244 related articles for article (PubMed ID: 12598647)
1. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis.
Cheng YQ; Tang GL; Shen B
Proc Natl Acad Sci U S A; 2003 Mar; 100(6):3149-54. PubMed ID: 12598647
[TBL] [Abstract][Full Text] [Related]
2. Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.
Tang GL; Cheng YQ; Shen B
Chem Biol; 2004 Jan; 11(1):33-45. PubMed ID: 15112993
[TBL] [Abstract][Full Text] [Related]
3. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.
Tang GL; Cheng YQ; Shen B
J Nat Prod; 2006 Mar; 69(3):387-93. PubMed ID: 16562841
[TBL] [Abstract][Full Text] [Related]
4. Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
Cheng YQ; Tang GL; Shen B
J Bacteriol; 2002 Dec; 184(24):7013-24. PubMed ID: 12446651
[TBL] [Abstract][Full Text] [Related]
5. C-S bond cleavage by a polyketide synthase domain.
Ma M; Lohman JR; Liu T; Shen B
Proc Natl Acad Sci U S A; 2015 Aug; 112(33):10359-64. PubMed ID: 26240335
[TBL] [Abstract][Full Text] [Related]
6. Type I polyketide synthases that require discrete acyltransferases.
Cheng YQ; Coughlin JM; Lim SK; Shen B
Methods Enzymol; 2009; 459():165-86. PubMed ID: 19362640
[TBL] [Abstract][Full Text] [Related]
7. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
Du L; Sánchez C; Chen M; Edwards DJ; Shen B
Chem Biol; 2000 Aug; 7(8):623-42. PubMed ID: 11048953
[TBL] [Abstract][Full Text] [Related]
8. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
Seo JW; Ma M; Kwong T; Ju J; Lim SK; Jiang H; Lohman JR; Yang C; Cleveland J; Zazopoulos E; Farnet CM; Shen B
Biochemistry; 2014 Dec; 53(49):7854-65. PubMed ID: 25405956
[TBL] [Abstract][Full Text] [Related]
9. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis.
Huang Y; Tang GL; Pan G; Chang CY; Shen B
Org Lett; 2016 Sep; 18(17):4288-91. PubMed ID: 27541042
[TBL] [Abstract][Full Text] [Related]
10. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.
Kwong T; Ma M; Pan G; Hindra ; Yang D; Yang C; Lohman JR; Rudolf JD; Cleveland JL; Shen B
Biochemistry; 2018 Aug; 57(33):5005-5013. PubMed ID: 30070831
[TBL] [Abstract][Full Text] [Related]
11. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
Wu K; Chung L; Revill WP; Katz L; Reeves CD
Gene; 2000 Jun; 251(1):81-90. PubMed ID: 10863099
[TBL] [Abstract][Full Text] [Related]
12. Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.
Piel J; Hertweck C; Shipley PR; Hunt DM; Newman MS; Moore BS
Chem Biol; 2000 Dec; 7(12):943-55. PubMed ID: 11137817
[TBL] [Abstract][Full Text] [Related]
13. Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei.
Tang L; Yoon YJ; Choi CY; Hutchinson CR
Gene; 1998 Aug; 216(2):255-65. PubMed ID: 9729415
[TBL] [Abstract][Full Text] [Related]
14. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
Tang GL; Cheng YQ; Shen B
J Biol Chem; 2007 Jul; 282(28):20273-82. PubMed ID: 17502372
[TBL] [Abstract][Full Text] [Related]
15. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity.
Florova G; Kazanina G; Reynolds KA
Biochemistry; 2002 Aug; 41(33):10462-71. PubMed ID: 12173933
[TBL] [Abstract][Full Text] [Related]
16. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
Hans M; Hornung A; Dziarnowski A; Cane DE; Khosla C
J Am Chem Soc; 2003 May; 125(18):5366-74. PubMed ID: 12720450
[TBL] [Abstract][Full Text] [Related]
17. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.
Huang Y; Yang D; Pan G; Tang GL; Shen B
Appl Microbiol Biotechnol; 2016 Dec; 100(24):10555-10562. PubMed ID: 27704182
[TBL] [Abstract][Full Text] [Related]
18. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
Lau J; Fu H; Cane DE; Khosla C
Biochemistry; 1999 Feb; 38(5):1643-51. PubMed ID: 9931032
[TBL] [Abstract][Full Text] [Related]
19. Mechanisms of molecular recognition in the pikromycin polyketide synthase.
Chen S; Xue Y; Sherman DH; Reynolds KA
Chem Biol; 2000 Dec; 7(12):907-18. PubMed ID: 11137814
[TBL] [Abstract][Full Text] [Related]
20. Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis.
Zhou P; Florova G; Reynolds KA
Chem Biol; 1999 Aug; 6(8):577-84. PubMed ID: 10421763
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
