032
    [TBL] [Abstract][Full Text] [Related]  

  • 11. alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
    Orrling KM; Marzahn MR; Gutiérrez-de-Terán H; Aqvist J; Dunn BM; Larhed M
    Bioorg Med Chem; 2009 Aug; 17(16):5933-49. PubMed ID: 19635672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases.
    Abdel-Rahman HM; Kimura T; Hidaka K; Kiso A; Nezami A; Freire E; Hayashi Y; Kiso Y
    Biol Chem; 2004 Nov; 385(11):1035-9. PubMed ID: 15576323
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.
    Zogota R; Kinena L; Withers-Martinez C; Blackman MJ; Bobrovs R; Pantelejevs T; Kanepe-Lapsa I; Ozola V; Jaudzems K; Suna E; Jirgensons A
    Eur J Med Chem; 2019 Feb; 163():344-352. PubMed ID: 30529637
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid.
    Kasam V; Zimmermann M; Maass A; Schwichtenberg H; Wolf A; Jacq N; Breton V; Hofmann-Apitius M
    J Chem Inf Model; 2007; 47(5):1818-28. PubMed ID: 17727268
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.
    Kiso A; Hidaka K; Kimura T; Hayashi Y; Nezami A; Freire E; Kiso Y
    J Pept Sci; 2004 Nov; 10(11):641-7. PubMed ID: 15568678
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exploring the flap pocket of the antimalarial target plasmepsin II: the "55 % rule" applied to enzymes.
    Zürcher M; Gottschalk T; Meyer S; Bur D; Diederich F
    ChemMedChem; 2008 Feb; 3(2):237-40. PubMed ID: 17918177
    [No Abstract]   [Full Text] [Related]  

  • 17. New inhibitors of the malaria aspartyl proteases plasmepsin I and II.
    Dahlgren A; Kvarnström I; Vrang L; Hamelink E; Hallberg A; Rosenquist A; Samuelsson B
    Bioorg Med Chem; 2003 Aug; 11(16):3423-37. PubMed ID: 12878137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of acridinyl hydrazides as potent aspartic protease inhibitors.
    Azim MK; Ahmed W; Khan IA; Rao NA; Khan KM
    Bioorg Med Chem Lett; 2008 May; 18(9):3011-5. PubMed ID: 18417344
    [TBL] [Abstract][Full Text] [Related]  

  • 19. High antiplasmodial activity of novel plasmepsins I and II inhibitors.
    Dell'Agli M; Parapini S; Galli G; Vaiana N; Taramelli D; Sparatore A; Liu P; Dunn BM; Bosisio E; Romeo S
    J Med Chem; 2006 Dec; 49(25):7440-9. PubMed ID: 17149873
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
    Hidaka K; Kimura T; Ruben AJ; Uemura T; Kamiya M; Kiso A; Okamoto T; Tsuchiya Y; Hayashi Y; Freire E; Kiso Y
    Bioorg Med Chem; 2008 Dec; 16(23):10049-60. PubMed ID: 18952439
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.